

Overlap syndrome in Crohn’s disease
https://doi.org/10.21508/1027-4065-2024-69-5-115-118
Abstract
The diagnosis of inflammatory bowel diseases (IBD) in children can be challenging for pediatricians. Extra-intestinal manifestations, such as hepatobiliary pathology, often complicate the diagnosis of these conditions. Hepatobiliary pathology is often an extraintestinal manifestation of inflammatory bowel disease. Patients with combined liver pathology (autoimmune hepatitis and primary sclerosing cholangitis) and inflammatory bowel disease have a higher risk of resistance to treatment, the need for liver transplantation, and a worse prognosis for liver cirrhosis compared to those with isolated liver disease. The article presents a clinical case of the development of overlap syndrome (a combination of autoimmune hepatitis and primary sclerosing cholangitis) in Crohn’s disease in a 7-year-old patient.
About the Authors
D. I. SadykovaRussian Federation
Kazan
Z. R. Khabibrakhmanova
Russian Federation
Kazan
A. A. Kamalova
Russian Federation
Kazan
R. R. Shakirova
Russian Federation
Kazan
A. I. Sadrieva
Russian Federation
Kazan
References
1. Chang Sh., Shen B. Chapter 2 — Classification and Reclassification of Inflammatory Bowel Diseases. From Clinical Perspective, Interventional Inflammatory Bowel Disease: Endoscopic Management and Treatment of Complications. Academic Press, 2018: 17–34. ISBN 9780128113882. DOI: 10.1016/B978–0–12–811388–2.00002–6
2. Kucharska M., Daniluk U., Kwiatek-Średzińska K.A., Wasilewska N., Filimoniuk A., Jakimiec P. et al. Hepatobiliary manifestations of inflammatory bowel disease in children. Clin Exper Hepatol 2019; 5(3): 203–209. DOI: 10.5114/ceh.2019.87632
3. Kamalova A.A., Gajfutdinova A.R., Malov A.A., Safina E.R., Nizamova R.A., Basanova L.I. Primary schlerosing cholangitis in children with inflammatory bowel disease. Ros vestn perinatol i pediatr 2021; 66:(5): 150–156. (in Russ.) DOI: 10.21508/1027–4065–2021–66–5–150–156
4. Adike A., Carey E.J., Lindor K. Primary sclerosing cholangitis in children versus adults: lessons for the clinic. Expert Rev Gastroenterol Hepatol 2018; 12(10): 1025–1032. DOI: 10.1080/17474124.2018.1521719
5. Usol’ceva O.V., Surkov A.N., Movsisjan G.B., Potapov A.S., Kulebina E.A., Kulikov K.A., Chernikov V.V. The relationship of inflammatory bowel diseases with the severity of liver damage in autoimmune hepatobiliary pathology: a cross-sectional study. Voprosy sovremennoi pediatrii 2022; 21(2) :105–112. (in Russ.) DOI: 10.15690/pf.v19i2.2407
6. Rajhel’son K.L., Pazenko E.V., Marchenko N.V. Primary sclerosing cholangitis: review of recommendations for diagnosis and treatment of the disease. Consilium Medicum 2017; 19(8): 121–130. (in Russ.) DOI: 10.26442/2075–1753_19.8.121–130
7. Navaneethan U., Parasa S., Venkatesh P.G. Impact of inflammatory bowel disease on postcholecystectomy complications and hospitalization costs: a Nationwide Inpatient Sample study. J Crohns Colitis 2013; 7(5): 164–170. DOI: 10.1016/j.crohns.2012.07.032
8. Ngu J.H., Gearry R.B., Wright A.J. Stedman C.A. Inflammatory bowel disease is associated with poor outcomes of patients with primary sclerosing cholangitis. Clin Gastroenterol Hepatol 2011; 9(12): 1092–1097. DOI: 10.1016/j.cgh.2011.08.027
9. Praskurnichij E.A., Teunova M.H., Balashova O.A., Kulichenko S.V. Cross syndromes in autoimmune liver diseases. Review of literature data and description of a clinical case. Kremlevskaya meditsina. Klinicheskii vestnik 2021; 4: 97–102. (in Russ.)
10. Guifarro D.A., De Oliveira-Gomes D., Beas R., Yibirin-Wakim M.J., Montalvan-Sanchez E.E. Primary Sclerosing Cholangitis-Autoimmune Hepatitis Overlap Syndrome: Significant Barriers in Liver Disease Diagnosis and Treatment Experienced by the Latino Community. Cureus 2023; 15(3): e36126. DOI: 10.7759/cureus.36126
11. Clinical guidelines “Autoimmune hepatitis in children”, the Union of Pediatricians of Russia, 2016; 6. (in Russ.) https://www.pediatr-russia.ru/information/klin-rek/deystvuyushchie-klinicheskie-rekomendatsii/%D0%90%D0%98%D0%93%20%D0%B4%D0%B5%D1%82%D0%B8%20%D0%A1%D0%9F%D0%A0.v1.pdf / Ссылка активна на 13.09.2024.
Review
For citations:
Sadykova D.I., Khabibrakhmanova Z.R., Kamalova A.A., Shakirova R.R., Sadrieva A.I. Overlap syndrome in Crohn’s disease. Rossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics). 2024;69(5):115-118. (In Russ.) https://doi.org/10.21508/1027-4065-2024-69-5-115-118