The effect of selenium on the immune status in the complex treatment of children with autoimmune thyroiditis
https://doi.org/10.21508/1027-4065-2019-64-2-87-93
Abstract
The authors studied the effect of selenium on the dynamics of immune system indicators in children with autoimmune thyroiditis. They examined 31 children (average age of 11.16 ± 0.59 years). Group I included 17 children who took selenium (100 μg per day for 6 months) along with the basic treatment. Group II (n=14) took L-thyroxin. The control group included 15 healthy children of the same age. The average level of selenium in children of Group I and II was 69.23 ± 1.52 μg / l at the beginning of the study, in the control group it was 114.8 ± 3.18 μg / l. Before treatment, children in Group I and II had T-cell suppression, the average level of all cytokines (especially TNF-α and IL-6) was significantly higher than in practically healthy children.
The study demonstrated that the level of the thyroid tissue antibodies decreased significantly (p=0.001) with an increase in the level of selenium in the blood serum. By the end of the study the content of IgA (p=0.012) and IgG (p=0.044) in Group I, as well as the number of lymphocytes CD3 + (p=0.008), CD4 + (p=0.015), CD16 + / 56 + (p=0.010) significantly increased. The authors observed statistically significant decrease in the levels of TNF-α (p=0.028), IL-6 (p=0.002) and IL-1β (p=0.009) in children who took selenium in addition to the main treatment. Thus, the results of the study suggest that selenium in the complex therapy of autoimmune thyroiditis significantly reduces the titer of antithyroid antibodies and positively affects a number of important indicators of immune homeostasis in children.
About the Authors
G. G. Gabulov
Azerbaidzhan Medical University
Azerbaijan
Baku
Azerbaijan
Baku
G. I. Jabrailova
Azerbaidzhan Medical University
Azerbaijan
Baku
Azerbaijan
Baku
References
1. Bermingham E.N., Hesketh J.E., Sinclair B.R., Koolaard J.P. Selenium-enriched foods are more effective at increasing glutathione peroxidase (GPx) activity compared with selenomethionine: a meta-analysis. Nutrients 2014; 6(10): 4002–4031. DOI: 10.3390/nu6104002
2. Drutel A., Archambeaud F., Caron P. Selenium and the thyroid gland: more good news for clinicians. Clin Endocrinol (Oxf) 2013; 78(2): 155–164. DOI: 10.1111/cen.12066
3. Nourbakhsh M., Ahmadpour F., Chahardoli B. Selenium and its relationship with selenoprotein P and glutathione peroxidase in children and adolescents with Hashimoto’s thyroiditis and hypothyroidism. J Trace Elem Med Biol 2016; 34: 10–14. DOI: 10.1016/j.jtemb.2015.10.003
4. Onal H., Keskindemirci G., Adal E. Effects of selenium supplementation in the early stage of autoimmune thyroiditis in childhood: An open-label pilot study. J Pediatr Endocrinol Metab 2012; 25: 639–644. DOI: 10.1515/jpem-2012-0078
5. Huang Z., Rose A.H., Hoffmann P.R. The Role of Selenium in Inflammation and Immunity: From Molecular Mechanisms to Therapeutic Opportunities. Antioxid Redox Signal 2012; 16(7): 705–743. DOI: 10.1089/ars.2011.4145
6. Gashu D., Marquis G., Bougma K., Stoecker B. Selenium inadequacy hampers thyroid response of young children after iodine repletion. J Trace Elem Med Biol 2018; 50: 291–295. DOI: 10.1016/j.jtemb.2018.07.021
7. Singh K., Chang C., Gershwin M. IgA deficiency and autoimmunity. Autoimmun Rev 2014; 13(2): 163–177. DOI: 10.1016/j.autrev.2013.10.005
8. Zhang Y., Gao Y., Li M., Xie L. Avidity of thyroglobulin antibody in sera from patients with Hashimoto’s thyroiditis with different thyroid functional status. Clin Exp Immunol 2010; 161(1): 65–70. DOI: 10.1111/j.1365-2249.2010.04155.x
9. Toulis K.A., Anastasilakis A.D., Tzellos T.G., Goulis D.G. Selenium supplementation in the treatment of Hashimoto’s thyroiditis: A systematic review and a meta-analysis. Thyroid 2010; 20: 1163–1173. DOI: 10.1089/thy.2009.0351
10. Cogni G., Chiovato L. An overview of the pathogenesis of thyroid autoimmunity. Hormones (Athens) 2013; 12(1): 19–29.
11. Wiersinga W.M. Thyroid autoimmunity. Endocr Dev 2014; 26: 139–157. DOI: 10.1159/000363161
12. Abolhassani H., Gharib B., Shahinpour S., Masoom S.N. Havaei A., Mirminachi B. et al. Autoimmunity in patients with selective IgA deficiency. J Invest Allergol Clin Immunol 2015; 25(2): 112–119.
13. Alfadda A., Benabdelkamel H., Masood A., Jammah A. Differences in the Plasma Proteome of Patients with Hypothy roidism before and after Thyroid Hormone Replacement: A Proteomic Analysis. Int J Mol Sci 2018; 19(1). DOI: 10.3390/ijms19010088
14. De Vito P., Incerpi S., Pedersen J.Z. Thyroid hormones as modulators of immune activities at the cellular level. Thyroid 2011; 21(8): 879–890. DOI: 10.1089/thy.2010.0429.
15. Pascart T., Ducoulombier V., Roquette D., Perimenis P., Coquerelle P., Maury F. et al. Autoimmune thyroid disorders during anti-TNF-alpha therapy: coincidence, paradoxical event or marker of immunogenicity? Joint Bone Spine 2014; 81(4): 369–370. DOI: 10.1016/j.jbspin.2013.11.007
16. Duntas L.H. Selenium and inflammation: underlying antiinflammatory mechanisms. Horm Metab Res 2009; 41(6): 443–447. DOI: 10.1055/s-0029-1220724
17. Hoffmann P.R. Mechanisms by which selenium influences immune responses. Arch Immunol Ther Exp (Warsz) 2007; 55(5): 289–297. DOI: 10.1007/s00005-007-0036-4
18. Krysiak R., Okopien B. The effect of levothyroxine and selenomethionine on lymphocyte and monocyte cytokine release in women with Hashimoto’s thyroiditis. J Clin Endocrinol Metab 2011; 96(7): 2206–2215. DOI: 10.1210/jc.2010-2986
Review
For citations:
Gabulov G.G., Jabrailova G.I. The effect of selenium on the immune status in the complex treatment of children with autoimmune thyroiditis. Rossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics). 2019;64(2):87-93. (In Russ.) https://doi.org/10.21508/1027-4065-2019-64-2-87-93
Views:
1987
Email this article 