IMMUNOTHERAPY OF IXODES TICK BORRELIOSIS IN CHILDREN
https://doi.org/10.21508/1027-4065-2017-62-3-121-124
Abstract
The article presents the basic information relating to the clinical and immunological features of ixodes tick-borne borreliosis in children living in the Primorsky region. Research objective: to to analyze the effectiveness of the inclusion to the treatment scheme meglumine acridon acetate (cycloferon in pills) for the treatment of children with ixodes tick-borne borreliosis.
The study included 55 children with ixodes tick-borne borreliosis at the age of 4–12 years: 25 children of the main group and 30 children of the comparison group who received traditional therapy. In the treatment scheme of children of the main group, the drug meglumine acridon acetate (cycloferon) was included. The use of cycloferon in the complex therapy of patients with ixodes tick-borne borreliosis resulted in a reduction in the duration of the manifestation of the main clinical symptoms of the disease, facilitated the synthesis of serum interleukine IL-10 by blood cells and inhibited the production of interleukine-1α and γ-interferon, which led to a faster formation of Th1 / Th2 type Immune response. Positive dynamics during treatment persisted in the study of the catamnesis of the patients observed for 5 years after the disease. There were no cases of chronic ixodes tick-borne borreliosis.
About the Authors
A. A. Chernikova
Pacific State Medical University, Ministry of Health of the Russian Federation
Russian Federation
Vladivostok
Russian Federation
Vladivostok
A. V. Gordeets
Pacific State Medical University, Ministry of Health of the Russian Federation
Russian Federation
Vladivostok
Russian Federation
Vladivostok
S. N. Beniova
Far Eastern Federal University, Ministry of Education and Science of the Russian Federation
Russian Federation
Vladivostok
Russian Federation
Vladivostok
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Review
For citations:
Chernikova A.A., Gordeets A.V., Beniova S.N. IMMUNOTHERAPY OF IXODES TICK BORRELIOSIS IN CHILDREN. Rossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics). 2017;62(3):121-124. (In Russ.) https://doi.org/10.21508/1027-4065-2017-62-3-121-124
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