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The pattern of autonomic tone disorder and its correction in children with overactive bladder

https://doi.org/10.21508/1027-4065-2014-59-6-71-79

Abstract

Autonomic nervous system dysregulation is one of the leading components in the pathogenesis of neurogenic bladder dysfunction. These disorders lead to diverse changes in the functions of the sympathetic and parasympathetic systems with disordered release of mediators (norepinephrine, acetylcholine), hormones of the adrenal cortex and other endocrine glands, a number of biologically active substances (polypeptides, prostaglandins), as well as to the impaired sensitivity of vascular a- and p-adrenoceptors. Children with dysuria concurrently develop visceral, CNS, and circulatory system dysfunctions and metabolic disturbances. The paper describes the clinical trial of children with overactive bladder, which demonstrates the autonomic tone in these patients (и=44). The findings point to the important involvement of the autonomic nervous system in the pathogenesis of the disease and provide a rationale for the incorporation of vegetotropic drugs normalizing the autonomic nervous system into the combination therapy of overactive bladder.

About the Authors

S. L. Morozov
Research Clinical Institute of Pediatrics, Moscow
Russian Federation


V. V. Dlin
Research Clinical Institute of Pediatrics, Moscow
Russian Federation


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Review

For citations:


Morozov S.L., Dlin V.V. The pattern of autonomic tone disorder and its correction in children with overactive bladder. Rossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics). 2014;59(6):74-78. (In Russ.) https://doi.org/10.21508/1027-4065-2014-59-6-71-79

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ISSN 1027-4065 (Print)
ISSN 2500-2228 (Online)