НЕФРОПАТИИ, СВЯЗАННЫЕ С ПАТОЛОГИЕЙ СИСТЕМЫ КОМПЛЕМЕНТА
https://doi.org/10.21508/1027-4065-2016-61-6-21-31
Аннотация
Обобщен научный материал по нефропатиям, связанным с патологией системы комплемента у детей и взрослых. Представлены клинические, иммунологические и морфологические отличия нефропатий, обусловленных патологией системы комплемента, от других заболеваний почек, прежде всего от гломерулонефрита (в том числе мембранопролиферативного варианта) и нефротического синдрома другой природы. Представлен патогенез развития указанных нефропатий, где выделены формы, связанные с генетическими мутациями, и варианты, обусловленные образованием аутоантител к компонентам комплемента. Показаны варианты и эффективность лечения иммуносупрессивными препаратами и экулизумабом в зависимости от патогенетических и клинических особенностей нефропатий, связанных с патологией системы комплемента.
Об авторах
В. В. Длин
ОСП «Научно-исследовательский клинический институт педиатрии имени академика Ю.Е. Вельтищева» ГБОУ ВПО РНИМУ им. Н.И. Пирогова Минздрава России, Москва, Россия
Россия
д.м.н., профессор, руководитель отдела наследственных и приобретенных болезней почек
Россия
д.м.н., профессор, руководитель отдела наследственных и приобретенных болезней почек
М. С. Игнатова
ОСП «Научно-исследовательский клинический институт педиатрии имени академика Ю.Е. Вельтищева» ГБОУ ВПО РНИМУ им. Н.И. Пирогова Минздрава России, Москва, Россия
Россия
заслуженный деятель науки РФ, д.м.н., профессор, научный консультант
Россия
заслуженный деятель науки РФ, д.м.н., профессор, научный консультант
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Рецензия
Для цитирования:
Длин В.В., Игнатова М.С. НЕФРОПАТИИ, СВЯЗАННЫЕ С ПАТОЛОГИЕЙ СИСТЕМЫ КОМПЛЕМЕНТА. Российский вестник перинатологии и педиатрии. 2016;61(6):21-31. https://doi.org/10.21508/1027-4065-2016-61-6-21-31
For citation:
Dlin V.V., Ignatova M.S. NEPHROPATHIES ASSOCIATED WITH COMPLEMENT SYSTEM PATHOLOGY. Rossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics). 2016;61(6):21-31. (In Russ.) https://doi.org/10.21508/1027-4065-2016-61-6-21-31
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