Insulin-like growth factor-1 in the assessment of the current nutritional status in infants with congenital heart disease
Abstract
Objective: To determine the diagnostic value of insulin-like growth factor-1 (IGF-1) as a trophic marker in children with congenital heart disease (CHD) in the pre- and postoperative periods. The study included 149 CHD patients operated on at the N.F. Filatov City Children's Clinical Hospital Thirteen. The patients were divided into age groups: 1) 0 day to 12 months; 2) 1 to 3 years. IGF-I levels were measured in all the children before surgery, on days 2 and 5, and 6+0,5 months after surgery. Before surgery, 22,8% of the patients had a body weight Z-score of <—2SD; 11,4%, a height/age Z-score; 8,7%, a body mass index Z-score. IGF-I was lower for age in 53 (35,6%) children, <25 ng/ml (<25-65,0 ng/ml) in the patients of the first year of fife, and 68,65 ng/ml (<25—202,0 ng/ml) in those aged over 1 year. Six months after hospital discharge, there was a statistically significant (/K0,05) increase in IGF-I concentrations, which correlated with body mass index (r=0,501; /K0,01) and indicated a significant nutritional improvement in the examinees. Thus, the children with CHD showed the changed levels of IGF-I, which appeared as its low preoperative concentration in 40,7% of the patients of the first year of fife and in 23,9% of those aged 1 to 3 years. The follow-up study indicated that effective nutritional support caused 2,4-and 1,6-fold increases in this factor in the children aged 0—1 years and in those aged over 1 year, respectively, which correlated with increased body mass index. The findings give grounds to use this factor in the assessment of nutritional status in children with CHD.
About the Authors
A. I. Chubarova
N.I. Pirogov Russian National Research Medical University
Russian Federation
Russian Federation
S. R. Biryukova
N.F. Filatov City Children's Clinical Hospital Thirteen, Moscow
Russian Federation
Russian Federation
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Review
For citations:
Chubarova A.I., Biryukova S.R. Insulin-like growth factor-1 in the assessment of the current nutritional status in infants with congenital heart disease. Rossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics). 2014;59(2):83-88. (In Russ.)
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