Dynamics of fecal zonulin values in premature children of the first two weeks of life
https://doi.org/10.21508/1027-4065-2019-64-2-52-56
Abstract
Integrity and permeability of the intestinal barrier in premature children plays an important role digestive disorders and such terrible complications as necrotizing enterocolitis.
Objective. To determine the dynamics of the level of fecal zonulin in premature babies during the first 2 weeks of life and establish the connection between its values and other indicators characterizing the status of extremely premature children.
Materials and methods. There were examined 2 groups of children: Group 1 consisted of 108 premature infants with gestational age of 22–32 weeks and Group 2 (control) included 27 full-term newborns. The level of fecal zonulin was determined by enzyme-linked immunosorbent analysis in dynamics on the 3rd, 7th and 14th days of life.
Results. The premature children have a multiple increase in fecal zonulin levels within 14 days of life compared to healthy full term children. Levels of fecal zonulin on the 7th day of life were significantly higher in children who developed necrotizing enterocolitis on the 10±4.7 days of life.
About the Authors
S. S. Khasanova
Republican Perinatal Center
Uzbekistan
Tashkent
Uzbekistan
Tashkent
A. T. Kamilova
Republican Specialized Scientific and Practical Medical Center of Pediatrics
Uzbekistan
Tashkent
Uzbekistan
Tashkent
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Review
For citations:
Khasanova S.S., Kamilova A.T. Dynamics of fecal zonulin values in premature children of the first two weeks of life. Rossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics). 2019;64(2):52-56. (In Russ.) https://doi.org/10.21508/1027-4065-2019-64-2-52-56
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