Buy (150 RUB)
Generate QR code
Open Access
Subscription or Fee Access
Insect anaphylaxis
https://doi.org/10.21508/1027-4065-2024-69-4-102-108
Abstract
Anaphylaxis is a serious allergic reaction that is life-threatening. Insect anaphylaxis is diagnosed in one in 10 patients with anaphylaxis. Timely treatment and a clear algorithm of tactics to manage the condition can save the patient’s life. Diagnostics and properly selected recommendations will bring more understanding of the principles of exclusion of future reactions. This article presents data on the prevalence, clinical manifestations, diagnosis and treatment of patients with insect anaphylaxis. A clinical case of wasp sting anaphylaxis is also presented.
Supporting agencies: The research was supported by a grant from the Government of Moscow No. 0408–1. The authors of this article confirmed the lack of conflict of interest and financial support, which should be reported
About the Authors
A. N. Pampura
Veltischev Research and Clinical Institute for Pediatrics and Pediatric Surgery of the Pirogov Russian National Research Medical University Research Clinical Institute of Pediatrics; Russian Medical Academy of Continuous Professional Education
Russian Federation
Russian Federation
Moscow
N. V. Esakova
Veltischev Research and Clinical Institute for Pediatrics and Pediatric Surgery of the Pirogov Russian National Research Medical University Research Clinical Institute of Pediatrics
Russian Federation
Russian Federation
Moscow
E. F. Zhukalina
Veltischev Research and Clinical Institute for Pediatrics and Pediatric Surgery of the Pirogov Russian National Research Medical University Research Clinical Institute of Pediatrics
Russian Federation
Russian Federation
Moscow
E. A. Filippova
Veltischev Research and Clinical Institute for Pediatrics and Pediatric Surgery of the Pirogov Russian National Research Medical University Research Clinical Institute of Pediatrics
Russian Federation
Russian Federation
Moscow
References
1. Tankersley M.S., Ledford D.K. Stinging insect allergy: state of the art 2015. J Allergy Clin Immunol Pract 2015; 3(3): 315–322. DOI: 10.1016/j.jaip.2015.03.012
2. Worm M., Moneret-Vautrin A., Scherer K., Lang R., Fernandez-Rivas M., Cardona V. et al. First European data from the network of severe allergic reaction (NORA). Allergy 2014; 69: 1397–1404. DOI: 10.1111/all.12475
3. Bilò M.B., Pravettoni V., Bignardi D., Bonadonna P., Mauro M., Novembre E. et al. Hymenoptera Venom Allergy: Management of Children and Adults in Clinical Practice. J Investig Allergol Clin Immunol 2019; 29(3): 180–205. DOI: 10.18176/jiaci.0310
4. Graif Y., Romano-Zelekha O., Livne I., Green M.S., Shohat T. Increased rate and greater severity of allergic reactions to insect sting among schoolchildren with atopic diseases. Pediatr Allergy Immunol 2009; 20: 757–762. DOI: 10.1111/j.1399–3038.2009.00863.x
5. Golden D.B., Kagey-Sobotka A., Norman P.S., Hamilton R.G., Lichtenstein L.M. Outcomes of allergy to insect stings in children, with and without venom immunotherapy. N Engl J Med 2004; 351: 668–764. DOI: 10.1056/NEJMoa022952
6. Abrams E.M., Golden D.B.K. Approach to Patients with Stinging Insect Allergy. Med Clin North Am 2020; 104(1): 129–143. DOI: 10.1016/j.mcna.2019.08.006
7. Bilò M.B., Bonifazi F. The natural history and epidemiology of insect venom allergy: clinical implications. Clin Exp Allergy 2009; 39:1467–1476. DOI: 10.1111/j.1365–2222.2009.03324.x
8. Pumphrey R.S. Fatal anaphylaxis in the UK, 1992–2001. Novartis Found Symp 2004; 257: 116–128.
9. Golden D.B., Demain J., Freeman T., Graft D., Tankersley M., Tracy J. et al. Stinging insect hypersensitivity: A practice parameter update 2016. Ann Allergy Asthma Immunol 2017; 118(1): 28–54. DOI: 10.1016/j.anai.2016.10.031
10. Hoffman D.R., Jacobson R.S. Allergens in Hymenoptera venom. XII. How much protein is in a sting? Ann Allergy 1984; 52: 276–278.
