Clinical and laboratory features of the course of measles in children

Abstract

Purpose of the study. The analysis of the frequency of elevated liver enzymes in children with measles during the course of the disease. Materials and methods. We conducted an analysis and statistical processing of 523 medical histories of children aged from 2 months to 17 years, hospitalized with a diagnosis of «Measles» in the children’s infectious disease ward of MMCC «Kommunarka», for the period from January 2023 to March 2024. Results. Upon admission to the children’s infectious disease ward with a diagnosis of «Measles» biochemical blood analysis was performed on 521 children. We found that an increase in transaminases up to 5 times or more above normal was observed in 35 children, accounting for 6.7% of the total number of children. The highest number of children with elevated liver enzymes up to 5 or more times normal was among those aged 12 to 17 years — 21 children, which is 60%. However, this elevation was asymptomatic and did not affect the course or duration of the illness. Conclusion. Given the ongoing epidemic instability in the measles incidence, further monitoring of clinical and laboratory data will allow for the development of optimal clinical and diagnostic algorithms for managing patients with measles.