PERSONALIZED MEDICINE AS AN UPDATED MODEL OF NATIONAL HEALTH-CARE SYSTEM.PART 1. STRATEGIC ASPECTS OF INFRASTRUCTURE
https://doi.org/10.21508/1027-4065-2017-62-3-7-14
Abstract
The article considers the key problems of the transition of the national health-care system to a new platform of personalized medicine and, in particular, pediatrics. The first part, published in this issue, analyzes the most important of the necessary aspects of the infrastructure of the new model. Evidence is given of the extreme urgency of introducing a new model of predictive, preventive and personalized medicine (PPPM). The result of implementation should be breakthrough success in solving many epidemiological, diagnostic, curative, preventive, social and economic problems. It is emphasized that neonatology and pediatrics are the most important link in this paradigm. When considering the potential architectonics of the model, important characteristics of its main segments are revealed. Diagnostic principles (genotyping, targeting, and dynamic screening of biomarkers) and arsenal (genomics, proteomics, metabolomics, mathematical modeling tools, etc.) of personalized medicine are presented. Attention is focused on the need to create information (global, regional and target-specific) banks that are necessary for monitoring individual health. The need to create a new social decision-making mechanism for selecting a preventive protocol that minimizes the risks of the disease or prevents its development is discussed. Four categories of basic programs of medical and social support of persons from the risk category are considered. The necessary conditions for translating these programs into practice are presented. The main tasks and problems of developing the principles for the preparation of preventive-prophylactic and protocols of medical rehabilitation for personalized medicine were discussed.
About the Authors
S. V. SuchkovRussian Federation
Moscow
H. Abe
Japan
Abe Hiroyuki – MD, PhD,P resident of International Society of Personalized Medicine
Tokyo
E. N. Antonova
Russian Federation
Moscow
P. Barach
United States
Barach Paul – MD, PhD, Clinical Professor, Department of Pediatrics, Wayne State University School of Medicine
Chicago, IL
B. T. Velichkovskiy
Russian Federation
Moscow
M. M. Galagudza
Russian Federation
St. Petersburg
D. A. Dworaczyk
United States
Barach Paul – MD, PhD, Clinical Professor, Department of Pediatrics, Wayne State University School of Medicine
Chicago, IL
D. Dimmock
United States
Dimmock David – MD, PhD, Medical Director, Rady Children’s Hospital, UCSD,
San Diego, CA
V. M. Zemskov
Russian Federation
Moscow
E. Koltunov
Russian Federation
Moscow
R. Lustig
United States
Lustig Robert H. – M.D., PhD, Professor of Pediatrics in the Division of Endocrinology at University of California and Director of the Weight Assessment for Teen and Child Health (WATCH) Program at UCSF
San Francisco
S. I. Malyavskaya
Russian Federation
Arkhangelsk
O. S. Medvedev
Russian Federation
Moscow
E. E. Petryaykina
Russian Federation
Moscow
A. Sh. Revishvili
Russian Federation
Moscow
A. A. Svistunov
Russian Federation
Moscow
D. Smith
United States
Smith David – PhD, Professor, Department of Laboratory Medicine and Pathology and Chairman, Technology Assessment Group, Center for Individualized Medicine, Mayo Clinic
Rochester, MN
V. S. Sukhorukov
Russian Federation
Moscow
A. I. Tyukavin
Russian Federation
St. Petersburg
A. D. Tsaregorodtsev
Russian Federation
N/ Shapira
Israel
Shapira Niva – MD, PhD, Director of Institute for Nutrition Research, Rabin Medical Center, Beilinson Campus, Petah Tikva
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Review
For citations:
Suchkov S.V., Abe H., Antonova E.N., Barach P., Velichkovskiy B.T., Galagudza M.M., Dworaczyk D.A., Dimmock D., Zemskov V.M., Koltunov E., Lustig R., Malyavskaya S.I., Medvedev O.S., Petryaykina E.E., Revishvili A.Sh., Svistunov A.A., Smith D., Sukhorukov V.S., Tyukavin A.I., Tsaregorodtsev A.D., Shapira N. PERSONALIZED MEDICINE AS AN UPDATED MODEL OF NATIONAL HEALTH-CARE SYSTEM.PART 1. STRATEGIC ASPECTS OF INFRASTRUCTURE. Rossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics). 2017;62(3):7-14. (In Russ.) https://doi.org/10.21508/1027-4065-2017-62-3-7-14