Evaluation of neuron-specific factors in the diagnostics of organic CNS damage in extremely preterm infants
https://doi.org/10.21508/1027-4065-2016-61-2-50-55
Abstract
Objective: to study the prognostic role of neuron-specific factors, such as brain-derived neurotrophic factor (BDNF), vascular endothelial growth factor (VEGF), and neuron-specific enolase (NSE) in the development of organic central nervous system (CNS) damage in extremely preterm infants at 1-year corrected age. Enzyme immunoassay was used to measure umbilical cord blood at birth, peripheral blood at 7 days of life and at 40 weeks post-conceptual age. It was shown that BDNF was lower and VEGF was higher in the patients who had developed organic brain damage that in those who had transient brain damage (p<0,05). The umbilical cord blood content of NSE in the infants with organic CNS damage exceeded that in those with transient brain damage. There was a close correlation between decreased BDNF, increased VEGF, and the developed organic CNS damage in extremely preterm infants at 1-year corrected age (R = -0,75, R = -0,64).
About the Authors
L. N. Zakharova
Ural Research Institute of Maternal and Infant Care
Russian Federation
Yekaterinburg
Russian Federation
Yekaterinburg
O. A. Kraeva
Ural Research Institute of Maternal and Infant Care
Russian Federation
Yekaterinburg
Russian Federation
Yekaterinburg
G. N. Chistyakova
Ural Research Institute of Maternal and Infant Care
Russian Federation
Yekaterinburg
Russian Federation
Yekaterinburg
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Review
For citations:
Zakharova L.N., Kraeva O.A., Chistyakova G.N. Evaluation of neuron-specific factors in the diagnostics of organic CNS damage in extremely preterm infants. Rossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics). 2016;61(2):50-55. (In Russ.) https://doi.org/10.21508/1027-4065-2016-61-2-50-55
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