Neurological disorders in children with autism
Abstract
During a clinical examination of children with autistic spectrum disorders, attention should be drawn to both their major clinical manifestations and neurological comorbidities. The paper considers the mechanisms of autism-induced neurological disorders, the spectrum of which may include manifestations, such as retarded and disharmonic early psychomotor development; the specific features of sensory perception/processing; rigidity and monotony of motor and psychic reactions; motor disinhibition and hyperexcitability; motor stereotypies; uncoordinated movements; developmental coordination disorders (dyspraxia); impaired expressive motor skills; speech and articulation disorders; tics; epilepsy. It describes the specific features of neurological symptoms in Asperger’s syndrome, particularly in semantic-pragmatic language disorders, higher incidence rates of hyperlexia, motor and vocal tics. The incidence rate of epilepsy in autistic spectrum disorders is emphasized to be greater than the average population one. At the same time, the risk of epilepsy is higher in mentally retarded patients with autism. Identification of neurological disorders is of great importance in determining the tactics of complex care for patients with autistic spectrum disorders.
About the Authors
N. N. ZavadenkoRussian Federation
N. L. Pechatnikova
Russian Federation
N. V. Semashkova
Russian Federation
A. N. Zavadenko
Russian Federation
K. A. Orlova
Russian Federation
References
1. Симашкова Н.В. Расстройства аутистического спектра. Научно-практическое руководство. М: Авторская Академия 2013; 264. (Simashkova N.V. Autism spectrum disorders. Scientific-practical guide. Moscow: Avtorskaya Academia 2013; 264.)
2. Новоселова О.Г., Каркашадзе Г.А., Журкова Н.В., Маслова О.И. Перспективы диагностики расстройств аутистического спектра у детей. Вопр соврем педиат 2014; 13: 3: 61—68. (Novosyolova O.G., Karkashadze G.A., Zhurkova N.V., Maslova O.I. Prospects of diagnostics of autism spectrum disorders in children. Vopr sovrem pediat 2014; 13: 3: 61—68.)
3. Ньокиктьен Ч. Детская поведенческая неврология. Том 2. М.: Теревинф 2010; 336. (Njiokiktjien Ch. Pediatric behavioural neurology. Vol. 2. Moscow: Terevinf 2010; 336.)
4. Tuchman R.F., Rapin I. Autism: a neurological disorder of early brain development. London: Mac Keith Press 2006; 354.
5. Ming X., Brimacombe M., Wagner G.C. Prevalence of motor impairment in autism spectrum disorders. Brain Dev 2007; 29: 9: 565—570.
6. Горюнова А.В. Неврологические предшественники и маркеры предрасположенности к шизофрении (проспективное исследование детей раннего возраста из группы высокого риска по шизофрении): Автореф. дис. ... д-ра мед. наук. М 1995; 45. (Goriunova A.V. Neurological precursors and markers of schizophrenia predisposition. Prospective study of infants of schizophrenia high risk group: Avtoref. dis. … d-ra med. nauk. Moscow 1995; 45.)
7. Meyer-Lindenberg A. Autismusspektrumstorungen. Der Nervenarzt 2011; 82: 5: 551—552.
8. Rizzolatti G., Luppino G., Matelli M. The organization of the cortical motor system: new concepts. EEG Clin Neurophysiol 1998; 106: 283—296.
9. Rizzolatti G., Fogassi L., Gallese V. Neurophysiological mechanisms underlying action understanding and imitation. Nat Rev Neurosci 2001; 2: 661—670.
10. Iacoboni M. Understanding others: imitation, language, empathy. In: S. Hurley, N. Chater (eds). Perspectives on imitation: from cognitive neuroscience to social science. Cambridge, MA: MIT Press 2005; 77—99.
11. Williams J.H.G., Whiten A., Suddendorf T., Perrett D.I. Imitation, mirror neurons and autism. Neuroscience and Biobehavioural Rev 2001; 25: 287—295.
12. Rizzolatti G., Craighero L. The mirror-neuron system. Annu Rev Neurosci 2004; 27: 169—192.
13. Gillberg C. A Guide to Asperger Syndrome. Cambridge University Press 2002; 190.
14. Gillberg C. Autism and Autistic-like Conditions. In: J. Aicardi. Diseases of the Nervous System in Childhood. 3-rd ed. London: Mac Keith Press 2009; 902—921.
