Microalbuminuria and P2-microglobulinuria in children with vesicoureteral reflux and reflux nephropathy
Abstract
The urinary levels of mlcroalbumin and P2-mlcroglobulin were determined in 71 patients aged 1 to 14 years with vesicoureteral reflux. According to the degree of reflux nephropathy as evidenced by dimercaptosuccinic acid (DMSA) scintigraphy, the patients were divided into 3 groups: 9 patients without reflux nephropathy (Group 2); 41 with mild reflux nephropathy (Group 3); and 21 with severe reflux nephropathy (Group 4). A control group (Group 1) consisted of 29 healthy children without a history of kidney disease. Mi-croalbumin and P2-microglobulin from the morning urine portions were determined by enzyme-linked immunosorbent assay (ELISA) and recalculated with reference to urinary creatinine. A relationship was found between the urinary levels of proteins and the severity of reflux nephropathy. There was a significant rise in urinary microalbumin and P2-microglobulin excretion levels in severe reflux nephropathy. This permits the use of this study in patients with reflux nephropathy as a diagnostic marker of its severity.
About the Authors
N. M. Zaicova
Institute of Mother and Child Care, Kishinev, Moldova
Moldova, Republic of
Moldova, Republic of
V. V. Dlin
Research Clinical Institute of Pediatrics, Moscow
Russian Federation
Russian Federation
L. A. Sinitsyna
Institute of Mother and Child Care, Kishinev, Moldova
Moldova, Republic of
Moldova, Republic of
V. S. Gudumac
Institute of Mother and Child Care, Kishinev, Moldova
Moldova, Republic of
Moldova, Republic of
A. A. Korsunsky
I.M. Sechenov First Moscow State Medical University
Russian Federation
Russian Federation
Sh. G. Gackan
Institute of Mother and Child Care, Kishinev, Moldova
Moldova, Republic of
Moldova, Republic of
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Review
For citations:
Zaicova N.M., Dlin V.V., Sinitsyna L.A., Gudumac V.S., Korsunsky A.A., Gackan Sh.G. Microalbuminuria and P2-microglobulinuria in children with vesicoureteral reflux and reflux nephropathy. Rossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics). 2014;59(5):69-76. (In Russ.)
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