Preview

Rossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics)

Advanced search
Open Access Open Access  Restricted Access Subscription or Fee Access

Features of the course of bronchial asthma in a child with Charge–Strauss syndrome

https://doi.org/10.21508/1027-4065-2025-70-5-97-103

Abstract

This paper presents a clinical case of a child who has been observed since the age of 6 months for13 years and describes the progression of eosinophilic granulomatosis with polyangiitis (Charge-Strauss syndrome). This case demonstrates the diagnosis challenges in the child with severe asthma and highlights the need to expand the knowledge of health care professionals in this field (pediatricians, rheumatologists, pulmonologists, allergologists, immunologists, dermatologists).

About the Authors

G. M. Zainetdinova
Republican Children’s Hospital
Russian Federation

420138, Kazan



R. F. Khakimova
Kazan State Medical University
Russian Federation

420012, Kazan



G. R. Ryzhova
Republican Children’s Hospital
Russian Federation

420138, Kazan



References

1. Emmi G., Bettiol A., Gelain E., Bajema I.M., Berti A., Burns S., et al. Evidence-Based Guideline for the diagnosis and management of eosinophilic granulomatosis with polyangiitis. Nat Rev Rheumatol. 2023; 19(6): 378–393. DOI: s41584-023-00958-w

2. Jakes R.W., Kwon N., Nordstrom B., Goulding R., Fahrbach K., Tarpey J., et al. Burden of illness associated with eosinophilic granulomatosis with polyangiitis: a systematic literature review and meta-analysis. Clin Rheumatol. 2021; 40(12): 4829–4836. DOI: 10.1007/s10067-021-05783-8

3. Watts R.A., Hatemi G., Burns J.C., Mohammad A.J. Global epidemiology of vasculitis. Nat Rev Rheumatol. 2022; 18(1): 22–34. DOI:s41584-021-00718-8

4. Lee J.H., Hong S.H., Yu I., Chang M.S., Park S., Lee S.J., et al. Incidence, Prevalence, and Mortality of Eosinophilic Granulomatosis With Polyangiitis in Korea: A Nationwide Population-Based Study. Allergy Asthma Immunol Res. 2024; 16(2): 168. DOI: 10.4168/aair.2024.16.2.168

5. Fina A., Dubus J., Tran A., Derelle J., Reix P., Fayon M., et al. Eosinophilic granulomatosis with polyangiitis in children: Data from the French RespiRare® cohort. Pediatric Pulmonology. 2018; 53(12): 1640–1650. DOI: 10.1002/ppul.24089

6. Liu X., Wang L., Zhou K., Hua Y., Shi X., Wang C. A delayed diagnosis of eosinophilic granulomatosis with polyangiitis complicated with extensive artery occlusion of lower extremities in children: case report and literature review. Pediatr Rheumatol. 2019; 17(1): 26. DOI: 10.1186/s12969-019-0331-8

7. Theofilis P., Vordoni A., Koukoulaki M., Vlachopanos G., Kalaitzidis R.G. Overview of infections as an etiologic factor and complication in patients with vasculitides. Rheumatol Int. 2022; 42(5): 759–770

8. Hu J.K., Yaghi M., Milikowski C., Elman S.A. Eosinophilic granulomatosis and polyangiitis unmasked by dupilumab. Int J Dermatology. 2023; 62(6): 839–840. DOI: 10.1111/ijd.16670

9. Alexander G., Moore S.A., Lenert P.S. Eosinophilic granulomatosis with polyangiitis and its association with montelukast: a case-based review. Clin Rheumatol. 2024; 43(6): 2153–2165. DOI: 10.1007/s10067-024-07000-8

10. Wieczorek S., Hellmich B., Gross W.L., Epplen J.T. Associations of Churg-Strauss syndrome with the HLA–DRB1 locus, and relationship to the genetics of antineutrophil cytoplasmic antibody–associated vasculitides: Comment on the article by Vaglio et al. Arthritis & Rheumatism. 2008; 58(1): 329–330. DOI: 10.1002/art.23209

11. Tsurikisawa N., Oshikata C., Watanabe M., Tsuburai T., Kaneko T., Saito H. Innate immune response reflects disease activity in eosinophilic granulomatosis with polyangiitis. Clin Experimental Allergy. 2018; 48(10): 1305–1316. DOI: 10.1111/cea.13209

12. Zwerina J., Bach C., Martorana D., Jatzwauk M., Hegasy G., Moosig F., et al. Eotaxin-3 in Churg-Strauss syndrome: a clinical and immunogenetic study. Rheumatology. 2011; 50(10): 1823–1827. DOI: 10.1093/rheumatology/keq445

13. Vega Villanueva K.L., Espinoza L.R. Eosinophilic Vasculitis. Curr Rheumatol Rep. 2020; 22(1): 5. DOI: 10.1007/s11926-020-0881-2

