Clinical value of indicators of cationic proteins, leukocytes myeloperoxidase and fibronectin blood plasma in viral meningitis in children
https://doi.org/10.21508/1027-4065-2017-62-5-63-68
Abstract
Objective: was to establish clinical and diagnostic value of cytochemical indices of peripheral blood leukocytes (cationic protein and myeloperoxidase), fibronectin blood plasma to assess the severity, predict the course and outcome of viral meningitis in children.
Subjects and methods. In 450 patients with viral meningitis (enterovirus, arbovirus, parotitic, herpesviral, adenovirus etiology) at the age of 14 years, the parameters of the microbicidal system of leukocytes (cation proteins, myeloperoxidase) and fibronectin blood plasma were determined. Etiological diagnosis of meningitis was confirmed by release of viral RNA from blood and cerebrospinal fluid by the polymerase chain reaction, enzyme-linked immunosorbent assay (ELISA).
The results and conclusion. Found that severe, prolonged duration, lethal outcome of viral meningitis in children are accompanied by sugnificant suppression of cationic proteins, myeloperoxidase, fibronectin blood plasma, maximally expressed in lethal outcomes, compared with the severe form, but with a favorable outcome and control. Settings imbalance cationic proteins, myeloperoxidase, fibronectin blood plasma are objective criteria of the adaptation syndrome that reflects the state of the phagocytosis system in viral meningitis in children and can be considered as additional criteria for predicting the course and outcome of disease.
About the Authors
O. G. Kimirilova
Astrakhan state medical University, Ministry оf Health of Russia
Russian Federation
Russian Federation
G. A. Kharchenko
Astrakhan state medical University, Ministry оf Health of Russia
Russian Federation
Russian Federation
References
1. Зиновьева Л.Н., Иванов И.В. Клиническая характеристика серозных менингитов у детей. Инфекционные болезни 2014; 12 (1): 187. [Zinov’eva L.N., Ivanov I.V. Clinical characteristics of serous meningitis in children. Infektsionnye bolezni 2014; 12 (1): 187. (in Russ)]
2. Кимирилова О.Г., Харченко Г.А. Иммуноглобулинотерапия энтеровирусных менингитов у детей. Рос вестн перинатол и педиатр 2016; 61 (2): 79–83. DOI:10.21508/1027-4065-2016-61-2-79-83 [Kimirilova O.G., Kharchenko G.А. Immunoglobulin therapy of enteroviral meningitis in children. Ros vestn perinatol i pediatr 2016; 61 (2): 79–83. (in Russ) DOI:10.21508/1027-4065-2016-61-2-79-83]
3. Кимирилова О. Г., Романцов М.Г., Харченко Г.А. Иммунотропная терапия арбовирусных инфекций у детей. Антибиотики и химиотерапия 2013; 58 (3–4): 44–49. [Kimirilova O. G., Romantsov M.G., Kharchenko G.А. Immunotropic therapy of arbovirus infections in children. Аntibiotiki i khimioterapiya 2013; 58 (3–4): 44–49. (in Russ)]
4. Скрипченко Н.В. Нейроинфекции у детей. Санкт-Петербург: Тактик-Студио 2015; 855. [Skripchenko N.V. Neuroinfections in children. Saint-Petersburg: Taktik-Studio 2015; 855. (in Russ)]
5. Алексеев Н.А. Клинические аспекты лейкопений, нейтропений и функциональных нарушений нейтрофилов. Санкт-Петербург: Фолиант 2002; 416. [Аlekseev N.А. Clinical aspects of leukopenia, and neutropenia functional disorders of neutrophils. Saint- Petersburg: Foliant 2002; 416. (in Russ)]
6. Губжокова Е. Б. Цитохимия катионного белка при острых пневмониях. Фундаментальные исследования 2004; 1: 49. [Gubzhokova E.B. Cytochemistry cationic protein in acute pneumonia. Fundamental’ny issledovaniya 2004; 1:49. (in Russ)]
