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Coinfection caused by hepatitis C virus and human pegivirus in an 11-year-old teenager with aplastic anemia
https://doi.org/10.21508/1027-4065-2026-71-2-110-113
Abstract
Chronic hepatitis C is an urgent problem for Russian healthcare, including in pediatric practice. Currently, this infection can be successfully treated with the use of direct antiviral drugs. However, in some cases, due to the common ways of infection, especially with hemotransfusions, there is an infection caused by the hepatitis C virus and human pegivirus, the role of which is still not completely clear. A clinical observation from our own practice demonstrates the effectiveness of glecaprevir/pibrentasvir in an 11-year-old coinfected patient who received multiple blood transfusions against hepatitis C virus while maintaining pegivirus replication, which may have negatively affected the course of concomitant hematological disease.
About the Authors
O. N. Kandoba
Research clinical institute of childhood
Russian Federation
Russian Federation
115093, Moscow
V. A. Greshnyakova
Federal Research and Clinical Center for Infectious Diseases ; Saint-Petersburg State Pediatric Medical University ; St. Petersburg State University
Russian Federation
Russian Federation
197022, St. Petersburg
194100, St. Petersburg
199106, St. Petersburg
S. G. Gorbunov
Research clinical institute of childhood ; Russian Medical Academy of Continuing Professional Education
Russian Federation
Russian Federation
115093, Moscow
125993, Moscow
N. D. Odinaeva
Research clinical institute of childhood ; M.F. Vladimirsky Moscow Regional Research and Clinical Institute
Russian Federation
Russian Federation
115093, Moscow
129110, Moscow
References
1. Jarasvaraparn C., Hartley C., Karnsakul W. Updated clinical guidelines on the management of hepatitis C infection in children. Pathogens. 2024; 13(2): 180. DOI: 10.3390/pathogens13020180
2. Melikoki V., Kourlaba G., Kanavaki I., Fessatou S., Papaevangelou V. Seroprevalence of hepatitis C in children without identifiable risk-factors: a systematic review and meta-analysis. J. Pediatr. Gastroenterol. Nutr. 2021; 72(6): 140. DOI: 10.1097/MPG.0000000000003099
3. Schmelzer J., Dugan E., Blach S., Coleman S., Cai Z., DePaola M. еt al. Global prevalence of hepatitis C virus in children in 2018: A modelling study. Lancet Gastroenterol. Hepatol. 2020; 5: 374–392. DOI: 10.1016/S2468-1253(19)30385-1
4. Malik F., Bailey H., Chan P., Mozalevskis A., Thorne C., Easterbrook P. Where are the children in national hepatitis C policies? A global review of national strategic plans and guidelines. JHEP Rep. 2021; 3(2): 2100227. DOI: 10.1016/j.jhepr.2021.100227
5. Hong S.-J., Choe B.-H. Strategies for treating and managing chronic hepatitis C in children in the direct-acting antiviral era. Clin. Exp. Pediatrics. 2020; 63(2): 46–47. DOI: 10.3345/kjp.2019/01116
6. Goh L., Hardikar W. Hepatitis C in children — an Asia-Pacific concise perspective. Pathogens. 2024; 13(10): 860. DOI: 10.3390/pathogens13100860
7. Kerkar N., Hartjes K. Hepatitis C virus — pediatric and adult perspectives in the current decade. Pathogens. 2025; 14(1): 11. DOI: 10.3390/pathogens14010011
8. Yu Y., Wan Z., Wang J.-H., Yang X., Zhang C. Rewiew of human pegivirus: prevalence, pathogenesis, transmission, and clinical implication. Virulence. 2022; 13, Issue 1: 323–340. DOI: 10.1080/21505594.2022.2029328
9. Komatsu H., Fujisawa T., Inui A. GBV-C/HGV does not seem to affect the clinical course of young patients with chronic hepatitis C. J. Med. Virol. 1999; 59: 154–159
10. Alter H.J., Nakatsuji Y., Melpolder J., Wages J., Wesley R., Wai-Kuo Shih J., Kim J.P. The incidence of transfusion-associated hepatitis G virus infection and its relation to liver disease. N. Engl. J. Med. 1997; 336(11): 747–754. DOI: 10.1056/NEJM199703133361102
Review
For citations:
Kandoba O.N., Greshnyakova V.A., Gorbunov S.G., Odinaeva N.D. Coinfection caused by hepatitis C virus and human pegivirus in an 11-year-old teenager with aplastic anemia. Rossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics). 2026;71(2):110-113. (In Russ.) https://doi.org/10.21508/1027-4065-2026-71-2-110-113
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