Derivatives of acridone acetic acid in pediatric practice
https://doi.org/10.21508/1027-4065-2019-64-2-110-116
Abstract
The article justifies the use of interferon inducers in a clinical practice of pediatrician. The authors isolated a group of derivatives of acridone acetic acid, which effectiveness is associated with the features of pharmacokinetics and pharmacological activity. They demonstrated preventive and therapeutic efficacy of cycloferon in the complex treatment of children with influenza and other acute respiratory viral infections, herpes virus, arbovirus, rotavirus infections, viral hepatitis and tick-borne encephalitis due to its immunomodulatory potency. The article analyzed the use of cycloferon in frequently sick children, patients with allergic diseases, chronic tonsillitis, etc.; also it showed a decrease in the frequency of relapses of both infectious and allergic diseases, the possibility of combined use with other etiotropic and symptomatic drugs.
About the Authors
A. A. Shuldyakov
Razumovsky Saratov State Medical University
Russian Federation
Saratov
Russian Federation
Saratov
E. P. Lyapina
Razumovsky Saratov State Medical University
Russian Federation
Saratov
Russian Federation
Saratov
V. K. Polyakov
Razumovsky Saratov State Medical University
Russian Federation
Saratov
Russian Federation
Saratov
Yu. B. Barylnik
Razumovsky Saratov State Medical University
Russian Federation
Saratov
Russian Federation
Saratov
O. B. Lisko
Razumovsky Saratov State Medical University
Russian Federation
Saratov
Russian Federation
Saratov
N. I. Mishagin
Razumovsky Saratov State Medical University
Russian Federation
Saratov
Russian Federation
Saratov
References
1. Ershov F.I., Kiselev O.I. Interferons and their inductors. Мoscow, 2005; 356 (in Russ)
2. Ershov F.I., Shuldyakov A.A., Romantsov M.G., Lyapyna E.P., Soboleva L.A. Results and Prospects of Interferone Inducers Using in Infectious Diseases Treatment. Vestnik Rossiiskoi akademii meditsinskikh nauk (Bulletin of the Russian Academy of Medical Sciences) 2013; 68; 10: 46–52. (in Russ)
3. Lvov D.K. (ed.). Guide to virology. Viruses and viral infections of humans and animals. Moscow: MIA, 2013; 1200. (in Russ)
4. Malyy V.P., Andreychin M.A. (eds). Gripp and other acute respiratory viral infections. Moscow: GEOTAR-Media, 2012; 320. (in Russ)
5. Shuldyakov A.A., Lyapina E.P., Soboleva L.A., Romantsov M.G., Perminova T.A., Kuznetsov V.I., Narkaitis L.S. The Use of Interferon Inducers in an Infectious Disease Clinic. Аntibiotiki i khimioterapiya (Antibiotics and Chemotherapy) 2018; 63(3–4): 28–36 (in Russ)
6. Antibiotic resistance threats in the United States, 2013: US Department Of Health And Human Services Centers For Disease Control And Prevention. Electronic resource. https://www.cdc.gov/drugresistance/pdf/ar-threats-2013-508.pdf
7. Kawai S., Tomono Y. Acridones as inducers of HL-60 cell differentiation. Leukemia Research 1999; 23: 263–269.
8. Isakov D.V., Isakov V.A. Cycloferon: mechanism of action and new prospects for application in clinical practice. Review clinical medicine 2015; 9: 46–51. PMID: 27008743 (in Russ)
9. Kramer M.J., Cleeland R., Grunberg E. Antiviral activity of 10-carboxymethyl1-9-acridanone. Antimicrob Agents Chemother 1976; 9(2): 233–238.
