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Congenital infection caused by lymphocytic choriomeningitis virus: little-known problem in modern perinatal medicine
H. A. Sarkisyan,
L. D. Vorona,
D. M. Muscherova,
A. I. Vavilova,
K. S. Zizyukina,
A. I. Krapivkin,
P. V. Shumilov https://doi.org/10.21508/1027-4065-2026-71-3-16-25
Abstract
Congenital infections play a significant role in perinatal pathology. Of particular interest is the lymphocytic choriomeningitis virus (Lymphocytic choriomeningitis, ICD-10: A87.2), which has pronounced neurotropic and teratogenic effects. Congenital infection caused by the lymphocytic choriomeningitis virus is characterized by microcephaly, hydrocephalus, periventricular calcifications, and visual and auditory lesions. Diagnosis is based on the identification of characteristic structural abnormalities during prenatal screening ultrasound and confirmation of the viral etiology of the disease. Specific antiviral drugs and vaccines against the lymphocytic choriomeningitis virus are currently unavailable, so treatment is supportive. Approximately one-third of newborns die in infancy, and survivors develop persistent neurological and ophthalmological disorders. Given the underestimated prevalence of this virus, this work aims to systematize current data on the pathogenesis, clinical features, diagnosis, and prognosis of congenital infection caused by the lymphocytic choriomeningitis virus.
About the Authors
H. A. Sarkisyan
Pirogov Russian National Research Medical University
Russian Federation
Russian Federation
117997, Moscow
L. D. Vorona
Pirogov Russian National Research Medical University; V.F. Voyno-Yasenetsky Scientific and Practical Center of Specialized Medical Care for Children
Russian Federation
Russian Federation
117997, Moscow
119620, Moscow
D. M. Muscherova
Pirogov Russian National Research Medical University
Russian Federation
Russian Federation
117997, Moscow
A. I. Vavilova
Pirogov Russian National Research Medical University
Russian Federation
Russian Federation
117997, Moscow
K. S. Zizyukina
Pirogov Russian National Research Medical University
Russian Federation
Russian Federation
117997, Moscow
A. I. Krapivkin
V.F. Voyno-Yasenetsky Scientific and Practical Center of Specialized Medical Care for Children
Russian Federation
Russian Federation
119620, Moscow
P. V. Shumilov
Pirogov Russian National Research Medical University
Russian Federation
Russian Federation
117997, Moscow
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For citations:
Sarkisyan H.A., Vorona L.D., Muscherova D.M., Vavilova A.I., Zizyukina K.S., Krapivkin A.I., Shumilov P.V. Congenital infection caused by lymphocytic choriomeningitis virus: little-known problem in modern perinatal medicine. Rossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics). 2026;71(3):16-25. (In Russ.) https://doi.org/10.21508/1027-4065-2026-71-3-16-25
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