Particularly acute intestinal infections in children with atopic dermatitis. Case-control study
https://doi.org/10.21508/1027-4065-2016-61-5-136-140
Abstract
Aim — determine the clinical and laboratory features of acute intestinal infection in children, occurring in conjunction with atopic dermatitis (AD).
Material and methods. We conducted a study of «case-control», which included observation of 144 children hospitalized in the infectious hospital with a clinic of acute infectious diarrhea in the period from January to December 2012. In the study group were selected 72 children with atopic dermatitis clinic and acute infectious diarrhea in a couple of which, from the group of patients without burdened premorbid background were selected 72 «controls» matched by sex, age and etiology developed acute intestinal infection. The observation time was 5±2 days, which corresponds to the average length of stay of the child, patients with moderate forms of acute intestinal infection in the hospital.
Results and discussion. About 2 times more often than in the control, acute intestinal infections in children with atopic dermatitis lesions were characterized by clinic middle and lower gastrointestinal — 31.9% (CI 21,1–42,7) vs. 15.3% (CI 7–23 6), p=0.03. A number of bowel movements 6 or more times per day significantly more frequently observed in children with a combination of acute intestinal infections and atopic dermatitis — 54.1% (CI 42,6–65,6) vs. 33.3% (CI 22,4–43.9) in the control), p=0.011. The duration of diarrhea was higher in the study group (Med 6 IQR 4–7 days and Med 5 IQR 3–6 days, respectively), p=0.046. The proportion of patients with high fever was also higher in the study group than in the controls –15.3% (CI 7–23,6) vs. 2,8% (CI 1–6,6), p=0.016.
Conclusion. Acute intestinal infections in children with atopic dermatitis have a more pronounced clinical symptoms, which is characterized by clinic enterocolitis, severity and duration of diarrhea syndrome, usually accompanied by a high fever.
About the Authors
S. V. Khaliullina
S.V. Kurashov Kazan State Medical University, Ministry of Health of the Russian Federation, Kazan
Russian Federation
Russian Federation
V. A. Anokhin
S.V. Kurashov Kazan State Medical University, Ministry of Health of the Russian Federation, Kazan
Russian Federation
Russian Federation
References
1. Fiocchi A., Pawankar R., Cuello-Garcia C. et al. The World Allergy Organization (WAO) and McMaster University Guidelines for Allergic Disease Prevention (GLAD-P): Probiotics. World Allergy Organization Journal 2015; 8: e4 (doi:10.1186/s40413-015–0055-2).
2. Schneider L., Tilles S., Lio P. et al. Atopic dermatitis: a practice parameter update 2012. J Allergy Clin Immunol 2013; 131: 2: e295–9 (doi: 10.1016/j.jaci.2012.12.672).
3. Баранов А.А., Намазова-Баранова Л.С., Хаитов Р.М. и др. Федеральные клинические рекомендации по оказанию медицинской помощи детям с атопическим дерматитом. http://www.pediatr-russia.ru/sites/default/files/file/ kr_ad.pdf (Baranov A.A., Namazova-Baranova L.S., Haitov R.M. et al. Federal guidelines for the provision of medical pomoschidetyam with atopic dermatitis. http://www.pediatrrussia.ru/sites/default/files/file/kr_ad.pdf (in Russ))
4. Усенко Д.В. Острые кишечные инфекции у детей с атопическим дерматитом: клинико-иммунологические особенности, тактика терапии и реабилитации. Автореф. … докт. мед. наук. М 2013; 44 (Usenko D.V. Acute intestinal infections in children with atopic dermatitis: clinical and immunological features of tactics of therapy and rehabilitation. Avtoref. … d.m.n. Moscow 2013; 44. (in Russ))
5. Takai T. TSLP expression: cellular sources, triggers, and regulatory mechanisms. Allergol Int 2012; 61: 1: е 3–17.
6. Spergel J.M., Beausoleil J.L., Fiedler J.M. et al. Role of allergy in atopic dermatitis (eczema). 2016; http://www.uptodate.com/contents/role-of-allergy-in-atopic-dermatitiseczema?source=see_link
7. Бабкин А.В. Изучение микробно-тканевого комплекса кишечника у больных атопическим дерматитом в различные периоды течения дерматоза. Журн инфектол 2011; 3: 3: е97– 100 (Babkin A.V. The study of microbial-tissue complex bowel in patients with atopic dermatitis in the various periods of flow dermatosis. Zhurn infektol 2011; 3: 3: е97–100. (in Russ))
8. Walker W. Allan Initial Intestinal Colonization in the Human Infant and Immune Homeostasis 2013; 63: 2: е8–15.
9. Макарова С.Г., Болдырева М.Н.,Лаврова Т.Е. и др. Кишечный микробиоценоз, пищевая толерантность и пищевая аллергия. Современное состояние проблемы. Вопр соврем педиатр 2014; 13: 3: е21–29 (Makarova S.G., Boldyreva M.N., Lavrova T.E. et al. Intestinal microbiocenosis, food tolerance and food allergy. The current state of the problem. Vopr sovrem pediatr 2014; 13: 3: е21–29. (in Russ))
10. Guarino A., Ashkenazi S., Gendrel D. et al. European Society for Pediatric Gastroenterology, Hepatology and Nutrition/European Society for Pediatric Infectious Diseases Evidence-Based Guidelines for the Management of Acute Gastroenteritis in Children in Europe: Update 2014. JPGN 2014; 59: е132–152.
11. Meneghin F., Fabiano V., Mameli C. et al. Probiotics and Atopic Dermatitis in Children. Review. Pharmaceuticals 2012; 5: е727–744.
12. Akelma A.Z., Biten A.A. Probiotics and infantile atopic eczema. Pediatric Health Med Therap 2015; 6: е147–151.
13. Rubel D., Thirumoorthy T., Soebaryo R.W. et al. Consensus guidelines for the management of atopic dermatitis: An Asia — Pacific perspective. J Dermatol 2013; 40: е160–171.
Review
For citations:
Khaliullina S.V., Anokhin V.A. Particularly acute intestinal infections in children with atopic dermatitis. Case-control study. Rossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics). 2016;61(5):136-140. (In Russ.) https://doi.org/10.21508/1027-4065-2016-61-5-136-140
Views:
1032
Email this article 