11. Lockey R.F., Turkeltaub P.C., Baird-Warren I.A., Olive C.A., Olive E.S., Peppe B.C. et al. The Hymenoptera venom study I, 1979–1982: demographics and history-sting data. J Allergy Clin Immunol 1988; 82(3 Pt 1): 370–381. DOI: 10.1016/0091–6749(88)90008–5
12. Stoevesandt J., Hain J., Kerstan A., Trautmann A. Over- and underestimated parameters in severe Hymenoptera venom-induced anaphylaxis: cardiovascular medication and absence of urticaria/angioedema. J Allergy Clin Immunol 2012; 130(3): 698–704.e1. DOI: 10.1016/j.jaci.2012.03.024
13. Pucci S., Antonicelli L., Bilò M.B., Garritani M.S., Bonifazi F. Shortness of interval between two stings as risk factor for developing Hymenoptera venom allergy. Allergy 1994; 49(10): 894–896. DOI: 10.1111/j.1398–9995.1994.tb00796.x
14. Ilyina N.I., Zabolotskikh I.B., Astafieva N.G., Bayalieva A.Zh., Kulikov A.V., Latysheva T.V. et al. Anaphylactic shock (2<sup>nd</sup> revision). Clinical guidelines of Russian Association of Allergists and Clinical Immunologists and the All-Russian Public Organization “Federation of Anesthesiologists and Reanimatologists”. Vestnik intensivnoi terapii imeni A.I. Saltanova 2024; 2: 7–20. (Im Russ.) DOI: 10.21320/1818–474X-2024–2–7–20
15. Hamilton R.G., Williams P.B. Specific IgE Testing Task Force of the American Academy of Allergy, Asthma & Immunology; American College of Allergy, Asthma and Immunology. Human IgE antibody serology: a primer for the practicing North American allergist/immunologist. J Allergy Clin Immunol 2010; 126(1): 33–38. DOI: 10.1016/j.jaci.2010.03.014
16. Biló B.M., Rueff F., Mosbech H., Bonifazi F., Oude-Elberink J.N.G., the EAACI Interest Group on Insect Venom Hypersensitivity. Diagnosis of Hymenoptera venom allergy. Allergy 2005; 60(11): 1339–1349. DOI: 10.1111/j.1398–9995.2005.00963.x
17. Blank S., Haemmerle S., Jaeger T., Russkamp D., Ring J., Carsten B. et al. Prevalence of Hymenoptera venom allergy and sensitisation in the population-representative German KORA cohort. Allergo J Int 2019; 28(6): 183–191. DOI: 10.1007/s40629–018–0089–4
18. Arzt L., Bokanovic D., Schrautzer C., Laipold K., Möbs C., Pfützner W. et al. Immunological differences between insect venom-allergic patients with and without immunotherapy and asymptomatically sensitized subjects. Allergy 2018; 73(6): 1223–1231. DOI: 10.1111/all.13368
19. Ruiz B., Serrano P., Moreno C. IgE-Api m 4 Is Useful for Identifying a Particular Phenotype of Bee Venom Allergy. J Investig Allergol Clin Immunol 2016; 26(6): 355–361. DOI: 10.18176/jiaci.0053
20. Frick M., Fischer J., Helbling A., Ruëff F., Wieczorek D., Ollert M. et al. Predominant Api m 10 sensitization as risk factor for treatment failure in honey bee venom immunotherapy. J Allergy Clin Immunol 2016; 138(6): 1663–1671.e9. DOI: 10.1016/j.jaci.2016.04.024
21. Gattinger P., Lupinek C., Kalogiros L., Silar M., Zidarn M., Korosec P. et al. The culprit insect but not severity of allergic reactions to bee and wasp venom can be determined by molecular diagnosis. PLoS One 2018; 13(6): e0199250. DOI: 10.1371/journal.pone.0199250
22. Vos B.J.P.R., van Anrooij B., van Doormaal J.J., Dubois A.E.J., Oude Elberink J.N.G. Fatal Anaphylaxis to Yellow Jacket Stings in Mastocytosis: Options for Identification and Treatment of At-Risk Patients. J Allergy Clin Immunol Pract 2017; 5(5): 1264–1271. DOI: 10.1016/j.jaip.2017.03.019
23. Dramburg S., Hilger C., Santos A.F., de Las Vecillas L., Aalberse R.C., Acevedo N. et al. EAACI Molecular Allergology User’s Guide 2.0. Pediatr Allergy Immunol 2023; 34 Suppl 28: e13854. DOI: 10.1111/pai.13854
24. Schiener M., Eberlein B., Moreno-Aguilar C., Pietsch G., Serrano P., McIntyre M. et al. Application of recombinant antigen 5 allergens from seven allergy-relevant Hymenoptera species in diagnostics. Allergy 2017; 72(1): 98–108. DOI: 10.1111/all.13000
25. van der Linden P.W., Hack C.E., Poortman J., Vivié-Kipp Y.C., Struyvenberg A., van der Zwan J.K. Insect-sting challenge in 138 patients: relation between clinical severity of anaphylaxis and mast cell activation. J Allergy Clin Immunol 1992; 90(1): 110–118. DOI: 10.1016/s0091–6749(06)80017–5
26. Vadas P., Gold M., Perelman B., Liss G.M., Lack G., Blyth T. et al. Platelet-activating factor, PAF acetylhydrolase, and severe anaphylaxis. N Engl J Med. 2008;358(1):28–35. DOI: 10.1056/NEJMoa070030.
27. Ruëff F., Przybilla B., Biló M.B., Müller U., Scheipl F., Aberer W. et al. Predictors of severe systemic anaphylactic reactions in patients with Hymenoptera venom allergy: importance of baseline serum tryptase-a study of the European Academy of Allergology and Clinical Immunology Interest Group on Insect Venom Hypersensitivity. J Allergy Clin Immunol 2009; 124(5): 1047–54. DOI: 10.1016/j.jaci.2009.08.027
Review
For citations:
Pampura A.N., Esakova N.V., Zhukalina E.F., Filippova E.A. Insect anaphylaxis. Rossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics). 2024;69(4):102-108. (In Russ.) https://doi.org/10.21508/1027-4065-2024-69-4-102-108
Views:
361
Email this article 