Features of the complement system in children with chronic urticaria
https://doi.org/10.21508/1027-4065-2016-61-4-98-103
Abstract
To study the specific features of the pathogenesis of urticaria and to clarify the mechanisms maintaining its chronic course, complement
components (C3a, C4, and C1‑inhibitor (C1inh)) were examined in the blood of 50 children with chronic urticaria and 15 healthy children without manifestations of allergy and pseudoallergy. The magnitude of disorders of the complement system was estimated in relation to age, disease duration, and the presence of comorbidity. The serum concentrations of С3а, С4, and С1inh were determined by enzyme immunoassay. Children with an exacerbation of chronic urticaria were established to have elevated C3a and C1inh levels. Decreased C4 levels were associated with autoimmune urticaria and observed in children with a disease duration of more than a year. The levels of C1inh and C4 exhibited a negative paired correlation detected in most children with a positive autoserum test.
About the Authors
N. A. Sinelnikova
Saint Petersburg State Pediatric Medical University, Ministry of Health of Russia;
A. M. Nikiforov All-Russian Center of Emergency and Radiation Medicine, Ministry of Emergency Situations of Russia, Saint Petersburg
Russian Federation
Russian Federation
N. M. Kalinina
Saint Petersburg State Pediatric Medical University, Ministry of Health of Russia;
A. M. Nikiforov All-Russian Center of Emergency and Radiation Medicine, Ministry of Emergency Situations of Russia, Saint Petersburg
Russian Federation
Russian Federation
N. D. Savenkova
Saint Petersburg State Pediatric Medical University, Ministry of Health of Russia;
A. M. Nikiforov All-Russian Center of Emergency and Radiation Medicine, Ministry of Emergency Situations of Russia, Saint Petersburg
Russian Federation
Russian Federation
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Review
For citations:
Sinelnikova N.A., Kalinina N.M., Savenkova N.D. Features of the complement system in children with chronic urticaria. Rossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics). 2016;61(4):98-103. (In Russ.) https://doi.org/10.21508/1027-4065-2016-61-4-98-103
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