Mitochondrial dysfunction in children with reflux esophagitis
https://doi.org/10.21508/1027-4065-2017-62-2-88-93
Abstract
Objective: to evaluate cellular energy metabolism in children with pathological gastroesophageal reflux, by determining the levels of free and bound carnitine in dry blood spot specimens and lactate and pyruvate in plasma.
Characterization of children and methods. A total of 49 patients from the Diagnostic Department, Republican Children’s Clinical Hospital, Ministry of Health of the Republic of Tatarstan, were examined. A study group included 29 patients diagnosed as having reflux esophagitis. A control group consisted of 20 somatically healthy children without signs of gastrointestinal tract diseases. The investigators determined the levels of lactate and pyruvate in plasma by the Umbreit method and those of free and bound carnitine in the dried blood spot specimens by liquid chromatography-tandem mass spectrometry.
Results. There were significant changes in the lactate-to-pyruvate ratio in children with reflux esophagitis accompanied by motility disorders. The values of free carnitine were higher than normal in 41% of the study group representatives. The mean values of lactate, pyruvate, and carnitines were within the acceptable range in the examined groups with significantly high values in the children with pathological gastroesophageal reflux.
Conclusion. Gastrointestinal tract motility disorders are an indication for the detection of energy-deficient diathesis in children and the early correction with energy-rich medications that will potentially affect the rate of recurrences and the severity of clinical manifestations of the disease.
About the Authors
A. A. Ziganshina
Kazan State Medical University, Ministry of Health of the Russian Federation
Russian Federation
Kazan
Russian Federation
Kazan
V. S. Sukhorukov
Academician Yu.E. Veltishchev Research Clinical Institute of Pediatrics, N.I. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation
Russian Federation
Moscow
Russian Federation
Moscow
V. P. Bulatov
Kazan State Medical University, Ministry of Health of the Russian Federation
Russian Federation
Kazan
Russian Federation
Kazan
References
1. Судаков Н.П., Никифоров С.Б., Невинский Г.А., Константинов Ю.М., Новикова М.А. Роль митохондриальных дисфункций в патогенезе социально-значимых заболеваний. Известия Иркутского государственного университета 2008; 1(2): 11–14. [Sudakov N.P., Nikiforov S.B., Nevinskij G.A., Konstantinov Yu.M., Novikova M.А.. The role of mitochondrial dysfunction in the pathogenesis of socially significant diseases. Izvestija Irkutskogo gosudarstvennogo universiteta 2008; 1(2): 11–14. (in Russ)]
2. Сухоруков В.С. Энергодефицитный диатез у детей. Издание второе. М: ИД «МЕДПРАКТИКА-М» 2012; 28. [Sukhorukov V.S. Energy deficient diathesis in children. Second Edition. Moscow: «MEDPRAKTIKA-M» 2012; 28. (in Russ)]
3. Вербицкий В.И., Чугунова О.Л., Яковлева С.В., Сухоруков В.С., Таболин В.А. Особенности течения, клиники, диагностики и лечения некоторых заболеваний органов мочевой системы у детей раннего возраста. Педиатрия. Журнал им. Г.Н. Сперанского 2002; 81(2): 4–9. [Verbitsky V.I., Chugunova O.L., Yakovleva S.V. Sukhorukov V.S., Tabolin V.А. Some infantile urinary system diseases – peculiarities of their course, clinical presentations, diagnosis and treatment. Pediatriya 2002; 81(2): 4–9 (in Russ)]
4. Нарушение клеточного энергообмена у детей. Под ред. В.С. Сухорукова и Е.А. Николаевой. М: Ates 2004; 79. [Cellular energy exchange imbalance in children. V.S. Sukhorukov, E.A. Nikolaeva (eds). Moscow: Ates 2004; 79. (in Russ)]
