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Chronic kidney disease in children: pathogenetic mechanisms and new approaches to the diagnosis of tubulointerstitial fibrosis
https://doi.org/10.21508/1027-4065-2025-70-2-19-29
Abstract
Chronic kidney disease is the outcome of progressive chronic kidney diseases. Chronic kidney disease has a special social significance, affecting the quality of life and life expectancy and life expectancy. Early detection of children and adolescents with chronic kidney diseases and early stages of chronic kidney disease will not only slow down the progression, but also prevent the loss of kidney function. The article presents the main pathogenetic factors influencing the formation and progression of tubulointerstitial fibrosis — arterial hypertension with impaired general and local renal hemodynamics, proteinuria, ischemia, impaired normal functioning of the endothelial barrier, molecular genetic markers; the role of mast cells in the pathogenesis of renal fibrosis, nephrosclerosis.
About the Authors
S. A. Chesnokova
Orenburg State Medical University
Russian Federation
Russian Federation
Orenburg
D. A. Atiakshin
Patrice Lumumba Peoples’ Friendship University of Russia
Russian Federation
Russian Federation
Moscow
A. A. Vyalkova
Orenburg State Medical University
Russian Federation
Russian Federation
Orenburg
N. O. Davydova
Orenburg State Medical University
Russian Federation
Russian Federation
Orenburg
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For citations:
Chesnokova S.A., Atiakshin D.A., Vyalkova A.A., Davydova N.O. Chronic kidney disease in children: pathogenetic mechanisms and new approaches to the diagnosis of tubulointerstitial fibrosis. Rossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics). 2025;70(2):19-29. (In Russ.) https://doi.org/10.21508/1027-4065-2025-70-2-19-29
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