Состояние сердечно-сосудистой системы у детей, зачатых при помощи вспомогательных репродуктивных технологий
https://doi.org/10.21508/1027-4065-2016-61-5-14-18
Аннотация
Представлены данные о влиянии особенностей проведения вспомогательных репродуктивных технологий на состояние сердечно-сосудистой системы и метаболизма у детей и взрослых, зачатых с применением указанных технологий. Предполагается, что эпигенетические воздействия могут быть основным механизмом программирования сердечно-сосудистой и метаболической патологии в последующей жизни у таких детей.
Об авторах
Н. В. Башмакова
ФГБУ «Уральский НИИ охраны материнства и младенчества» Минздрава РФ
Россия
д.м.н., проф., засл. врач РФ, директор
Россия
д.м.н., проф., засл. врач РФ, директор
П. Б. Цывьян
ФГБУ «Уральский НИИ охраны материнства и младенчества» Минздрава РФ;
Уральский государственный медицинский университет Минздрава РФ, Екатеринбург
Россия
Россия
отделение биофизических и лучевых методов исследования института
кафедра нормальной физиологии
д.м.н., проф., вед. н. сотр.
зав. кафедрой
620028 Екатеринбург, ул. Репина, д. 1
Г. Н. Чистякова
ФГБУ «Уральский НИИ охраны материнства и младенчества» Минздрава РФ
Россия
Россия
отдел иммунологии и клинической микробиологии
д.м.н., проф., рук. научного отдела
И. В. Данькова
ФГБУ «Уральский НИИ охраны материнства и младенчества» Минздрава РФ
Россия
к.м.н., ст. н. сотрудник
Россия
к.м.н., ст. н. сотрудник
Ю. М. Трапезникова
ФГБУ «Уральский НИИ охраны материнства и младенчества» Минздрава РФ
Россия
к.м.н., н. сотрудник
Россия
к.м.н., н. сотрудник
С. В. Бычкова
ФГБУ «Уральский НИИ охраны материнства и младенчества» Минздрава РФ
Россия
Россия
к.м.н., ст. н. сотрудник
И. И. Ремизова
ФГБУ «Уральский НИИ охраны материнства и младенчества» Минздрава РФ
Россия
Россия
биохимическая лаборатория
к.м.н., ст. н. сотр.
Список литературы
1. Barker D.J. The fetal and infant origins of disease. Eur J Clin Invest 1995; 25: 7: 457–463.
2. Barker D.J. Fetal origins of cardiovascular disease. Ann Med 1999; 31: Suppl 1: 3–6.
3. Barker D.J., Osmond C., Golding J. et al. Growth in utero, blood pressure in childhood and adult life, and mortality from cardiovascular disease. BMJ 1989; 298: 6673: 564–567.
4. Forsen T., Eriksson J., Tuomilehto J. et al. The fetal and childhood growth of persons who develop type 2 diabetes. Ann Intern Med 2000; 133: 1: 176–182.
5. Ludwig A.K., Sutcliffe A.G., Diedrich K. Post-neonatal health and development of children born after assisted reproduction: a systematic review of controlled studies. Eur J Obstet Gynecol Reprod Biol 2006; 127: 1: 3–25.
6. Sunderam S., Kissin D.M., Flowers L. et al. Assisted reproductive technology surveillance — United States, 2009. MMWR Surveill Summ 2012; 61: 1–23.
7. Savage N., Peek J., Hofman P.L., Cutfield W.S. Childhood outcomes of assisted reproductive technology. Human Reprod 2011; 26: 9: 2392–2400.
8. de Mouzon J., Goossens V., Bhattacharya S. et al. Assisted reproductive technology in Europe, 2006: results generated from European registers by ESHRE. Human Reprod 2010; 25: 9: 1851–1862.
9. Charakida M., Deanfield J.E., Halcox J.P. Childhood origins of arterial disease. Curr Opin Pediatr 2007; 19: 5: 538–545.
10. Urbina E.M., Williams R.V., Alpert B.S. et al. Noninvasive assessment of subclinical atherosclerosis in children and adolescents: recommendations for standard assessment for clinical research: a scientific statement from the American Heart Association. Hypertension 2009; 54: 5: 919–950.
11. Laurent S., Cockcroft J., Van Bortel L. et al. Expert consensus document on arterial stiffness: methodological issues and clinical applications. Eur Heart J 2006; 27: 21: 2588–2605.
12. Scherrer U., Rimoldi S.F., Rexhaj E. et al. Systemic and pulmonary vascular dysfunction in children conceived by assisted reproductive technologies. Circulation 2012; 125: 15: 1890– 1896.
