Specific features of the lymphocyte enzyme status in newborn infants with the hypotrophic type of intrauterine growth retardation
https://doi.org/10.21508/1027-4065-2016-61-3-46-50
Abstract
Objective: to reveal the specific features of the lymphocyte enzyme status in newborn infants with hypotrophic type of intrauterine growth retardation under the conditions of Yakutia.
Subjects and methods. A total of 137 full-term newborns (including 28 babies with intrauterine growth retardation) whose parents were Yakutsk newcomers were examined on 1, 3 and 5 days of life. The cytochemical activity of lymphocyte enzymes, by determining the level of and time course of changes in succinate dehydrogenase (SDH), glycerol-3-phosphate dehydrogenase (GPDH), lactate dehydrogenase (LDH) and its aerobic isoenzyme (LDH-H), NADFH2-diaphorase, monoamine oxidase (MAO), and acid phosphatase (AP), were analyzed.
Results. It was ascertained that the activity of SDH, GPDH, and LDH was higher on 5 day of life and that of NADFH2-diaphorase was lower in infants with intrauterine growth retardation than in apparently healthy neonates. Desynchronosis of the metabolic pathways was established in the dynamics of early ontogenesis.
Conclusion. It is necessary to rationally correct standard treatment regimens, by taking into account the found metabolic features in infants with intrauterine growth retardation under the conditions of Yakutia.
About the Authors
V. P. Novitskaya
Research Institute for Medical Problems of the North
Russian Federation
Krasnoyarsk
Russian Federation
Krasnoyarsk
V. L. Gritsinskaya
Research Institute for Medical Problems of the North
Russian Federation
Krasnoyarsk
Russian Federation
Krasnoyarsk
References
1. Баранов А.А. Состояние здоровья детей в Российской Федерации. Педиатрия 2012; 91: 3: 9-14. (Baranov A.A. The health status of children in the Russian Federation. Pediatriya 2012; 91: 3: 9–14.)
2. Шабалов Н.П. Задержка внутриутробного роста и развития. Неонатология. М: МЕД пресс-инфо 2009; 1: 88–109. (Shabalov N.P. Intrauterine growth and development. Neonatology. Moscow: MED press-info, 2009; 1: 88–109.)
3. James D.K. High Risk Pregnancy: Management Options (Hardcover). Elsevier Inc, 2006; 9: 8: 590–591.
4. Илатовская Д.В., Логвинова И.И. Гормональный статус новорожденных с задержкой внутриутробного развития. Системный анализ и управление в биомедицинских системах 2010; 9:1: 68–71. (Ilatovskaya D.V., Logvinova I.I. Hormonal status of newborns with intrauterine growth retardation. Sistemnyj analiz i upravlenie v biomedicinskih sistemah 2010; 9:1: 68–71.)
5. Неудахин Е.В. Клинико-метаболические и генетические аспекты гипотрофии у новорожденных и детей раннего возраста. Лекции по педиатрии 2001; 352. (Neudakhin E.V. Clinical and metabolic and genetic aspects of malnutrition in infants and young children. Lectures on Pediatrics 2001; 352.)
6. Петричук С.В., Шищенко В.М., Измайлова Т.Д., Семенова Г.Ф., Писарева И.В., Поляков С.Д., Корнеева И.Т. Диагностические и прогностические возможности клинической цитохимии. Методическое пособие для врачей. М, 2005; 74. (Petrichuk S.V., Shishchenko V.M., Izmajlova T.D., Semenova G.F., Pisareva I.V., Polyakov S.D., Korneeva I.T. Diagnostic and prognostic possibilities of Clinical Сytochemistry. Methodical manual for doctors. Moscow 2005; 74.)
7. Новицкая В.П., Прахин Е.И. Изменение показателей метаболизма лимфоцитов в процессе семимесячной витаминизации у детей. Вопр дет диетол 2011; 9: 6: 49–52. (Novitzkaya V.P., Prakhin E.I. Changes in metabolism of lymphocytes in seven months vitaminisation in children. Vopr det dietol 2011; 9: 6: 49–52.)
8. Усынина А.А., Усынин М.В. Факторы риска перинатальной патологии, состояние здоровья новорожденных детей в условиях Европейского Севера. Экология человека 2001; 1: 43–46. (Usynina A.A., Usynin M. V. Risk factors for perinatal diseases, the health of newborn children in conditions of the European North. Ehkologiya cheloveka 2001; 1: (43–46.)
9. Нарциссов Р.П. Применение n-нитротетразолия фиолетового для количественной цитохимии дегидрогеназ лимфоцитов человека. Арх анат, гистол и эмбриол 1969; 5: 85–91. (Narcissov R. P. Application of n-nitrotetrazolium violet for quantitative cytochemistry dehydrogenases human lymphocytes. Arh anat, gistol ehmbriol 1969; 5: 85–91.)
10. Кондратьева В.П., Эренбург Б.Е. Модификация методики цитохимического выявления моноаминоксидазы. Лаб дело 1981; 3: 167–169. (KondratyevaV.P., ErenburgB.E. Modification method histochemical detection of monoamine oxidase. Lab delo 1981; 3: 167–169.)
11. Goldberg A., Barka Т. Acid phosphatase activity in human blood cell. Nature 1962; 195: 4838.
12. Kaplow L.S. A histochemical procedure for localizing and evaluating leukocyte alkaline phosphatase activity in smears of blood and marrow. Blood 1955; 10: 1023.
13. Сухоруков В.С. Индивидуальные особенности энергообмена и их роль в развитии детских болезней. Рос вестн перинатол и педиатр 2011; 56: 2: 4–11. (Suhorukov V.S. Individual features of energy exchange and their role in the development of childhood diseases. Ros vestn perinatol i pediatr 2011; 56: 2: 4–11.)
14. Неудахин Е.В., Морено И.Г., Гурьева Е.Н. и др. Характер нарушений энергообмена клетки при хроническом стрессе у детей. Рос вестн перинатол и педиатр 2012; 57: 4 (2): 119–125. (Neudakhin E.V., Moreno I.G., Guryeva E.N. et al. Nature of abnormal cell energy metabolism in chronic stress in children. Ros vestn perinatol i pediatr 2012; 57: 4(2): 119–125.)
Review
For citations:
Novitskaya V.P., Gritsinskaya V.L. Specific features of the lymphocyte enzyme status in newborn infants with the hypotrophic type of intrauterine growth retardation. Rossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics). 2016;61(3):46-50. (In Russ.) https://doi.org/10.21508/1027-4065-2016-61-3-46-50
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