Pro- and anti-inflammatory mediators in neonates with perinatal pathology
Abstract
Objective: to determine the levels pro- and anti-inflammatory mediators in children with perinatal pathology over time during an early adaptation period. The results of examination were analyzed in 53 newborn infants with perinatal pathology, including 18 babies with intrauterine infection, 20 with perinatal central nervous system (CNS) lesion, and 15 with birth asphyxia and no infectious or neurological diseases. A control group consisted of 30 healthy newborn infants with the physiological course of the early adaptation period. Enzyme immunoassay was used to determine the umbilical cord and peripheral blood levels of intercellular communication mediators (pro- and anti-inflammatory cytokines, acute-phase proteins) on 5—7 days of life. The reduction in interleuMn (IL)-ip, tumor necrosis factor-a (TNF-a), and IL-10 levels, which was associated with the elevated umbilical cord blood concentrations of interferon-Y (IFN-y) and IL-6, was ascertained to be a result of neonatal hypoxic changes. The distinctive characteristic of the cytokine profile in the infants with intrauterine infection is the detection of birth hypercytokinemia (IL-6 and IL-8 levels of more than 70 pg/ml) in conjunction with the high acute-phase protein concentration that is retained during the early adaptation period. The specific features of development of an immune response in the newborn infants with perinatal CNS injury are significant increases in the level of IL-8 within the first week of life and in the concentration of C-reactive protein on 5—7 days of life.
About the Authors
G. N. Chistyakova
Ural Research Institute of Maternity and Infancy Care, Yekaterinburg
Russian Federation
Russian Federation
L. L. Remizova
Ural Research Institute of Maternity and Infancy Care, Yekaterinburg
Russian Federation
Russian Federation
L. A. Gazieva
Ural Research Institute of Maternity and Infancy Care, Yekaterinburg
Russian Federation
Russian Federation
S. V. Bychkova
Ural Research Institute of Maternity and Infancy Care, Yekaterinburg
Russian Federation
Russian Federation
E. V. Zanina
Ural Research Institute of Maternity and Infancy Care, Yekaterinburg
Russian Federation
Russian Federation
B. T. Charipova
Ural Research Institute of Maternity and Infancy Care, Yekaterinburg
Russian Federation
Russian Federation
References
1. Симбирцев А.С. Цитокины: классификация и биологические функции. Цитокины и воспаление 2004; 3: 2: 16— 23. (Simbircev A.S. Cytokines: classification and biological functions. Tsitokiny i vospalenie 2004; 3:2: 16—23.)
2. Кан Н.Е. Современная диагностика внутриутробной инфекции. Пробл репрод 2004; 5: 42—46. (KanN.E. Modern diagnostics of intrauterine infection. Problemy reproduktsii 2004; 5: 42-46.)
3. Эстрин В.В., Ефанова Е.А., Пухтинская М.Г. Способ ранней диагностики сепсиса у новорожденных. Патент на изобретение RU №2180119, 27.02.2002. (Jestrin V.V., Efanova E.A., Puhtinskaja M.G. Method for early diagnosis of sepsis in newborns. Patent for invention № 2180119 RU, 27.02.2002.)
4. Моллаева И.О., Насруллаева Г.М., Гулиев Н.Д. Изучение цитокинового статуса у новорожденных и детей грудного возраста с внутриутробными инфекциями. Медицинские новости 2011; 2: 98—100. (MollaevaN.O., Nasrullaeva G.M., Guliev N.D. Studying the cytokine status in newborns and infants with pre-natal infections. Meditsinskie novosti 2011; 2: 98-100.)
5. Железникова Г.Ф. Цитокины как предикторы течения и исхода инфекций. Цитокины и воспаление 2009; 8: 1: 10—17. (Zheleznikova G.F. Cytokines as predictors of the flow and outcome of the infection. TSitokiny i vospalenie 2009; 8:1: 10-17.)
6. Рогалева Т.Е., ТерешковП.П., Федосеева ТА., Макарова НА. Роль цитокинов в развитии церебральных поражений у новорожденных от матерей с гестозами. Забайкальский медицинский вестник 2007; 2: 21—25. (Rogaleva Т.Е., Tereshkov P.P., FedoseevaTA., MakarovaNA. The role of cytokines in the
7. development of cerebral damage in newborn infants of mothers with the hestosis. Zabajkal'skij meditsinskij vestnik 2007; 2: 21— 25.)
8. Александрова Ю.Н. Роль системы цитокинов в патологии перинатального периода. Педиатрия 2007; 86: 1: 116—118. (Aleksandrova Ju.N. The role system of cytokines in the pathologies of the perinatal period. Pediatriya 2007; 86: 1:116-118.)
9. Беликова М.Э., Сотникова Н.Ю., Чаша Т.В. и др. Иммунологические проблемы у новорожденных с перинатальными поражениями центральной нервной системы. Иваново: ОАО Изд-во «Иваново» 2010; 240. (Belikova MJe., SotnikovaNJu., ChashaTV. et al. Immunological problems in infants with perinatal diseases of the central nervous system. Ivanovo: ОАО Izd-vo "Ivanovo" 2010; 240.)
10. Громада Н.Е. Изменения уровня цитокинов и показателей кариометрии у новорожденных с перинатальной гипоксией. Рос иммунолжурн 2008; 3: 87—91. (Gromada N.E. Changes in the levels of cytokines and indices of kariometrii in infants with perinatal hypoxia. Ros immunol zhurn 2008; 3:87—91.)
11. Kassal R, Anwar M., Kashlan F. et al. Umbilical vein interleukin-6 levels in very low birth weight infants developing intraventricular hemorrhage. Brain Dev 2005; 27: 483—487.
12. Clarke M., Newton R.W., Klapper RE. et al. Chid-hood encephalopathy: viruses, immune response, and outcome. Dev Med Chid Neurol 2006; 48: 6: 294-300.
13. Aly H, Khashaba M.T., ElAyouty M. et al. IL-lbeta, IL-6, and TNF-alpha and outcomes of neonatal hypoxic ischemic encephalopathy. Brain Dev 2006; 28: 3: 178—182.
Review
For citations:
Chistyakova G.N., Remizova L.L., Gazieva L.A., Bychkova S.V., Zanina E.V., Charipova B.T. Pro- and anti-inflammatory mediators in neonates with perinatal pathology. Rossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics). 2014;59(2):66-70. (In Russ.)
Views:
809
Email this article 