Evaluation of the efficiency of antituberculosis vaccination in children born to HIV-infected women
https://doi.org/10.21508/1027-4065-2016-61-5-93-96
Abstract
The key epidemiological indicators were investigated over time forthe bacilli Calmette-Guérin (BCG) (BCG-M) vaccination of HIV-infected children. BCG-induced immunity and vaccination safety were studied in 376 children, including 131 with an established diagnosis of HIV infection, 141 with a perinatal HIV infection contact, and 104 children born to HIV-negative women. There were 60 cases of tuberculosis among the vaccinated. BCG vaccination of children born to HIV-infected women, but to HIV-uninfected ones was ascertained to show a 4-fold decrease in the risk of tuberculosis at an early age and in that of disseminated tuberculosis (including meningitis) (OR= 3.78; p0.05).
BCG vaccination of the HIV-infected children did not reduce the risk of disseminated processes: their proportion among the vaccinated and the unvaccinated was 28.9 and 20.3%, respectively (p>0.05). BCG postvaccination immunity was determined in only one third (29.7%) of the vaccinated in the presence of a small scar in 76.9% of cases.
About the Authors
N. I. Klevno
Research Institute of Phthisiopulmonology, I.M. Sechenov First Moscow State Medical University, Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
T. A. Sevostyanova
Moscow Research and Practical Tuberculosis Control Center, Moscow
Russian Federation
Russian Federation
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Review
For citations:
Klevno N.I., Sevostyanova T.A. Evaluation of the efficiency of antituberculosis vaccination in children born to HIV-infected women. Rossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics). 2016;61(5):93-96. (In Russ.) https://doi.org/10.21508/1027-4065-2016-61-5-93-96
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