Long-term effects of iron, vitamin E, and folate on hematopoiesis red germ parameters in preterm infants
https://doi.org/10.21508/1027-4065-2025-70-6-36-43
Abstract
Early anemia of premature infants is one of the most common pathological conditions found in premature newborns. Currently, there are still relevant studies aimed at identifying new methods of conservative correction of anemia in premature newborns in order to prevent the progression of this pathological process and reduce the frequency of invasive methods of correction of severe anemia syndrome.
The aim of the study was to evaluate the comparative effectiveness of iron, vitamin E and folic acid as drugs of choice for the prevention and treatment of early anemia in premature infants.
Materials and methods. The study included 85 premature infants at risk of developing early anemia who were treated in the Department of Pathology of newborns and premature infants. As part of the standard protocol for the treatment and care of this contingent of children, medications (vitamin E, folic acid, iron preparations) were prescribed in appropriate preventive dosages. Within the prescribed time limits — 3 months, 6 months, 9 months and 12 months — the children included in the study were assessed for hemoglobin, erythrocytes and ferritin levels.
The results of the study. It was found that in the long term, the use of iron preparations at a dose of 2 mg/kg/day to prevent the development of early anemia in premature newborns was most effective (ferritin values by the end of the 7th week of life in this group of children had the highest values, p<0.05). With regard to the use of vitamin E and folic acid, the opposite dynamics were observed — in newborns who did not receive these medications on a routine basis, the indicators of ferritin, erythrocytes, hemoglobin and hematocrit prevailed or remained in equal values with similar indicators in children who received these medications on a routine basis (p<0.05).
Conclusion. The most effective doses of drugs that are routinely used as drugs of choice for the prevention of early anemia in newborns have been determined.
About the Authors
N. V. Korotaeva
Burdenko Voronezh State Medical University ; Voronezh Regional Clinical Hospital № 1
Russian Federation
Russian Federation
394036, Voronezh
394066, Voronezh
L. I. Ippolitova
Burdenko Voronezh State Medical University
Russian Federation
Russian Federation
394036, Voronezh
References
1. Rocha G., Pereira S., Antunes-Sarmento J., Flôr-de-Lima F., Soares H., Guimarães H. Early anemia and neonatal morbidity in extremely low birth-weight preterm infants. J Matern Fetal Neonatal Med. 2021; 34 (22): 3697–3703. DOI: 10.1080/14767058.2019.1689948
2. Shavaeva K.A., Beremukova M.A., Pogorova M.R., Zhidkov R.S. Early Anemia of Prematurity: Etiology, Clinical Presentation, and Diagnosis. Voprosy nauki i obrazovanija. 2022; 1(157): 38–41 (in Russ)
3. Ivanenkova Ju.A., Harlamova N.V., Kuz’menko G.N., Matveeva E.A. Factors Influencing the Development of Early Anemia of Prematurity. Medicina: teorija i praktika. 2019; 4 (5): 227 (in Russ)
4. Lazareva V.V., Narogan M.V., Vedixina I.A., Ivanecz T.Yu., Zubkov V.V., Ryumina I.V. et al. Folic acid supply for extremely premature infants under modern conditions of care and feeding. Neonatologiya: novosti, mneniya, obuchenie. 2022; 10 (4): 8–16 (in Russ) DOI: 10.33029/2308-2402-2022-10-4-8-16
5. Maljuzhinskaja N.V., Petrova I.V., Chebatkova A.V., Polyakova O.V., Bol`shakova O.V. Modern Approaches to the Treatment of Early Anemia in Premature Infants. Lekarstvennyj vestnik. 2023; 24 (2): 19–21 (in Russ)
6. Wang X., Jing J., Huang S., He X., Gao P., Li H., et al. Relationship of Early Anemia with Neurodevelopment and Brain Injury in Very Low Birth Weight Preterm Infants-A Prospective Cohort Study. Nutrients. 2022; 14 (22): 4931. DOI: 10.3390/nu14224931
7. Skubisz A., de Vries L.S., Jansen S.J., Van der Staaij H., Lopriore E., Steggerda S.J. Early red blood cell transfusion and the occurrence of intraventricular hemorrhage in very preterm infants. Early Hum Dev. 2024; 189 (1): 105926. DOI: 10.1016/j.earlhumdev.2023.105926
8. Sundararajan S., Rabe H. Prevention of iron deficiency anemia in infants and toddlers. Pediatr Res. 2021; 89 (1): 63–73. DOI: 10.1038/s41390-020-0907-5
9. Gomez-Pomar E., Hatfield E., Garlitz K., Westgate P.M., Bada H.S. Vitamin E in the Preterm Infant: A Forgotten Cause of Hemolytic Anemia. Am J Perinatol. 2018; 35 (3): 305–310. DOI: 10.1055/s-0037-1607283
10. Ree I., Smits-Wintjens V., Bom J., Van Klink J.M., Oepkes D., Lopriore E. Neonatal management and outcome in alloimmune hemolytic disease. Expert Rev Hematol. 2017; 10 (7): 607–616. DOI: 10.1080/17474086.2017.1331124
11. Haiden N., Klebermass K., Cardona F., Schwindt J., Berger A., Kohlhauser-Vollmuth C., et al. A randomized, controlled trial of the effects of adding vitamin B12 and folate to erythropoietin for the treatment of anemia of prematurity. Pediatrics. 2006; 118 (1): 180–188. DOI: 10.1055/s-2006-946031
12. Zhao B., Sun M., Wu T., Li J., Shi H., Wei Y. The association between maternal anemia and neonatal anemia: a systematic review and meta-analysis. BMC Pregnancy Childbirth. 2024; 24 (1): 677. DOI: 10.1186/s12884-024-06832-1
13. Reibel-Georgi N., Scrivens A., Heeger L., Lopriore E., New H.V., Deschmann E., et al. Neonatal Transfusion Network. Supplemental Iron and Recombinant Erythropoietin for Anemia in Infants Born Very Preterm: A Survey of Clinical Practice in Europe. J Pediatr. 276 (1): 114302. DOI: 10.1016/j.jpeds.2024.114302
14. Ruan S., Li J., Xiong F., Lu Y., Yang S., Tang Z., et al. The effect of iron supplementation in preterm infants at different gestational ages. BMC Pediatr. 2024; 24 (1): 530. DOI: 10.1186/s12887-024-04996-5
15. Costescu O., Manea A., Cioboata D., Doandes F.M., Zaharie M., Dinu M., et al. The Effects of Iron Administration on Anemia Development during the 7th and 21st Day of Life in Premature Newborns: A Prospective Cohort Study. Medicina (Kaunas). 2024; 60 (5): 684. DOI: 10.3390/medicina60050684
Review
For citations:
Korotaeva N.V., Ippolitova L.I. Long-term effects of iron, vitamin E, and folate on hematopoiesis red germ parameters in preterm infants. Rossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics). 2025;70(6):36-43. (In Russ.) https://doi.org/10.21508/1027-4065-2025-70-6-36-43
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