Prevalence of congenital heart diseases in children at the present stage
Abstract
An extensive meta-analysis of the world literature showed that congenital heart diseases were registered at a rate of 6 per 1,000 live births in 1930—1934 with its increase up to 9,1 per 1,000 after 1995. According to various estimates, the rate of congenital heart diseases was 4 to 10 per 1,000 births after 2000. However, the true prevalence of the above defects may be much higher. Most authors are in agreement that the rate of congenital heart disease varies between 19 to 75 per 1,000 live births; serious anomalies being registered at a rate of 19,1—23,9 per 1,000 births. Many cardiologists do not consider mild defects to be diseases; however, this statement calls for further investigation. Fetal echocardiography and genetic studies are of great importance in estimating the prevalence of congenital heart disease. Tables of chromosomal and monogenic syndromes associated with cardiac malformations are given.
About the Authors
Yu. M. BelozerovRussian Federation
L. V. Bregel
Russian Federation
V. M. Subbotin
Russian Federation
References
1. van derLindeD., Konnings E., SlagerM. etal. Birth prevalence of congenital heart disease worldwide: a systematic review and meta-analysis. J Am Cardiol 2011; 58: 21: 2241—2247.
2. Jones K.L. Smith's Recognizable Patterns of Human Malformation. 6th ed. Philadelphia, Pa: Saunders 2006; 634.
3. Hoffman J.I., Kaplan S. The incidence of congenital heart disease. J Am Coll Cardiol 2002; 39: 1890-1900.
4. Jouannic J.M., Thieulin A. C, Bonnet D. et al. Measurement of nuchal translucency for prenatal screening of congenital heart defects: a population-based evaluation. Prenat Diagn 2001; 31: 13: 1264-1269.
5. Kipps A.K., Feuille C, Azflkie A. et al. Prenatal diagnosis of hypoplastic left heart syndrome in current era. Am J Cardiol 2011; 108:3:421-427.
6. Feinstein J.A., Benson D.W., Dubin A.M. et al. Hypoplastic left heart syndrome: current considerations and expectations. J Am Coll Cardiol 2012; 59: 1 Suppl: Sl-42.
7. Laas E., belong N., Thieulin A. C. et al. Pretem bith and Congenital Heart Defects: Apopulationbased study. Pediatrics 2012; 4: e829-e837.
8. Hoffman J.I., Kaplan S., Liberthson R.R. Prevalence of congenital heart disease. Am Heart J 2004; 147: 425—439.
9. Ward C. Clinical significance of the bicuspid aortic valve. Heart 2000; 83: 81—85.
10. Cripe L., Andelfinger G., Martin L.J. et al. Bicuspid aortic valve is heritable. J Am Coll Cardiol 2004; 44: 138—143.
11. Loffredo С A., Chokkalingam A., Sill A.M. et al. Prevalence of congenital cardiovascular malformations among relatives of infants with hypoplastic left heart, coarctation of the aorta, and d-transposition of the great arteries. Am J Med Genet 2004; 124: 225-230.
12. Lewin M.B., McBride K.L., Pignatelli R. et al. Echocardiographic evaluation of asymptomatic parental and sibling cardiovascular anomalies associated with congenital left ventricular outflow tract lesions. Pediatrics 2004; 114: 691-696.
13. Dolk H, Loane M., Game E. The prevalence of congenital
14. anomalies in Europe. Adv Exp Med Biol 2010; 686: 349—363.
15. Bernstein D. Evaluation of the cardiovascular system. In: Behrman R.E., Kliegman R.M., Jenson H.B. (eds). Nelson Textbook of Pediatrics: Philadelphia, Saunders, 2004:1481—1488.
16. Pierpont M.E., Basson СТ., Benson D.W. et al. Genetic basis for congenital heart defects: current knowledge: a scientific statement from the American Heart Association Congenital Cardiac Defects Committee, Council on Cardiovascular Disease in the Young: endorsed by the American Academy of Pediatrics. Circulation 2007; 115: 23: 3015—3038.
17. Jenkins K, Correa A., Feinstein J. et al. Noninherited risk factors and congenital cardiovascular defects: current knowledge: a scientific statement from the American Heart Association Council on Cardiovascular Disease in the Young: endorsed by the American Academy of Pediatrics. Circulation 2007; 115: 23: 2995-3014.
18. Blue G.M., Kirk E.P., Sholler G.F. et al. Congenital heart disease: current knowledge about causes and inheritance. Med JAust2012; 197:3:155-159.
19. Webb G.D., Williams R.G. Care of the adult with congenital heart disease: introduction. J Am Coll Cardiol 2001; 37: 1166.
20. Williams R.G., Pearson G.D., Barst R.J. et al. National Heart, Lung, and Blood Institute Working Group on Research in Adult Congenital Heart Disease. Report of the National Heart, Lung, and Blood Institute Working Group on research in adult congenital heart disease. J Am Coll Cardiol 2006; 47: 701-707.
21. Houyel L., Khoshnood В., Anderson R.H. et al. £PICARD Study group. Population-based evaluation of a suggested anatomic and clinical classification of congenital heart defects based on the International Paediatric and Congenital Cardiac Code. Orphanet J Rare Dis 2011; 6: 64.
22. Richards A.A., Garg V. Genetics of congenital heart disease. Curr Cardiol Rev 2010; 6: 2: 91—97.
23. Bhardwaj R., Rai S.K, Yadav A.K. et al. Epidemiology of Congenital Heart Disease in India. Congenit Heart Dis 2014; doi: 10.1111/chd.l2220.
Review
For citations:
Belozerov Yu.M., Bregel L.V., Subbotin V.M. Prevalence of congenital heart diseases in children at the present stage. Rossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics). 2014;59(6):7-11. (In Russ.)