13. Ceelen M., van Weissenbruch M.M., Prein J. et al. Growth during infancy and early childhood in relation to blood pressure and body fat measures at age 8–18 years of IVF children and spontaneously conceived controls born to subfertile parents. Hum Reprod 2009; 24: 2788–2795.
14. Ceelen M., van Weissenbruch M.M., Roos J.C. Body composition in children and adolescents born after in vitro fertilization or spontaneous conception. J Clin Endocrinol Metab 2007; 92: 9: 3417–3423.
15. Belva F., Painter R., Bonduelle M. Are ICSI adolescents at risk for increased adiposity? Hum Reprod 2012; 27: 257–264.
16. Yeung E., Druschel C. Cardiometabolic health of children conceived by assisted reproductive technologies. Fertil Steril 2013; 99: 2: 318–326.
17. Miles H.L., Hofman P.L., Peek J. In vitro fertilization improves childhood growth and metabolism. J Clin Endocrinol Metab 2007;92:3441–3445.
18. Sakka S.D., Loutradis D., Kanaka-Gantenbein C. et al. Absence of insulin resistance and low-grade inflammation despite early metabolic syndrome manifestations in children born after in vitro fertilization. Fertil Steril 2010; 94: 1693–1699.
19. Scherrer U., Rimoldi S.F., Rexhaj E. et al. Systemic and pulmonary vascular dysfunction in children conceived by assisted reproductive technologies. Circulation 2012; 125: 1890–1896. 20. Kanaka-Gantenbein C., Sakka S., Chrousos G.P. Assisted reproduction and its neuroendocrine impact on the offspring. Progr Brain Res 2010; 182: 161–174.
20. Bao W., Threefoot S.A., Srinivasan S.R., Berenson G.S. Essential hypertension predicted by tracking of elevated blood pressure from childhood to adulthood: the Bogalusa Heart Study. Am J Hypertens 1995; 8: 657–665.
21. Watkins A.J., Platt D., Papenbrock T. et al. Mouse embryo culture induces changes in postnatal phenotype including raised systolic blood pressure. Proc Natl Acad Sci USA 2007; 104: 5449–5454.
22. Belva F., Henriet S., Liebaers I., Van Steirteghem A. Medical outcome of 8-year-old singleton ICSI children (born >or=32 weeks’ gestation) and a spontaneously conceived comparison group. Hum Reprod 2007; 22: 506–515.
23. Belva F., Roelants M., De Schepper J. et al. Blood pressure in ICSI-conceived adolescents. Hum Reprod 2012; 27: 3100– 3118.
24. Celermajer D.S. Manipulating nature: might there be a cardiovascular price to pay for the miracle of assisted conception? Circulation 2012; 125: 1832–1834.
25. Chason R.J., Csokmay J., Segars J.H. et al. Environmental and epigenetic effects upon preimplantation embryo metabolism and development. Trends Endocrinol Metab 2011; 22: 412–420.
26. Amor D.J., Halliday J. A review of known imprinting syndromes and their association with assisted reproduction technologies. Hum Reprod 2008; 23: 2826–2834.
27. Eroglu A., Layman L.C. Role of ART in imprinting disorders. Semin Reprod Med 2012; 30: 92–104.
28. Klemetti R., Sevon T., Gissler M., Hemminki E. Health of children born after ovulation induction. Fertil Steril 2010; 93: 1157–1168.
29. Ombelet W., Martens G., De Schepper P. et al. Perinatal outcome of 12,021 singleton and 3108 twin births after non-IVFassisted reproduction: a cohort study. Hum Reprod 2006; 21: 1025–1032.
30. Kallen B., Olausson P.O., Nygren K.G. Neonatal outcome in pregnancies from ovarian stimulation. Obstet Gynecol 2002; 100: 414–419.
31. Savage T., Peek J.C., Robinson E.M. et al. Ovarian stimulation leads to shorter stature in childhood. Hum Reprod 2012; 27: 3092–3099.
32. Nelissen E.C., van Montfoort A.P., Coonen E. et al. Further evidence that culture media affect perinatal outcome: findings after transfer of fresh and cryopreserved embryos. Hum Reprod 2012; 27: 1966–1976.
33. Skilton M.R., Evans N., Griffiths K.A., Harmer J.A., Celermajer D.S. Aortic wall thickness in newborns with intrauterine growth restriction. Lancet 2005; 365: 1484–1486.
