Buy (150 RUB)
Generate QR code
Open Access
Subscription or Fee Access
“Masks” of fever of unknown origin in children
https://doi.org/10.21508/1027-4065-2024-69-1-66-73
Abstract
The article presents an analysis of cases of hospitalized children with fever of unknown origin. Purpose: to study the nosological structure of the causes of fever of unknown genesis in hospitalized children.
Material and methods: a retrospective analysis of the medical histories of children hospitalized in the pediatric department was carried out for 2022–2023. All children underwent a comprehensive laboratory and instrumental examination.
Results: the largest proportion (43,9 %) were school-age children who, in addition to fever, had complaints of weakness (87,8 %) and decreased appetite (85,4 %). Anemia (51,2 %), acceleration of ESR (47,6 %) and an increase in C-reactive protein (45,1 %) were most often recorded in the analyses. The causes of fever of unknown origin in 65,9 % of children were infectious diseases, in 19,5 % — autonomic dysfunction syndrome with a violation of thermoregulation, in 6,1 % — systemic connective tissue diseases, in 4,9 % — oncological pathology, in 2,4 % — inflammatory diseases of the gastrointestinal tract.
The results of the study can be applied in pediatric practice, monitoring of children with infectious pathology.
About the Authors
R. M. Fayzullina
Bashkir State Medical University
Russian Federation
Russian Federation
Ufa
N. V. Samigullina
Bashkir State Medical University; Clinical Emergency Hospital
Russian Federation
Russian Federation
Ufa
V. V. Victorov
Bashkir State Medical University
Russian Federation
Russian Federation
Ufa
References
1. Dovnar-Zapol’skaya O.N. Fever of unknown origin in children: etiology, choice of optimal antipyretic therapy. Pediatrija. Vostochnaja Evropa 2018; 6(3): 496–501. (in Russ.)
2. Tatochenko V.K., Bakradze M.D. Fever of unknown etiology in children. Infekcionnye bolezni 2008; 6(2): 78–81. (in Russ.)
3. Antoon J.W., Peritz D.C., Parsons M.R., Skinner A.C., Lohr J.A. Etiology and Resource Use of Fever of Unknown Origin in Hospitalized Children. Hosp Pediatr 2018; 8 (3): 135–140. DOI: 10.1542/hpeds.2017–0098
4. Tolan R.W. Fever of unknown origin: a diagnostic approach to this vexing problem. Clin Pediatr (Phila) 2010; 49 (3): 207–213. DOI: 10.1177/0009922809347799
5. Pikuza O.I., Sulejmanova Z.Ya., Zakirova A.M., Pikuza A.V., Rashitov L.F. Fever syndrome of unknown origin in pediatric practice. Sovremennye problemy nauki i obrazovanija 2018; 6: 90 (in Russ.)
6. Michael G.C. Fever of Unknown Origin in Childhood. Pediatr Clin North Am 2017; 64 (1): 205–230. DOI: 10.1016/j.pcl.2016.08.014
7. Il’muhina L.V., Galyavin A.V., Sveshnikova M.A. Fever of unknown origin in the clinic of infectious diseases. Ul’janovskij mediko-biologicheskij zhurnal 2013; 3: 34–39. (in Russ.)
8. Cunha A.B., Hage J.E., Nouri Y. Recurrent fever of unknown origin (FUO): aseptic meningitis, hepatosplenomegaly, pericarditis and a double quotidian fever due to juvenile rheumatoid arthritis (JRA). Heart Lung 2012; 41 (2): 177–80. DOI: 10.1016/j.hrtlng.2011.01.002
9. Rajeshwar D., Dipti A. Fever in Children and Fever of Unknown Origin. Indian J Pediatr 2016; 83 (1): 38–43. DOI: 10.1007/s12098–015–1724–4
10. Rigante D., Esposito S. A roadmap for fever of unknown origin in children. Int J Immunopathol Pharmacol 2013; 26 (2): 315–26. DOI: 10.1177/039463201302600205
11. Bliznyakova D.S., Grigorchuk V.A. Management tactics for children with fever of unknown origin in outpatient settings. Forcipe 2021; 4(S1): 344 (in Russ.)
12. Dvoreckij L.I. Fever of unknown origin: is the decoding real? Medical Medicinskij vestnik Severnogo Kavkaza 2018; 13(2): 422–425. (in Russ.)
13. Muhin N.A. Fever of unknown origin. Pharmateca 2011; 19(232): 9–14 (in Russ.)
14. Meshkova O.I., Mel’nikov V.L., Gerbel’ M.N. Fever of unknown origin in children in the practice of an infectious disease specialist. Vestnik Penzenskogo Gosudarstvennogo universiteta 2020; 1(29): 90–95 (in Russ.)
15. Fusco F.M., Pisapia R., Nardiello S., Cicala S.D., Gaeta G.B., Brancaccio G. Fever of unknown origin (FUO): which are the factors influencing the final diagnosis? A 2005–2015 systematic review. BMC Infect Dis 2019; 19 (1): 653. DOI: 10.1186/s12879–019–4285–8
16. Mukovozova L.A., Tokareva A.Z., Aliev B.A., Levashova L.G., Sibiryakov A.K., Sutormina A.V., Bajtuleuova N.Zh. Fever of unknown origin. Nauka i zdravoohranenie 2013; 3: 27–28. (in Russ.)
17. Dhodapkar R., Mugunthan M., Thangaveli K., Sivaraji M., Veerappan K., Gunalan A. Epstein-Barr Virus: An Infrequent Pathogen of Acute Undifferentiated Febrile Illness From a Tertiary Care Hospital in Southern India. Cureus 2021; 13 (9): 18207. DOI: 10.7759/cureus.18207
18. Chien Y.L., Huang F. L., Huang Ch. M., Chen P. Y. Clinical approach to fever of unknown origin in children. J Microbiol Immunol Infect 2017; 50 (6): 893–898. DOI: 10.1016/j.jmii.2015.08.007
19. Bing H., Tian-Ming Ch., Shu-Ping L., Hui-Li H., Ling-Yun G., He-Ying Ch., Shao-Ying L., Gang L. Fever of unknown origin (FUO) in children: a single-centre experience from Beijing, China. BMJ Open 2022; 12(3): 049840. DOI: 10.1136/bmjopen-2021–049840
20. Cho Ch.Yi. , Chou-Cheng Li, Lee M.L., Hsu Ch.L. Chen Ch.J., Chang L.Y., Lo Ch.W., Chiang Sh.F., Wu K.G. Clinical analysis of fever of unknown origin in children: A 10-year experience in a northern Taiwan medical center. J Microbiol Immunol Infect 2017; 50 (1): 40–45. DOI: 10.1016/j.jmii.2015.01.001
Review
For citations:
Fayzullina R.M., Samigullina N.V., Victorov V.V. “Masks” of fever of unknown origin in children. Rossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics). 2024;69(1):66-73. (In Russ.) https://doi.org/10.21508/1027-4065-2024-69-1-66-73
Views:
772
Email this article 