15. Reitzel J., Szatmari P. Cognitive and academic problems. In M. Prior (ed.), Learning and Behaviour Problems in Asperger Syndrome. New York: Guilford Press 2003; 35—55.
16. Mayes S., Calhoun S.L. WISC-IV and WIAT-II profiles in children with high functioning autism. J Autism Dev Disord 2008; 38: 428—439.
17. Hippler K., Klicpera C. A retrospective analysis of the clinical case records of ‘autistic psychopaths’ diagnosed by Hans Asperger and his teach at the University Children’s Hospital, Vienna. In: U. Frith, E. Hill (eds). Autism: Mind and Brain. Oxford: Oxford University Press 2004; 21—42.
18. Attwood T. The Complete Guide to Asperger’s syndrome. Philadelphia, PA: Jessica Kingsley Publishers 2007; 397.
19. Grigorenko E.L., Klin A., Volkmar F. Annotation: Hyperlexia: disability or superability? J Child Psychol Psychiat 2003; 44: 8: 1079—1091.
20. Nation K. Reading Skills in Hyperlexia: A Developmental Perspective. Psychological Bull1999; 125: 3: 338—353.
21. Симашкова Н.В. Атипичный аутизм в детском возрасте: Автореф. дис. … д-ра мед. наук. М 2006; 44. (Simashkova N.V. Atypical autism in childhood: Autoref. dis. … d-ra med. nauk. Moscow 1996; 44.)
22. Гиллберг К., Хеллгрен Л. Психиатрия детского и подросткового возраста. Пер. со швед. М: ГЭОТАР-Мед 2004; 544. (Gillberg C., Hellgren L. Psychiatry of childhood and adolescence. Moscow: GEOTAR-Med 2004; 544.)
23. Amiet C., Gourfinkel-An I., Bouzamondo A. et al. Epilepsy in autism is associated with intellectual disability and gender: evidence from a meta-analysis. Biol Psychiat 2008; 64: 577—582.
24. Tuchman R.F., Rapin I. Regression in pervasive developmental disorders: seizures and epileptiform electroencephalogram correlates. Pediatrics 1997; 99: 560—566.
25. Chez G., Chang M., Krasne V. et al. Frequency of epileptiform EEG abnormalities in a sequential screening of autistic patients with no known clinical epilepsy from 1996 to 2005. Epilepsy Behav 2006; 8: 267—271.
26. Hrdlicka M., Komarek V., Propper L. et al. Not EEG abnormalities but epilepsy is associated with autistic regression and mental functioning in childhood autism. Eur Child Adolesc Psychiat 2004; 13: 209—213.
27. Карлов В.А. Эпилепсия у детей и взрослых женщин и мужчин: Руководство для врачей. М: Медицина 2010; 720. (Karlov V.A. Epilepsy in children and adult women and men. Handbook for physicians. Moscow: Meditsina 2010; 720.)
28. Айкарди Ж., Бакс М., Гиллберг К. Заболевания нервной системы у детей. Пер. с англ. М: Издательство Панфилова, БИНОМ 2013; 1036. (Aicardi J., Bax M., Gillberg C. Diseases of the Nervous System in Childhood. Moscow: Izdatelstvo Panfilova, BINOM 2013; 1036.)
29. Белоусова Е.Д., Ермаков А.Ю. Эпилептическая энцефалопатия с продолженной спайк-волновой активностью во сне: обзор литературы. Журн неврол и психиат 2014; 114: 4: 2: 52—58. (Belousova E.D., Ermakov A.Yu. Epileptic encephalopathy with continuous spikes and waves during sleep (CSWS): a review. Zhurn nevrol i psikhiat 2014; 114: 4: 2: 52—58).
Review
For citations:
Zavadenko N.N., Pechatnikova N.L., Semashkova N.V., Zavadenko A.N., Orlova K.A. Neurological disorders in children with autism. Rossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics). 2015;60(2):14-21. (In Russ.)