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PERSONALIZED MEDICINE AS AN UPDATED MODEL OF NATIONAL HEALTH-CARE SYSTEM.PART 1. STRATEGIC ASPECTS OF INFRASTRUCTURE

https://doi.org/10.21508/1027-4065-2017-62-3-7-14

Abstract

The article considers the key problems of the transition of the national health-care system to a new platform of personalized medicine and, in particular, pediatrics. The first part, published in this issue, analyzes the most important of the necessary aspects of the infrastructure of the new model. Evidence is given of the extreme urgency of introducing a new model of predictive, preventive and personalized medicine (PPPM). The result of implementation should be breakthrough success in solving many epidemiological, diagnostic, curative, preventive, social and economic problems. It is emphasized that neonatology and pediatrics are the most important link in this paradigm. When considering the potential architectonics of the model, important characteristics of its main segments are revealed. Diagnostic principles (genotyping, targeting, and dynamic screening of biomarkers) and arsenal (genomics, proteomics, metabolomics, mathematical modeling tools, etc.) of personalized medicine are presented. Attention is focused on the need to create information (global, regional and target-specific) banks that are necessary for monitoring individual health. The need to create a new social decision-making mechanism for selecting a preventive protocol that minimizes the risks of the disease or prevents its development is discussed. Four categories of basic programs of medical and social support of persons from the risk category are considered. The necessary conditions for translating these programs into practice are presented. The main tasks and problems of developing the principles for the preparation of preventive-prophylactic and protocols of medical rehabilitation for personalized medicine were discussed. 

About the Authors

S. V. Suchkov
I.M. Sechenov First Moscow State Medical University
Russian Federation
Moscow


H. Abe
International Society for Personalized Medicine
Japan

Abe Hiroyuki – MD, PhD,P resident of International Society of Personalized Medicine

Tokyo



E. N. Antonova
I.M. Sechenov First Moscow State Medical University
Russian Federation
Moscow


P. Barach
University of Wayne
United States

Barach Paul – MD, PhD, Clinical Professor, Department of Pediatrics, Wayne State University School of Medicine

Chicago, IL



B. T. Velichkovskiy
N.I. Pirogov Russian National Research Medical University
Russian Federation
Moscow


M. M. Galagudza
North-West Federal Medical Research Center V.A. Almazov
Russian Federation
St. Petersburg


D. A. Dworaczyk
Oracle Corporation
United States

Barach Paul – MD, PhD, Clinical Professor, Department of Pediatrics, Wayne State University School of Medicine

Chicago, IL

 



D. Dimmock
California University
United States

Dimmock David – MD, PhD, Medical Director, Rady Children’s Hospital, UCSD,

San Diego, CA



V. M. Zemskov
A.V. Vishnevskiy Surgery Institute
Russian Federation
Moscow


E. Koltunov
Morozovskaya Pediatric City Clinical Hospital
Russian Federation
Moscow


R. Lustig
California University
United States

Lustig Robert H. – M.D., PhD, Professor of Pediatrics in the Division of Endocrinology at University of California  and Director of the Weight Assessment for Teen and Child Health (WATCH) Program at UCSF

San Francisco



S. I. Malyavskaya
North State Medical University
Russian Federation
Arkhangelsk


O. S. Medvedev
M.V. Lomonosov State University
Russian Federation
Moscow


E. E. Petryaykina
Morozovskaya Pediatric City Clinical Hospital
Russian Federation
Moscow


A. Sh. Revishvili
A.V. Vishnevskiy Surgery Institute
Russian Federation
Moscow


A. A. Svistunov
I.M. Sechenov First Moscow State Medical University
Russian Federation
Moscow


D. Smith
Mayo Clinic
United States

Smith David – PhD, Professor, Department of Laboratory Medicine and Pathology and Chairman, Technology Assessment Group, Center for Individualized Medicine, Mayo Clinic

Rochester, MN



V. S. Sukhorukov
I.M. Sechenov First Moscow State Medical University; N.I. Pirogov Russian National Research Medical University
Russian Federation
Moscow


A. I. Tyukavin
North-West Federal Medical Research Center V.A. Almazov, Ministry of Health of the Russian Federation; St. Petersburg Chemical-Pharmaceutical Academy
Russian Federation
St. Petersburg


A. D. Tsaregorodtsev
N.I. Pirogov Russian National Research Medical University
Russian Federation


N/ Shapira
Ashkelon College
Israel
Shapira Niva – MD, PhD, Director of Institute for Nutrition Research, Rabin Medical Center, Beilinson Campus, Petah Tikva


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For citations:


Suchkov S.V., Abe H., Antonova E.N., Barach P., Velichkovskiy B.T., Galagudza M.M., Dworaczyk D.A., Dimmock D., Zemskov V.M., Koltunov E., Lustig R., Malyavskaya S.I., Medvedev O.S., Petryaykina E.E., Revishvili A.Sh., Svistunov A.A., Smith D., Sukhorukov V.S., Tyukavin A.I., Tsaregorodtsev A.D., Shapira N. PERSONALIZED MEDICINE AS AN UPDATED MODEL OF NATIONAL HEALTH-CARE SYSTEM.PART 1. STRATEGIC ASPECTS OF INFRASTRUCTURE. Rossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics). 2017;62(3):7-14. (In Russ.) https://doi.org/10.21508/1027-4065-2017-62-3-7-14

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ISSN 1027-4065 (Print)
ISSN 2500-2228 (Online)