5. Накостенко Т.Н., Ключников С.О., Сухоруков В.С. Коррекция нарушений вегетативного гомеостаза и внутриклеточного энергообмена у часто болеющих детей. Вестн педиатр фармакол и нутрициологии 2007; 4(1): 25–29. [Nakostenko T.N., Kljuchnikov S.O., Sukhorukov V.S. Vegetative homeostasis and intracellular energy exchange imbalance correction in frequently ill children. Vestn pediatri farmakol nutriciol 2007; 4(1): 25–29. (in Russ)]
6. Брин И.Л., Неудахин Е.В., Дунайкин М.Л. Карнитин в педиатрии: исследования и клиническая практика. М: ИД «МЕДПРАКТИКА-М» 2015; 112. [Brin I.L., Neudahin E.V., Dunajkin M.L. Carnitine in pediatrics: research and clinical practice. Moscow: «MEDPRAKTIKA-M» 2015; 112. (in Russ)]
7. Зиганшина А.А. Гастроинтестинальные проявления митохондриальной дисфункции. Росс вестн перинатол и педиатр 2016; 61(6): 38–42. DOI:10.21508/1027-4065-2016-61-6-38-42. [Ziganshina A.A. Gastrointestinal manifestations of mitochondrial dysfunction. Rossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics) 2016; 61(6): 38–42. DOI:10.21508/1027-4065-2016-61-6-38-42 (in Russ)]
8. Клембовский А.И. Митохондриальная дисфункция при нефропатиях у детей. II съезд педиатров-нефрологов России. Сб.тез.докл. М 2000; 151–155. [Klembovskij A.I. Mitochondrial dysfunction in children with nephropathy. II congress of pediatrissian nephrologist Rossii. Coll. tezis. Moscow 2000; 151–155. (in Russ)]
9. Николаева Е.А., Харабадзе М.Н., Золкина И.В., Сухоруков В.С., Новиков П.В. Недостаточность карнитина у детей с наследственными болезнями обмена веществ и митохондриальными заболеваниями: особенности патогенеза и эффективность лечения. Педиатрия 2013; 92(3): 42–48. (Nikolaeva E.A., Kharabadze M.N., Zolkina I.V. Sukhorukov V.S, Novikov P.V. Carnitine deficiency in children with inherited metabolic and mitochondrial diseases: features of the pathogenesis and effectiveness of treatment. Pediatrija 2013; 92(3): 42–48. (in Russ)]
10. Сухоруков В.С. Гастроинтестинальные нарушения при полисистемной митохондриальной недостаточности. Росс вестн перинатол и педиатр 2008; 5: 43–47. [Sukhorukov V.S. Gastrointestinal disorders in polysystemic mitochondrial insufficiency. Ross vestn perinatol i pediatr 2008; 5: 43–47 (in Russ)]
11. Бельмер С.В., Гасилина Т.В., Хавкин А.И., Эйберман А.С. Функциональные нарушения органов пищеварения у детей. M: РГМУ 2005; 36. [Bel’mer S.V., Gasilina T.V., Havkin A.I., Jejberman A.S. Functional disorders of the digestive system in children. Moscow: RGMU 2005; 36. (in Russ)]
12. Каламбет Е.И., Османов И.М., Сухоруков В.С., Шабельникова Е.И., Хавкин А.И. Нарушения клеточного энергообмена и их коррекция при заболеваниях органов пищеварения у детей. Вопр практич педиатр 2012; 2: 69–72. [Kalambet E.I., Osmanov I.M., Sukhorukov V.S., Shabel’nikova E.I., Khavkin А.I.. Disorders of cellular energy exchange and their correction in diseases of the digestive system in children. Vopr praktich pediatr 2012; 2: 69–72. (in Russ)]
13. Boles R.G. Combination therapy with co-enzyme Q10, L-carnitine and amitriptyline is highly efficacious in the treatment of cyclic vomiting syndrome and associated functional symptomatology. Rossijskij vestnik perinatologii i pediatrii 2012; 57(4: 2): 105–111.
14. Bain M.A., Milne R.W., Evans A.M. Disposition and metabolite kinetics of oral L-carnitine in humans. J Clin Pharmacol 2006; 46: 10: 1163–1170.
15. Сухоруков В.С. Очерки митохондриальной патологии. М: ИД «МЕДПРАКТИКА-М» 2011; 288. [Sukhorukov V.S. Essays of mitochondrial pathology. Moscow: «MEDPRAKTIKA-M» 2011; 288. (in Russ)]
Review
For citations:
Ziganshina A.A., Sukhorukov V.S., Bulatov V.P. Mitochondrial dysfunction in children with reflux esophagitis. Rossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics). 2017;62(2):88-92. (In Russ.) https://doi.org/10.21508/1027-4065-2017-62-2-88-93
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