10. Ershov F.I., Shuldyakov A.A., Romantsov M.G., Ramazanova K.Kh., Shuldyakova O.G. Improving the prevention and treatment of acute respiratory viral infections. Saratovskii nauchno-meditsinskii zhurnal (Saratov J Med Sci Res) 2013; 9(3): 492–495. (in Russ)
11. Kosobytskaya S.A., Zolotareva S.N. Immune prophylaxis of acute respiratory infections in children. Vestnik novykh meditsinskikh tekhnologii (Journal of New Medical Technolo)gies 2016; 3: 189–193. (in Russ)
12. Lysenko I.M., Barkun G.K., Zhuravleva L.N., Fedorishko N.N., Poplavski V.I., Romantsov M.G. Syndrome «frequently and long ill child»: the rehabilitation using cycloferone. Okhrana materinstva i detstva 2016; 1: 53–57 (in Russ)
13. Romantsov M.G., Melnikova I.Yu., Smagina A.N., Shuldyakov A.A. Performance and evaluation of its cycloferon safety resptiratornyh virus infection in children. Fundamental’nye issledovaniya (Fundamental Res) 2012; 2–1: 208–214 (in Russ)
14. Shuldiakov A.A., Liapina E.P., Kuznetsov V.I. Current principles in the chemoprophylaxis of acute respiratory viral infections. Terapevticheskiy arkhiv (Therapeutic archive) 2013; 85(11): 27–33. (in Russ)
15. Teryoshin V.A., Peresadin N.A., Kruglova O.V., Dyachenko T.V. Optimization of pathogenetic therapy in children with tonsillar pathology. Rossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics) 2014; 59(4): 90–95. (in Russ)
16. Kharitonova L.A., Israfilova O.E. Experience of cycloferon therapy in the complex therapy of recurrent respiratory infections in children. Rossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics) 2018; 63(3): 98–104. (in Russ) DOI: 10.21508/1027-4065-2018-63-3-98-104
17. Lyalikov S.A., Bedin P.G., Ermak S. Yu., Yanovich R.V. Effect of cycloferon on tonsils microflora in often ill children. Eksperimental’naya i klinicheskaya farmakologiya 2013; 3: 31–34. (in Russ)
18. Melekhina E.V., Chugunova O.L., Gorelov A.V., Muzyka A.D., Usenko D.V., Karazhas N.V., Kalugina M.Yu., Rybalkina T.N., Boshian R.E. Management tactics for children with persistent cough. Rossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics) 2016; 61(1): 110–120 (in Russ)
19. Vasilenko I.P., Romantsov M.G., Krukov A.I., Grigoryan S.S., Kovalenko A.L. Cycloferon as an Agents of Antirelpsing Therapy in Patients with Chronic Hyperplastic Sinusitis. Аntibiotiki i khimioterapiya (Antibiotics and Chemotherapy) 2013; 7–8: 17–22. (in Russ)
20. Afanasenko K.A., Zhuravleva L.N., Lysenko I.M., Matyushchenko O.V., Poplavsky I.V., Felorishko N.N. The treatment of children with allergic diseases in the outpatient units. Okhrana materinstva i detstva 2015; 2(26): 9–22. (in Russ)
21. Tataurschikova N.S. Interferon inducer cycloferon in the treatment of allergies in immunocompromised patients. Mir farmatsii i meditsiny 2014; 20: 12. (in Russ)
22. Romantsov M.G., Tikhomirova O.V. Correction of Immunity Disorders, Therapy of Intestinal Infections and Disbiosis in Children (Clinical Review). Аntibiotiki i khimioterapiya (Antibiotics and Chemotherapy) 2010; 55; 5–6: 41–49. (in Russ)
23. Novokshonov A.A., Mazankova L.N., Uchaykin V.F. The clinical recommendations concerning diagnostic and treatment of acute intestinal infections in children depending on type of diarrhea. Lechenie i profilaktika 2013; 4(8): 62–73. (in Russ)
24. Vasyutenko E.B., Petrova A.G. Using Meglumine Acridonacetate for the Treatment of Gastroenteritis Caused by Rotavirus in Children. EHksperimental’naya i klinicheskaya farmakologiya 2013; 10: 16–19. (in Russ)
25. Kvetnaya A.S., Bekhtereva M.K., Zhelezova L.I., Kalinogorskaya O.S. The use of cyclopherone in the treatment of salmonella and yersinia infections in children. Аntibiotiki i khimioterapiya (Antibiotics and Chemotherapy) 2012; 57(3–4): 9–16 (in Russ)
26. Yermak S.Yu., Lialikov S.A., Zubritsky M.G., Borodavko O.N. Cycloferon Therapy of Chronic Gastroduodenitis in Children. Аntibiotiki i khimioterapiya (Antibiotics and Chemotherapy) 2014; 7–8: 25–29. (in Russ)
27. Krylova N.V., Leonova G.N. Antiviral activity of various drugs with different mechanisms of action in patients with experimental tick-borne encephalitis. Voprosy virusologii (Problems of Virology) 2016; 61(3): 139–144 (in Russ)
