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Metabolomic markers of bronchial asthma in children under the conditions of the atopic march: a review of cohort studies
https://doi.org/10.21508/1027-4065-2026-71-1-16-22
Abstract
Currently, interest in the field of metabolomics of allergic diseases, including bronchial asthma, is quite high. However, there is insufficient data aimed at uncovering the mechanisms of pathogenesis of the atopic march and the development of bronchial asthma, including those confirmed in different populations of children. Metabolomic studies can reveal early biochemical changes that can predict the development of bronchial asthma.
The aim of the study is to analyze the results of cohort studies aimed at studying metabolic markers that can predict the risk of developing bronchial asthma in the context of the atopic march.
Materials and methods. Search for publications in Medline databases and Scientific Electronic Library. Publication dates: January 2015 - May 2025; cohort studies aimed at finding metabolomic markers that can predict the risk of developing bronchial asthma in the context of the implementation of the atopic march were included.
Results. This review includes 6 publications. The data on changes in metabolic profiles associated with the development of bronchial asthma in children are summarized.
Conclusion: Changes in the metabolism of lipids, amino acids, bile acids, and energy metabolism detected in umbilical cord blood, blood plasma, and urine of newborns and young children precede the clinical manifestations of atopic diseases and can serve as a basis for predicting the risk of developing bronchial asthma.
Supporting agencies: This work was supported by the Research Foundation Flanders (grant No. 25-15-00576)
About the Authors
T. S. Sokolova
Siberian State Medical University
Russian Federation
Russian Federation
634050, Tomsk
K. A. Kuanysheva
Siberian State Medical University
Russian Federation
Russian Federation
634050, Tomsk
I. Yu. Shevelev
Siberian State Medical University
Russian Federation
Russian Federation
634050, Tomsk
D. S. Sobakin
Siberian State Medical University
Russian Federation
Russian Federation
634050, Tomsk
O. S. Fedorova
Siberian State Medical University
Russian Federation
Russian Federation
634050, Tomsk
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Review
For citations:
Sokolova T.S., Kuanysheva K.A., Shevelev I.Yu., Sobakin D.S., Fedorova O.S. Metabolomic markers of bronchial asthma in children under the conditions of the atopic march: a review of cohort studies. Rossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics). 2026;71(1):16-22. (In Russ.) https://doi.org/10.21508/1027-4065-2026-71-1-16-22
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