Topical application of bacteriophages for the treatment of osteomyelitis caused by Staphylococcus aureus
https://doi.org/10.21508/1027-4065-2025-70-6-29-35
Abstract
This review analyzes scientific publications and presents current views on the use of bacteriophages for the treatment of infections localized in bone tissue, in particular, osteomyelitis (hereinafter referred to as OMT). The stages of the development of the infectious process, the features of bacterial invasion characteristic of bone tissue, and the mechanisms of protection of bacterial cells, which are the most common causative agents of OHT, are briefly considered. Protective mechanisms such as biofilm formation and the formation of new phenotypes inside microbial colonies significantly reduce the effectiveness of the immune system and antibacterial therapy. Long-term survival of pathogens leads to significant damage to surrounding tissues and loss of bone mass.
Bacteriophages are a unique therapeutic reserve, they have a different mechanism of resistance development from antibacterial drugs, are highly specific, capable of eradicating biofilms and infecting pathogens with an altered phenotype. In our review, we came to the conclusion that, despite the proven effectiveness of the use of bacteriophages in individual studies, the technique is at the stage of study and cannot be scaled up to the industry standard, further research is required.
About the Authors
V. A. Zingis
Voino-Yasenetsky Scientific Center for Specialized Medical Care for Children ; Russian Peoples’ Friendship University
Russian Federation
Russian Federation
119620, Moscow
117198, Moscow
R. A. Keshishyan
Voino-Yasenetsky Scientific Center for Specialized Medical Care for Children ; Russian Peoples’ Friendship University
Russian Federation
Russian Federation
119620, Moscow
117198, Moscow
I. A. Shavyrin
Voino-Yasenetsky Scientific Center for Specialized Medical Care for Children
Russian Federation
Russian Federation
119620, Moscow
I. V. Tsibikov
Voino-Yasenetsky Scientific Center for Specialized Medical Care for Children
Russian Federation
Russian Federation
119620, Moscow
M. A. Chinikov
Russian Peoples’ Friendship University
Russian Federation
Russian Federation
117198, Moscow
I. V. Kopylov
tate Budgetary Institution of Health Care of the City of Moscow «Morozovskaya Children’s City Clinical Hospital of the Moscow Health Department»
Russian Federation
Russian Federation
Moscow
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Review
For citations:
Zingis V.A., Keshishyan R.A., Shavyrin I.A., Tsibikov I.V., Chinikov M.A., Kopylov I.V. Topical application of bacteriophages for the treatment of osteomyelitis caused by Staphylococcus aureus. Rossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics). 2025;70(6):29-35. (In Russ.) https://doi.org/10.21508/1027-4065-2025-70-6-29-35
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