ESTIMATION OF THE THICKNESS OF THE INTIMA-MEDIA COMPLEX IN CHILDREN WITH FAMILIAL HYPERCHOLESTEROLEMIA
https://doi.org/10.21508/1027-4065-2018-63-5-152-154
Abstract
Objective: to evaluate the diagnostic significance of measuring the thickness of the intima-media complex (IMC) in children with autosomal dominant familial hypercholesterolemia for early diagnostics and prompt treatment of atherosclerosis.
Materials and methods. The study included 109 children – 64 children with familial hypercholesterolemia and 45 healthy children. Both groups were divided into 2 subgroups according to the age – from 3 to 8 years and from 9 to 18 years. We measured the intimamedia thickness (IMT) of the common carotid artery in all the children. To evaluate IMT we used an ultrasound scanner HD11XE (Philips, USA) with a linear (3–12MHz) sensor IMT.
Results. We found a statistically significant difference (p=0.012) of the IMT of the common carotid artery in children with familial hypercholesterolemia (0.61 ± 0.02 mm) in comparison with the control group (0.49±0.02 mm), starting from the age of 9 years. There were no sex differences of IMT in patients older than 9 years.
Conclusion. We found that children with familial hypercholesterolemia have higher values of IMT already from the age of 9 as compared with healthy children; the increase in TCIM is an additional criterion for the early diagnostics of atherosclerosis and evaluation of cardiovascular risk. These results emphasize the relevance of lipid-lowering therapy for patients with familial hypercholesterolemia in childhood, before the first signs of atherosclerosis appear.
About the Authors
D. I. Sadykova
Kazan State Medical Academy – branch of the Russian Medical Academy of Post-Graduate Education.
Russian Federation
Russian Federation
L. F. Galimova
Children’s Republican Clinical Hospital of Tatarstan Republic.
Russian Federation
Russian Federation
I. V. Leontyeva
Veltischev Research and Clinical Institute for Pediatrics of the Pirogov Russian National Research Medical University.
Russian Federation
Russian Federation
E. S. Slastnikova
Kazan State Medical Academy – branch of the Russian Medical Academy of Post-Graduate Education; Children’s Republican Clinical Hospital of Tatarstan Republic.
Russian Federation
Russian Federation
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Review
For citations:
Sadykova D.I., Galimova L.F., Leontyeva I.V., Slastnikova E.S. ESTIMATION OF THE THICKNESS OF THE INTIMA-MEDIA COMPLEX IN CHILDREN WITH FAMILIAL HYPERCHOLESTEROLEMIA. Rossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics). 2018;63(5):152-154. (In Russ.) https://doi.org/10.21508/1027-4065-2018-63-5-152-154
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