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Neurotoxicity of general anesthesia in children with psychoneurological pathology: current state of the problem
https://doi.org/10.21508/1027-4065-2026-71-2-25-33
Abstract
Neurotoxicity of general anaesthesia drugs has been a subject of debate and research for two decades. Of particular concern is the possible neurotoxic effect of anaesthesia on the developing CNS in young children, as well as in children with psychoneurological disorders. The results of preclinical animal studies demonstrate the neurotoxicity of most known anaesthesia drugs, which is manifested both at the microscopic level and in the form of clinically significant impairments of cognitive and behavioural functions. However, the question of extrapolation of experimental data to humans remains open. Clinical studies on the neurotoxicity of general anaesthesia show contradictory results. The effect of xenon anaesthesia on the cognitive functions of the paediatric population in general, and especially children with neuropsychiatric pathology, remains poorly studied. According to the data acquired in experimental and clinical studies, the innovative anaesthetic xenon demonstrates neuroprotective effects, which suggests the absence of neurotoxicity and opens prospects for it's use in patients with a particularly vulnerable central nervous system.
About the Authors
E. A. Adkina
Voino-Yasenetsky Scientific Center for Specialized Medical Care for Children ; Pirogov Russian National Research Medical University
Russian Federation
Russian Federation
119620, Moscow
117513, Moscow
V. V. Lazarev
Voino-Yasenetsky Scientific Center for Specialized Medical Care for Children ; Pirogov Russian National Research Medical University
Russian Federation
Russian Federation
119620, Moscow
117513, Moscow
A. I. Krapivkin
Voino-Yasenetsky Scientific Center for Specialized Medical Care for Children ; Pirogov Russian National Research Medical University
Russian Federation
Russian Federation
119620, Moscow
117513, Moscow
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For citations:
Adkina E.A., Lazarev V.V., Krapivkin A.I. Neurotoxicity of general anesthesia in children with psychoneurological pathology: current state of the problem. Rossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics). 2026;71(2):25-33. (In Russ.) https://doi.org/10.21508/1027-4065-2026-71-2-25-33
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