Plasma hemostatic values in infants born at 35-36 weeks' gestation

Abstract

The paper assesses the results of basic coagulation tests and the levels of factors VII, X, VIII, V, and I, protein C, antithrombin III, plasminogen, and D-dimer in babies who were born to mothers with physiological pregnancy and labor at 35—36 weeks' gestation and had no malformations in the early neonatal period. Early (in the first days of fife) hypocoagulation in these babies is shown to be retained during the early neonatal period, as shown by the activated partial thromboplatin time and prothrombin time tests, and to alleviate, as determined by the international normalized ratio. As compared with adults, the examined babies after birth exhibit a reduction mainly in factors VII and X, and, to a lesser extent, factor I; the levels of factors VIII and V did not differ, and there was a decrease in the concentrations of protein С and antithrombin III. Despite having lower plasminogen levels, the newborns are shown to have adequate fibrinolysis in the early neonatal period, which ensures hemostatic stability. The use of the given values will be able to improve the diagnosis of hemostatic disorders and to avoid decision delays in providing adequate care to premature infants.