ЗНАЧЕНИЕ ПОЛИМОРФИЗМА ГЕНА РЕЦЕПТОРА ВИТАМИНА D В ПАТОЛОГИИ ЧЕЛОВЕКА

В обзоре литературы представлены сведения о роли полиморфизма гена рецептора витамина D в патологии человека, поскольку, по современным данным, витамин D представляет собой гормон, который, связываясь со своими специфическими  рецепторами, оказывает многочисленные плейотропные эффекты действия на организм человека. Эти эффекты во многом  могут определять роль витамина D в возникновении и течении ряда широкораспространенных заболеваний современного человека, включая инфекционную патологию, аутоиммунные заболевания, нервно-психические расстройства. Особое  значение в настоящее время придается гену рецептора витамин D VDR, для которого характерен полиморфизм, что может  определять особенности реализации биологических эффектов кальцитриола в организме человека. В статье представлены  обзорные данные, подтверждающие вклад некоторых одиночных нуклеотидных полиморфизмов гена VDR в формирование  плейотропных действий витамина D и их клинических проявлений. 

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