7. Королева О.И., Петрова Г.К., Шакирова Л.З. Прогностическое значение лизосомальных катионных белков оральных нейтрофилов при острой бронхолегочной патологии у подростков. Вопр соврем педиатр 2006;5:(1):282–283. [Koroleva O.I., Petrova G.K., Shakirova L.Z. Prognostic value of lysosomal cationic proteins in neutrophils of oral acute bronchopulmonary pathology in adolescents. Current pediatrics 2006; 5: 1: 282–283. (in Russ)]
8. Вишневецкая И.Ф., Морозова Ю.В., Карпенко С.Ф. Активность неферментных катионных белков при инфекциях вирусной и риккетсиозной этиологии. Материалы 3 Ежегодного Всероссийского конгресса по инфекционным болезням. 2011 март 28–30. М 2011; 69. [Vishnevetskaya I.F., Morozova Yu.V., Karpenko S.F. Activity-enzymatic cationic proteins with infections of viral and rickettsial etiology. Materials of the 3rd Annual Russian Congress on infectious diseases. 2011 march 28–30. Мoscow 2011; 69. (in Russ)]
9. Молочный В.П., Солодовников О.Н. Микробицидная активность нейтрофильных лейкоцитов крови и цереброспинальной жидкости у детей, больных гнойными и серозными менингитами. Детские инфекции 2012; 11 (4): 16–19. [Molochnyj V.P., Solodovnikov O.N. Microbicidal activity of neutrophils of blood and cerebrospinal fluid in children with purulent and serous meningitis. Detskie infektsii 2012; 11 (4): 16–19. (in Russ)]
10. Горудько И.В., Черкалина О.С., Соколов А.В. Новые подходы к определению концентрации и пероксидазной активности миелопероксидазы в крови человека. Биоорганическая химия 2009; 35 (5): 210. [Gorud’ko I.V., Cherkalina O.S., Sokolov А.V. New approaches to the determination of the concentration and peroxidase activity of myeloperoxidase in human blood. Bioorganicheskaya khimiya 2009; 35 (5): 210. (in Russ)]
11. Arnhold J. Human myeloperoxidase in innate and ackuired immunity. Arch Biochem Biophys 2010; 500 (1): 92–106. DOI.org/10.1201/b16753-6
12. Allen R.C. Myeloperoxidase selectively binds and selective kills microbes. Infect Immunol 2011; 79 (1): 474–485. DOI: 10.1128/IAI.00910-09.
13. Левитан Б.Н., Умерова А.Р., Астахин А.В. Плазменный фибронектин как маркер эндогенной интоксикации при хронических гепатитах и циррозах печени. Кубанский научный медицинский вестник 2009; 109 (4): 116–120. [Levitan B.N., Umerova А.R.. Аstakhin А.V. Plasma fibronectin as a marker of endogenous intoxication in chronic hepatitis and liver cirrhosis. Kubanskij nauchnyj meditsinskij vestnik 2009; 109 (4): 116–120. (in Russ)]
14. Пигаревский В.Е. Зернистые лейкоциты и их свойства. М: Медицина 1978; 33–34. [Pigarevskij V.E. Granular leukocytes and their properties. Moscow: Meditsina 1978; 33–34. (in Russ)]
15. Вишневецкий Ф.Э., Вишневецкая И.Ф., Назарова Е.И. Клиническое значение цитохимического исследования неферментных катионных белков лейкоцитов периферической крови. Клин мед 1981; 11: 88–91. [Vishnevetskij F.E, Vishnevetskaya I.F., Nazarova E.I. Тhe Clinical significance of cytochemical enzymatic cationic proteins of peripheral blood leukocytes. Klin med 1981; 11: 88–91. (in Russ)]
Review
For citations:
Kimirilova O.G., Kharchenko G.A. Clinical value of indicators of cationic proteins, leukocytes myeloperoxidase and fibronectin blood plasma in viral meningitis in children. Rossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics). 2017;62(5):63-68. (In Russ.) https://doi.org/10.21508/1027-4065-2017-62-5-63-68
Views:
1072
Email this article 