Preview

Rossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics)

Advanced search

Clinical and laboratory features and risk factors of perinatal Epstein–Barr virus infection

Abstract

Two hundred and twenty-four mother-neonate pairs were examined; of them 39 infants were diagnosed as having perinatal Epstein– Barr virus infection. Later on, two groups of infants (39 and 98 with and without this infection, respectively) were followed up during the first year of life. Epstein–Barr virus infection was shown to be widespread among fertile-age women and perinatal infection of this etiology. The risk of the perinatal infection is high in the active forms of Epstein–Barr virus infection in women who have complicated pregnancy, in those who are aged over 30 years in particular, in whose who suffer from chronic tonsillitis, who are urban dwellers and have bad habits (smoking). The signs of neonatal perinatal infections are nonspecific manifestations of TORCH syndrome. Acute respiratory viral infections show a complicated course in most cases of infants with perinatal Epstein–Barr virus infection during the first year of life. 

About the Authors

V. B. Kotlova
N.N. Burdenko Voronezh State Medical Academy; Regional Children’s Clinical Hospital Two, Voronezh
Russian Federation


S. P. Kokoreva
N.N. Burdenko Voronezh State Medical Academy; Regional Children’s Clinical Hospital Two, Voronezh
Russian Federation


A. V. Makarova
N.N. Burdenko Voronezh State Medical Academy; Regional Children’s Clinical Hospital Two, Voronezh
Russian Federation


References

1. Сидорова И.С., Макаров И.О., Матвиенко Н.А. Внутриутробная инфекция: ведение беременности, родов и послеродового периода. Учебное пособие. М.: МЕДпрессинформ, 2008; 160. (Sidorova I.S. Makarov I.O., Matvienko N.A. Prenatal infection: conducting pregnancy, childbirth and postnatal period. М: Medpress inform 2008; 160.)

2. Цинзерлинг В. А., Мельникова В.Ф. Перинатальные инфекции (вопросы патогенеза, морфологической диагностики и клинико-морфологических сопоставлений). Руководство для врачей. Ст-Петербург: Сотис 2002; 352. (Tsinzerling V.A., Melnikova V.F. Perinatal infections (questions, morphological diagnostics and klinikomorphological comparisons). The management for doctors. SPb: Sotis 2002; 352.)

3. Лозовская Л.С., Коноплева Т.Н., Шумекая Е.А. и др. Патология матери, плода и ребенка, связанная с вирулентными энтеровирусами, передающимися вертикально. Педиатрия 1998; 4: 11—16. (Lozovsky L.S., Konoplyov T.N., Shumekaya E.A. et al. Pathology of mother, foetus and the child, connected with virulentny enterovirus, being transferred vertically. Pediatrija 1998; 4: 11—16.)

4. Корнюшин М.А., Нисевич Л.П., Талалаев А.Г. и др. Значение различных вирусных инфекций в невынашивании, мертворождении, перинатальной и младенческой смертности. Педиатрия 1999; 1: 4—10. (Kornyushin M. A., Nisevich L.P., Talalayev A.G. et al Value of various virus infections in stillbirth, perinatal and infant mortality. Pediatrija 1999; 1: 4—10.)

5. Сенчук А.Я., Дубоссарская З.М. Перинатальные инфекции. Практическое пособие. М: МИА 2005; 318. (Senchuk A.Y., Dubossarsky Z.M. Perinatal infections. Practical grant. М: MIA 2005; 318.)

6. Kirkham C. Harris S., Grzybowski S. Evidence-based prenatal care: part I. General prenatal care and counseling issues. Am Fam Physician 2005; 71: е 1307—1316.

7. Краснов В.В., Шиленок А.И., Кузенкова Л.А., Кубышева Н.И. Инфекционный мононуклеоз: Клиника, диагностика, современные принципы лечения. Ст-Петербург: Нижний Новгород 2003; 44. (Krasnov V.V., Shilenok A.I., Kuzenkova L.A., Kubysheva N. I. Infectious mononucleosis: Clinic, diagnostics, modern principles of treatment. SPb: Nizhkny Novgorod 2003; 44.)

8. Поляков Б.Е., Лялина В.Н., Воробьева Л.Н. и др. Инфек- ционный мононуклеоз (болезнь Филатова) у детей и подростков. Эпидемиол и инфек бол 1998; 6: 50—54. (Polacov B.E., Lyalina V.N., Vorobyova L.N. et al. Infectious мононуклеоз (Filatov's illness) at children and teenagers. Jepidemiol i infek bol 1998; 6: 50—54.)

9. Кокорева С.П., Куприна Н.П., Котлова В.Б. Инфицированность герпесвирусами дошкольников организованных детских коллективов. Современные технологии в диагностике, лечении и профилактике инфекционных болезней у детей. Сборник науч. работ к 50-летию инфекционного отделения МОНИКИ. М: 2008; 101—104. (Kokoreva S.P., Kuprina N.P., Kotlova V.B. Herpes virus infection in preschool children of the organized children's collectives. Modern technologies in diagnostics, treatment and prevention of infectious diseases in children. Sbornik nauch. rabot k 50-letiju infekcionnogo otdelenija MONIKI. М: 2008; 101—104.)

10. Horwitz C., McClain K, Henle A W. et al. Fatal illness in a 2-week-old infant: diagnosis by detection of Epstein-Barr virus genomes from a lymph node biopsy. J Pediatr 1983; 103: 752—755.

11. Goldberg G.N. In utero Epstein—Barr virus (infectious mononucleosis) infection. JAMA 1981; 246:1579—1581.

12. Марков И.С. Диагностика и лечение герпетических ин- фекций и токсоплазмоза. Киев: АртЭк 2002; 191. (Markov I.S. Diagnostics and treatment of herpetic infections and toxoplasmosis. Кiеv: Artek 2002; 191.)

13. Рогушина Н.Л., Самодова О.В., Титова Л.В. и др. Выяв- ление маркеров краснухи у детей группы риска. Журн инфектол 2010; 2: 4: 15—19. (Rogushina N.L., Samodova O.V., Titova L.V. et al. Identification of markers of a rubella at children of group of risk. Zhurn infektol 2010; 2: 4: 15—19.)


Review

For citations:


Kotlova V.B., Kokoreva S.P., Makarova A.V. Clinical and laboratory features and risk factors of perinatal Epstein–Barr virus infection. Rossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics). 2014;59(1):57-61. (In Russ.)

Views: 660


Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.


ISSN 1027-4065 (Print)
ISSN 2500-2228 (Online)