Clinical significance of the determination of matrix metalloproteinases in newborns with congenital herpes virus infection
https://doi.org/10.21508/1027-4065-2016-61-1-46-50
Abstract
The time course of changes in the serum levels of matrix metalloproteinases (MMP-8, MMP-9) was studied in neonatal infants after perinatal exposure to herpes simplex virus in the early neonatal period to elaborate criteria for the early preclinical diagnosis of its infection and to define the severity of the pathological process. Fifty-seven infants born to mothers with chronic herpes virus infection were examined. MMP-8 and MMP-9 were determined by a solid-phase enzyme immunoassay using specific reagents (R&D Diagnostics Inc., USA). Different changes were found in MMP-8 and MMP-9 levels in relation to the onset of clinical symptoms of congenital herpes virus infection. The elevated plasma metalloproteinase levels in the first 24 hours after birth in newborn infants at risk for herpes virus infection may be regarded as preclinical markers for the manifestations of congenital infection. The magnitude of changes in serum metalloproteinase levels correlates with the severity of the disease.
About the Authors
S. N. Beniova
Far Eastern Federal University
Russian Federation
Russian Federation
S. Yu. Figol
Primorye Territory Perinatal Center
Russian Federation
Russian Federation
E. V. Markelova
Pacific State Medical University, Vladivostok
Russian Federation
Russian Federation
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Review
For citations:
Beniova S.N., Figol S.Yu., Markelova E.V. Clinical significance of the determination of matrix metalloproteinases in newborns with congenital herpes virus infection. Rossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics). 2016;61(1):46-50. (In Russ.) https://doi.org/10.21508/1027-4065-2016-61-1-46-50
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