Celiac disease and associated diseases
Abstract
In accordance with the current definition proposed by the European Society for Pediatric Gastroenterology, Hepatology, and Nutrition (ESPGHAN) in 2012, celiac disease is regarded as an immune-mediated systemic disease caused by gluten and respective prola-mins in genetically predisposed people. Detailed studies of the pathogenesis of gluten enteropathy provided the basis for investigating the possible causes of the common concurrence of celiac disease with a number of autoimmune and endocrine diseases. The possible reasons for the association are considered to be common genetic markers in the patients, a cross reaction of the autoantibodies formed in celiac disease and activated T lymphocytes with the body's intrinsic antigens, as well as the systemic action of proinflam-matory cytokines. Although many issues of pathophysiology remain a matter of debate, the fact that patients suffering from a number of diseases form a group at risk for celiac disease and require a careful follow-up and examination for timely diagnosis and use of gluten-free diet is currently beyond question.
About the Authors
I. N. Zakharova
Russian Medical Academy of Postgraduate Education, Moscow
Russian Federation
Russian Federation
Yu. A. Dmitrieva
Russian Medical Academy of Postgraduate Education, Moscow
Russian Federation
Russian Federation
F. S. Dzebisova
North-Ossetian state Academy, Vladikavkaz
Russian Federation
Russian Federation
References
1. European Society for Pediatric Gastroenterology Hepatology, and Nutrition Guidelines for the Diagnosis of Coeliac Disease. JPGN 2012; 54: 136-160.
2. Aledini A., Green P. Narrative review: celiac disease: understanding a complex autoimmune disorder. Ann Intern Med 2005; 142: 289-298.
3. Collin P., Kaukinen K., Valimaki M. et al. Endocrinological Disorders and Celiac Disease. Endocrine Reviews 2002; 23: 4: 464—483.
4. Saukkonen T, Savilahti E, Reijonen H. et al. Coeliac disease: frequent occurrence after clinical onset of insulin-dependent diabetes mellitus. Diabet Med 1996; 13: 464—470.
5. Cacciari E., Bianchi F.B, Salardi S. et al. Eate development of IgA antiendomycial antibodies and small intestinal mucosal atrophy after insulin dependent diabetes mellitus onset. Arch Dis Child 1997; 77: 465.
6. Valentino R., Savastano S., Maglio M. et al. Markers of potential coeliac disease in patients with Hashimoto's thyroiditis. Eur J Endocrinol 2002; 146:479-483.
7. Zelissen P.M.J., Bast E.J.E., Croughs R.J.M. Associated autoimmunity in Addison's disease. J Autoimmun 1995; 8: 121-130.
8. O'Leary C, Walsh C.H., Wieneke P. et al. Celiac disease and autoimmune Addison's disease: a clinical pitfall. Q J Med 2002; 95:79-82.
9. Sollid L.M. Molecular basis of celiac disease. Annu Rev Immunol 2000; 18: 53-81.
10. Gutierrez-Achury J., CoutinhodeAlmeida R., Wijmenga C. Shared genetics in celiac disease and other immunemediated diseases. J Intern Med 2011; 269: 591—603.
11. Sollid L.M. Coeliac disease: dissecting a complex inflammatory disorder. Nat Rev Immunol 2002; 2: 647—655.
12. Williams A.J.K., Norcross A.J., Lock R.J. et al. The high prevalence of autoantibodies to tissue transglutaminase in first-degree relatives of patients with type 1 diabetes is not associated with islet autoimmunity. Diabetes Care 2001; 24: 504—509.
13. Dalton T.A., Bennett J.C. Autoimmune disease and the major histocompatibility complex: therapeutic implications. Am J Med 1992; 92: 183-188.
14. Petronzelli F., Bonamico M., Ferrante P. et al. Genetic contribution of the HLA region to the familial clustering of coeliac disease. Ann Hum Genet 1997; 61: 307—317.
15. Catassi C, Fasano A. Celiac disease. Current opinion in Gastroenterol 2008; 24: 687—691.
16. Holopainen P., Mustalahti K., Uimari P. et al. Candidate gene regions and genetic heterogeneity in gluten sensitivity. Gut 2001; 48: 696-701.
17. Collin P., Kaukinen K., Valimaki M. et al. Endocrinological Disorders and Celiac Disease. Endocrine Reviews 2002; 23: 4: 464-483.
18. Korponay-Szabo I.R. Pathogenesis of celiac disease. Mat. Of CD-Medics Training Seminar «Coeliac disease aholistic approach». Malta 2009; 8—10.
19. Gomis R., Sener A., Malaisse-Lagae F., Malaisse W.J. Transglutaminase activity in pancreatic islets. Biochim Biophys Acta 1983; 760: 384-388.
20. Cosnes J., Cellier C, Viola S. et al. Incidence of autoimmune diseases in celiac disease: protective effect of the gluten-free diet. Clin Gastroenterol Hepatol 2008; 6: 7: 753—758.
21. Saadah O.I.,ZacharinM., O'CallaghanA. etal. Effectofgluten-freediet and adherence on growth and diabetic control in diabetics with celiac disease. Arch DisChild 2004; 89: 871— 876.
22. Abid N., McGlone O., Cardwell С et al. Clinical and metabolic effects of glutenfree diet in children with type 1 diabetes and celiac disease. Pediatr Diabetes 2011; 12: 322—325.
Review
For citations:
Zakharova I.N., Dmitrieva Yu.A., Dzebisova F.S. Celiac disease and associated diseases. Rossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics). 2014;59(3):44-49. (In Russ.)
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