34. Leeson C.P., Whincup P.H., Cook D.G. et al. Flow-mediated dilation in 9- to 11-year-old children: the influence of intrauterine and childhood factors. Circulation 1997; 96: 2233– 2238.
35. Barker D.J., Bagby S.P., Hanson M.A. Mechanisms of disease: in utero programming in the pathogenesis of hypertension. Nat Clin Pract Nephrol 2006; 2: 700–707.
36. Watkins A.J., Fleming T.P. Blastocyst environment and its influence on off-spring cardiovascular health: the heart of the matter. J Anat 2009; 215: 52–59.
37. Ceelen M., van Weissenbruch M.M., Prein J. et al. Growth during infancy and early childhood in relation to blood pressure and body fat measures at age 8–18 years of IVF children and spontaneously conceived controls born to subfertile parents. Hum Reprod 2009; 24: 2788–2795.
38. Vander-Weele T.J., Mumford S.L., Schisterman E.F. Conditioning on intermediates in perinatal epidemiology. Epidemiology 2012; 23: 1–9.
39. Lewis R., Poore K., Godfrey K. The role of the placenta in the developmental origins of health and disease — implications for practice. Rev Gynaecol Perinat Pract 2006; 6: 70–79
40. Barker D.J., Larsen G., Osmond C., Thornburg K.L. The placental origins of sudden cardiac death. Int J Epidemiol 2012; 41: 1394–1399.
41. Haavaldsen C., Tanbo T., Eskild A. Placental weight in singleton pregnancies with and without assisted reproductive technology: a population study of 536,567 pregnancies. Hum Reprod 2012; 27: 576–582.
42. Bashmakova N.V., Tsyvian P.B., Chistiakova G.N. Endothelial function, regulation of angiogenesis and embryonic central hemodynamics in ART conceived pregnancies. Gynecol Endocrinol 2015; 31: S1: 31–33.
43. Цывьян П.Б., Башмакова Н.В., Проценко Ю.Л. Сократительная активность сердца плода при синдроме задержки развития: связь между региональной неоднородностью, расслаблением и постнагрузкой. Физиология человека 2004; 30: 89–94. (Tsyvian P.B., Bashmakova N.V., Protsenko Yu.L. Contractile cardiac activity in fetuses with intrauterine growth retardation: correlation between regional nonuniformity, relaxation, and afterload. Fiziologiya cheloveka 2004; 30: 89–94. (in Russ))
44. Цывьян П.Б. Внутриутробная гипертензия и ремоделирование сердца плода. Росс физиол журн им. И.М. Сеченова 2004; 90: 8: 457–461. (Tsyvian P.B. Intrauterine hypertension and fetal heart remodeling. Ross fiziol zhurn im I.M. Sechenova 2004; 90: 457–461. (in Russ))
45. Цывьян П.Б., Башмакова Н.В., Михайлова С.В. и др. Ранние гемодинамические изменения у плода при синдроме задержки развития. Рос вестн акуш-гинекол 2006; 5: 12– 15. (Tsyvian P.B., Bashmakova N.V., Mikhailova S.V. et al. Early fetal hemodynamics changes in intrauterine growth restriction. Ros vestn akush-ginekol 2006; 5: 12–15. (in Russ))
46. Tsyvian P.B., Markova T.V., Hop W.C.J., Wladimiroff J.W. Left ventricular isovolumic relaxation and rennin-angiotensin system in the growth restricted fetus. Europ J Obstet Gyn Reprod Biol 2008; 140: 33–37.
47. Tsyvian P.B., Kovtun O.P., Kovalev V.V. Left ventricular isovolumic relaxation time in human embryo: relationship with cardiac afterload in pre- and postnatal hypertension. J Develop Origins Health Disease 2011; 2: Suppl.1: 271.
Рецензия
Для цитирования:
Башмакова Н.В., Цывьян П.Б., Чистякова Г.Н., Данькова И.В., Трапезникова Ю.М., Бычкова С.В., Ремизова И.И. Состояние сердечно-сосудистой системы у детей, зачатых при помощи вспомогательных репродуктивных технологий. Российский вестник перинатологии и педиатрии. 2016;61(5):14-18. https://doi.org/10.21508/1027-4065-2016-61-5-14-18
For citation:
Bashmakova N.V., Tsyvian P.B., Chistyakova G.N., Dankova I.V., Trapeznikova Yu.M., Bychkova S.V., Remizova I.I. The cardiovascular system in children conceived by assisted reproductive technologies. Rossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics). 2016;61(5):14-18. (In Russ.) https://doi.org/10.21508/1027-4065-2016-61-5-14-18
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