Clinical case of using discrete plasmapheresis in infant with early neonatal sepsis and hemolytic disease
https://doi.org/10.21508/1027-4065-2017-62-5-49-54
Abstract
Currently in the literature there are insufficient data on the use of efferent hemocorrection methods in neonatal practice. The basic principle of this method is the removal of plasma containing endotoxins and exotoxins and other pathological substances, replacing it with donor plasma, colloid and crystalloid solutions. The therapeutic effect of plasmapheresis includes detoxification, anti-inflammatory and immunomodulatory effects by removing toxins and removal of circulating immune complexes, inflammatory mediators, and activated structures of the complement system. Discrete plasmapheresis in neonatal practice may be used in any body mass of the patient. This article describes a clinical case of successful application of discrete plasmapheresis in full-term newborn baby is in critical condition. The severity was due to severe early neonatal sepsis, development of multiple organ failure and accompanying RH-conflict. After two sessions of plasmapheresis was observed a positive clinical effect in reducing intoxication, systemic inflammatory response syndrome. Reducing the level of bilirubin is allowed to avoid the operation replacement blood transfusion.
About the Authors
S. V. AborinRussian Federation
D. V. Pechkurov
Russian Federation
L. I. Zakharova
Russian Federation
I. V. Katkov
Russian Federation
V. N. Barinov
Russian Federation
References
1. Александрович Ю.С., Пшениснов К.В. Интенсивная терапия новорожденных. Руководство для врачей. СПб: Изд-во Н-Л 2013; 672. [Aleksandrovich Yu.S., Pshenisnov C.V. Intensive care of newborns. A guide for physicians. St Petersburg: Publishing house N-L 2013; 672. (in Russ)]
2. Краснов М.В., Краснов В.М. Сепсис у детей раннего возраста: современные критерии диагноза и принципы лечения. http://pmarchive.ru/sepsis-u-detej-rannego-vozrasta-sovremennye-kriterii-diagnoza-i-principy-lecheniya/ ссылка активна на 08.07.2017. [Krasnov M.V., Krasnov V.M. Sepsis in young children: modern diagnosis criteria and principles of treatment. http://pmarchive.ru/sepsis-udetej-rannego-vozrasta-sovremennye- kriterii-diagnoza-iprincipy-lecheniya/. Link active 08.07.2017. (in Russ)]
3. Клиническая физиология в интенсивной педиатрии. Под ред. А.Н. Шмакова. СПб: Элби СПб, 2014; 384. [Clinical physiology in intensive pediatrics. A.N. Shmakov (ed.). St. Petersburg: ELBI-SPb, 2014; 384. (in Russ)]
4. Данченко С.В., Шмаков А.Н., Лоскутова С.А. Острое почечное повреждение как фактор риска смерти новорожденных детей. Медицина и образование в Сибири 2012; 1: 51. [Danchenko S.V., Shmakov A.N., Loskutova S.A. Acute kidney injury as a risk factor for newborn deaths. Medicina i obrazovanie v Sibiri 2012; 1: 51. (in Russ)]
5. Смирнов А.В., Добронравов В.А., Румянцев А.Ш., Каюков И.Г. Острое повреждение почек. М: Медицинское информационное агентство 2015; 488. [Smirnov A.V., Dobronravov V.A., Rumyantsev A.Sh., Kayukov I.G. Moscow: Medicinskoe informacionnoe agentstvo 2015; 488. (in Russ)]
6. Askenazi D.J., Ambalavanan N., Goldstein S.L. Acute kidney injury in critically ill newborns: what do we know? What do we need to learn? Pediatr Nephrol 2009; 24: 265–274. DOI: 10.1007/s00467-008-1060-2
7. Jetton J.G., Askenazi D.J. Update on acute kidney injury in the neonate. Curr Opin Pediatr 2012; 24: 191–196. DOI: 10.1097/MOP.0b013e32834f62d5
8. Кабаков А.Е., Кусельман А.И., Фисун Е.В., Семенков О.Г. Экстракорпоральная гемокоррекция, эфферентная и заместительная почечная терапия в педиатрической практике. Под ред. А.И. Кусельмана. Изд. 2-е., перераб. и дополненное. Ульяновск: Ульяновский государственный университет 2013; 246. [Kabakov A.E., Kusel’man A.I., Fisun E.V., Semenkov O.G. Extracorporeal haemocorrection, and efferent renal replacement therapy in pediatric patients Ulyanovsk: Ulyanovsk state University 2013; 246. (in Russ)]
Review
For citations:
Aborin S.V., Pechkurov D.V., Zakharova L.I., Katkov I.V., Barinov V.N. Clinical case of using discrete plasmapheresis in infant with early neonatal sepsis and hemolytic disease. Rossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics). 2017;62(5):49-54. (In Russ.) https://doi.org/10.21508/1027-4065-2017-62-5-49-54