Local cytokine profile and cytological status in children with community-acquired pneumonia arising on the background of the reduced resistance of the organism
https://doi.org/10.21508/1027-4065-2017-62-5-139-143
Abstract
Research objective: to study the features of the cytokine profile and cytological status in children with community-acquired pneumonia, proceeding against a background of reduced resistance of the organism for improving treatment methods. 53 children aged 3 to 7 years were examined. The main group consisted of 30 children with community-acquired pneumonia, which ran against a background of reduced resistance of the body. The comparison group consisted of 23 children with community-acquired pneumonia who had good resistance. Local immunity was studied on the basis of valuation of cytokine status parameters (tumor necrotic factor-α, interleukin-8, and interferon-γ) and cellular composition with an estimate of destructive changes in neutrophils in induced sputum. It was revealed that in the main group of children there is a depression of the neutrophils’ release into the bronchial secretion and a marked increase in the number of neutrophils with maximum signs of destruction of the nucleus and cytoplasm against the background of cytokine status imbalance, manifested in an increase in the content of the tumor necrotic factor-α and a decrease in interleukin-8 and interferon- γ. Inclusion in the traditional therapy of community-acquired pneumonia in children who have a reduced resistance, anti-inflammatory drug fenspiride, eliminates the imbalance of proinflammatory cytokines and increases the release of functionally complete neutrophils in the bronchial secret.
About the Authors
T. G. Malanicheva
Kazan State Medical University, Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
S. S. Mozhgina
Children’s Republican Clinical Hospital, Ministry of Health of the Republic of Tatarstan
Russian Federation
Russian Federation
E. V. Agafonova
Kazan State Medical University, Ministry of Health of the Russian Federation
FBUN Kazan Research Institute of Epidemiology and Microbiology of Rospotrebnadzor
Russian Federation
Russian Federation
References
1. Лютина Е.И., Манеров Ф.К. Заболеваемость и смертность от внебольничной пневмонии у детей и подростков, проживающих в Кузбассе. Педиатрия 2015; 94 (2): 203–206. [Lutina E.I., Manerov F.K. Morbidity and mortality from community-acquired pneumonia in children and adolescents living in Kuzbass. Pediatriya 2015; 94(2): 203– 206. (in Russ)]
2. Nair H., Simões E.A., Rudan I., Gessner B.D., Azziz-Baumgartner E., Zhang J.S. et al. Severe Acute Lover Respiratory Infections Working Grop. Global and regional burden of hospital admission for severe acute lower respiratory infection in young children 2010: a systematic analysis. Lancet 2013; 381 (9883): 138013-138090. DOI: 10.1016/S0140-6736(12)61901-1.
3. Paediatric Respiratory Medicine. ERS. E. Eber, F. Midulla (eds). 1st Edition. Handbook: Pediatric Respiratory Medicine, 2013; 719.
4. Внебольничная пневмония у детей. Клинические рекомендации. М: Оригинал-макет 2015; 64. [Communityacquired pneumonia in children. Clinical recommendations. Moscow: Оригинал-макет 2015; 64. (in Russ)]
5. Геппе Н.А., Малахов А.Б., Дронов И.А., Хабибуллина Е.А. Внебольничная пневмония у детей: проблемы диагностики, лечения и профилактики. Доктор. Ру 2015; 13 (114): 28– 30. [Geppe N.A., Malachov A.B., Dronov I.A., Habibullina E.A. Community-acquired pneumonia in children: problems of diagnosis, treatment and prevention. Doctor. RU 2015; 13 (114): 28–30. (in Russ)]
6. Матейко Г.Б., Пылюк И.И. Особенности клиники и факторы риска развития пневмонии у детей, часто болеющих острыми респираторными заболеваниями. Международный журнал прикладных и фундаментальных исследований 2015; 8: 55– 58. [Mateiko G.B., Pylyuk I.I. Features of the clinic and risk factors for the development of pneumonia in children often with acute respiratory diseases. Mezhdunarodnyj zhurnal prikladnykh i fundamental’nykh issledovanij 2015; 8: 55–58. (in Russ)]
7. Галимова Л.Ф., Пикуза О.И., Закирова А.М., Сулейманова З.Я. Особенности цитокинового профиля при внебольничной пневмонии у детей, вызванной атипичными возбудителями. Репродуктивное здоровье детей и подростков 2017; 2: 56–64. [Galimova L.F., Pikuza O.I., Zakirova A.M., Suleymanova Z.Ja. Features of the cytokine profile in community-acquired pneumonia in children, сaused by atypical pathogens. Reproduktivnoe zdorov’e detej i podrostkov 2017; 8: 55–64. (in Russ)]
8. Маланичева Т.Г., Агафонова Е.В., Можгина С.С. Особенности мукозального иммунитета у детей дошкольного возраста с внебольничной пневмонией, протекающей на фоне рекуррентных респираторных заболеваний. Практическая медицина 2016; 7 (99): 68–73. (Malanicheva T.G., Agafonova E.V., Mozhgina S.S. Features of mucosal immunity in preschool children with community-acquired pneumonia, occurring against a background of recurrent respiratory diseases. Prakticheskaya meditsina 2016; 7 (99): 68–73. (in Russ)]
9. Куличков В.И., Мизерницкий Ю.Л., Рыбакова О.Г., Минина Е.Е., Жаков Я.И. Способ получения индуцированной мокроты у детей для оценки степени и характера воспаления слизистой бронхов. №2008116364; 24.04.2008; опубл. 20.08.2009; Бюл. № 23: 10. [Kulichkov V.N., Mizernitsky Yu.L., Rybakova O.G., Minina E.E., Zhakov Ya.I. Method for producing induced sputum in children to assess the extent and nature of inflammation of the bronchial mucosa. №2008116364; 24.04.2008. Published 20.08.2009; Bulletin № 23: 10. (in Russ)]
10. Матвеева Л.А. Местная защита респираторного тракта у детей. Томск: Издательство Томского университета 1993; 276. [Matveeva L.A. Local protection of the respiratory tract in children. Tomsk: Izdatel’stvo Tomskogo universiteta 1993; 276. (in Russ)]
11. Кетлинский С.А., Симбирцев А.С. Цитокины. Санкт-Петербург: ООО «Издательство Фолиант» 2008; 552. [Ketlinsky S.A., Simbirtsev A.S. Cytokines. St. Petersburg: ООО «Izdatel’stvo Foliant» 2008; 552. (in Russ)]
Review
For citations:
Malanicheva T.G., Mozhgina S.S., Agafonova E.V. Local cytokine profile and cytological status in children with community-acquired pneumonia arising on the background of the reduced resistance of the organism. Rossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics). 2017;62(5):139-143. (In Russ.) https://doi.org/10.21508/1027-4065-2017-62-5-139-143
Views:
1092
Email this article 