Atherosclerosis: Hypotheses and theories
Abstract
The article gives basic theories of the pathogenesis of atherosclerosis, including inflammatory, cholesterol, lipid, lipoprotein, iron ones, as a result of metabolic syndrome, oxidative stress. In spite of carefully and deeply developed and ongoing elaborated pathogenesis theories, the etiological factors of atherosclerosis remain unknown so far. The age-related aspect of the disease is discussed; atherosclerosis is considered to be a childhood-onset disease that manifests itself at a later age. The authors propose an experimental and clinical evidence-based concept of the common etiology of syndromes of atherosclerosis, namely: the body's endogenous intoxication that is permanent or periodically progressive may be a primary cause of altered conformation of different protein molecules with their higher ability to adsorb the trace elements consolidating the structural changes. This change of proteins diminishes their functions and determines their antigenic properties, which is attended by the development of different pathogenic components in relation to the body's individual features.
About the Authors
E. A. Yuryeva
Research Clinical Institute of Pediatrics, Moscow
Russian Federation
Russian Federation
V. S. Sukhorukov
Research Clinical Institute of Pediatrics, Moscow
Russian Federation
Russian Federation
E. S. Vozdvizhenskaya
Research Clinical Institute of Pediatrics, Moscow
Russian Federation
Russian Federation
N. N. Novikova
National Research Center "Kurchatov Institute", Moscow
Russian Federation
Russian Federation
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Review
For citations:
Yuryeva E.A., Sukhorukov V.S., Vozdvizhenskaya E.S., Novikova N.N. Atherosclerosis: Hypotheses and theories. Rossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics). 2014;59(3):6-16. (In Russ.)
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