14. Mukherjee M., Thomas S.R., Radford K., Dvorkin-Gheva A., Davydchenko S., Kjarsgaard M., et al. Sputum Antineutrophil Cytoplasmic Antibodies in Serum Antineutrophil Cytoplasmic Antibody–Negative Eosinophilic Granulomatosis with Polyangiitis. Am J Respir Crit Care Med. 2019; 199(2): 158–170. DOI: 10.1164/rccm.201804-0809OC

15. Fukuchi M., Kamide Y., Ueki S., Miyabe Y., Konno Y., Oka N., et al. Eosinophil ETosis–Mediated Release of Galectin-10 in Eosinophilic Granulomatosis With Polyangiitis. Arthritis & Rheumatology. 2021; 73(9): 1683–1693. DOI: 10.1002/art.41727

16. Khoury P., Grayson P.C., Klion A.D. Eosinophils in vasculitis: characteristics and roles in pathogenesis. Nat Rev Rheumatol. 2014; 10(8): 474–483

17. Fagni F., Bello F., Emmi G. Eosinophilic Granulomatosis With Polyangiitis: Dissecting the Pathophysiology. Front Med. 2021; 8: 627776

18. Fijolek J., Radzikowska E. Eosinophilic granulomatosis with polyangiitis — Advances in pathogenesis, diagnosis, and treatment. Front Med. 2023 3; 10: 1145257

19. Cottin V., Bel E., Bottero P., Dalhoff K., Humbert M., Lazor R., et al. Revisiting the systemic vasculitis in eosinophilic granulomatosis with polyangiitis (Churg-Strauss). Autoimmunity Reviews. 2017; 16(1): 1–9

20. Berti A., Volcheck G.W., Cornec D., Smyth R.J., Specks U., Keogh K.A. Severe/uncontrolled asthma and overall survival in atopic patients with eosinophilic granulomatosis with polyangiitis. Respiratory Medicine. 2018; 142: 66–72

21. Wludarczyk A., Szczeklik W. Neurological manifestations in ANCA-associated vasculitis — assessment and treatment. Expert Review of Neurotherapeutics. 2016; 16(8): 861–3. DOI: 10.1586/14737175.2016.1165095

22. Micheletti R.G., Chiesa Fuxench Z., Craven A., Watts R.A., Luqmani R.A., Merkel P.A., et al. Cutaneous Manifestations of Antineutrophil Cytoplasmic Antibody–Associated Vasculitis. Arthritis & Rheumatology. 2020; 72(10): 1741–1747. DOI: 10.1002/art.41310

23. Durel C.A., Sinico R.A., Teixeira V., Jayne D., Belenfant X., Marchand-Adam S., et al. Renal involvement in eosinophilic granulomatosis with polyangiitis (EGPA): a multicentric retrospective study of 63 biopsy-proven cases. Rheumatology (Oxford). 2021; 60(1): 359–365

24. Kuznetsova A.S., Melnik S.I., Gavrilov P.V., Sergeyev K.V., Trusova O.V. Features of diagnostic search in Churg–Strauss syndrome. Case report. Pediatr Con Med. 2023 Dec 2; (2): 198–204. (in Russ)

25. DOI: 10.26442/26586630.2023.2.202314

26. Nie N., Liu L., Bai C., Wang D., Gao S., Liu J., et al. Eosinophilic granulomatous polyangiitis with central nervous system involvement in children: a case report and literature review. Front Immunol. 2024; 15: 1406424

27. Bronchial asthma. Clinical guidelines, 2024 https://cr.minzdrav.gov.ru/view-cr/359_3 Ссылка активна на 25.07.2025

28. Jariwala M., Laxer R.M. Childhood GPA, EGPA, and MPA. Clin Immunol. 2020; 211: 108325. DOI: 10.1016/j.clim.2019.108325

29. Barbosa Rodrigues A., Oliveira-Ramos F., Ferreira R., Camilo C., Oliveira T., Costa-Reis P. Eosinophilic Granulomatosis with Polyangiitis — description of a pediatric patient with severe disease. ARP Rheumatol. 2023; 2(2): 160–165

30. Lev N.S. Eosinophilic granulomatosis with polyangiitis (Churg–Strauss syndrome). In: Clinical variants of interstitial lung diseases in childhood. Lev N.S., Mizernitsky Yu.L. M.: «Medpraktika-M», 2021: 153–160. (in Russ)

31. Cottin V., Bel E., Bottero P., Dalhoff K., Humbert M., Lazor R., et al. Respiratory manifestations of eosinophilic granulomatosis with polyangiitis (Churg–Strauss). Eur Respir J. 2016; 48(5): 1429–1441. DOI: 10.1183/13993003.00097-2016


Review

For citations:


Zainetdinova G.M., Khakimova R.F., Ryzhova G.R. Features of the course of bronchial asthma in a child with Charge–Strauss syndrome. Rossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics). 2025;70(5):97-103. (In Russ.) https://doi.org/10.21508/1027-4065-2025-70-5-97-103

Views: 9


ISSN 1027-4065 (Print)
ISSN 2500-2228 (Online)