28. Gordeets A.V., Chernikova A.A., Piskunova S.L., Savina O.G. Interferon Inductors in Treatment of Associative Forms of Tick-Borne Infection in Children. Аntibiotiki i khimioterapiya (Antibiotics and Chemotherapy) 2011; 56(11–12): 21–24. (in Russ)
29. Romatsov M.G., Galimzyanov Kh. M., Lokteva O.M., Kovalenko A.L., Stepanov A.V. Experimental and Clinicolaboratory Evaluation of Complex Therapy Efficacy in Arboviral Infections. Аntibiotiki i khimioterapiya (Antibiotics and Chemotherapy) 2012; 57(7–8): 12–22. (in Russ)
30. Kimirilova O.G., Romantsov M.G., Kharchenko G.A. Immunotropic therapy of arbovirus infections in children. Аntibiotiki i khimioterapiya (Antibiotics and Chemotherapy) 2013; 3–4: 44–49. (in Russ)
31. Khamanova Y.B., Sabitov A.U., Fomin V.V., Chesnakova O.A., Ovchinnikova A.O., Lagereva Yu.G. Clinical evaluation of treatment of meningeal form of enteroviral infection by immunomodulators. Ural’skii meditsinskii zhurnal 2013; 6: 50–54 (in Russ)
32. Baranova I.P., Kurmaeva D.Yu. Comparative Analysis of the Effectiveness of Antiviral Therapy of Children with Infectious Mononucleosis. Eksperimental’naya i klinicheskaya farmakologiya 2013; 8: 47–49. (in Russ)
33. Bokovoy A.G., Kovalev I.V., Makkaveeva L.F. Biologycal Imunomodulators in the Complex Therapy of Infectious Mononucleosis in Children. Detskie infektsii 2015; 1: 30–35 (in Russ)
34. Isakov V.A., Isakov D.V. Immunomodulators in the treatment and prevention of herpes virus infections. Klinicheskaya meditsina (Clinical medicine) 2015; 4: 16–24 (in Russ)
35. Kurmaeva D.Yu., Baranova I.P. Therapeutic efficacy of various forms of cycloferone in the treatment of infectious mononucleosis in children. Аntibiotiki i khimioterapiya (Antibiotics and Chemotherapy) 2011; 56(9–10): 33–36. (in Russ)
36. Rasskazova M.E., Rasskazova V.N., Sadova N.G., Simakova A.I. Clinical features of changes of immune deficiency in HIV-infected children in the package of preventive measures. Mezhdunarodnyi zhurnal eksperimental’nogo obrazovaniya 2013; 10–1: 101–104 (in Russ)
37. Khmilevskaya S.A., Zaitseva I.A. Using Interferon Inductors in Therapy of Pre-School-Age Patients with Reactivated Epstein–Barr Virus Infection. Eksperimental’naya i klinicheskaya farmakologiya 2016; 6: 24–29. (in Russ)
38. Vasil’eva D.K., Goryacheva L.G., Monakhova N.E. Features of Immune Response to Etiotropic and Pathogenetic Therapy in Children with Chronic Hepatitis C. Eksperimental’naya i klinicheskaya farmakologiya 2011; 12: 33–35 (in Russ)
39. Dumova S.V. Possibilities of using cycloferon in pediatrics. Praktika pediatra 2017; 4: 3–6. (in Russ)
40. Romantsov M.G., Sologub T.V., Shuldyakov A.A., Bondarenko A.N., Kovalenko A.L. Immunomodulators in Combined Therapy of Patients with Chronic Hepatitis. Аntibiotiki i khimioterapiya (Antibiotics and Chemotherapy) 2011; 56(1–2): 22–28. (in Russ)
41. Sologub T.V., Shuldyakov A.A., Goryacheva L.G. Cycloferon Efficacy of Therapy of Chronic Hepatitis B. Аntibiotiki i khimioterapiya (Antibiotics and Chemotherapy) 2011; 9: 37–41. (in Russ)
42. Evdokimov A.V., Anaschenko A.V., Lyapina E.P., Shuldyakov A.A., Glybochko P.V., Petrenko N.A. Effectiveness of cycloferon in complex treatment of brucellosis patients with lesions of the scrotum. Urologiya 2012; 5: 30–33. (in Russ)
43. Smagina A.N., Shuldyakov A.A. The effect of immunocorrector cycloferon on the quality of life and the psycho-emotional status of patients with chronic active brucellosis on the background of complex pharmacotherapy. Eksperimental’naya i klinicheskaya farmakologiya 2011; 74(2): 39–43. (in Russ)
44. Ivanov A.K., Panteleev A.M., Sukhanov D.S. The use of cycloferon in the complex treatment of tuberculosis patients infected with HIV and viral hepatitis. Clinical medicine 2010; 5: 71–76. (in Russ)
45. Kolomiez V.M., Rubleva N.V., Volf S.B., Demydic S.N. The efficiency of immunomodulators in the treatment of destructive pulmonary tuberculosis. Chelovek i ego zdorov’e (Kursk scientific and practical bulletin) 2013; 1: 81–85. (in Russ)
46. Frolov V.M., Peresadin N.A., Chkhetiany R.B., Kruglova O.V. Increase of Antibacterial Therapy Efficacy in Chronic Sepsis with Cycloferon and Reamberin Combination. Аntibiotiki i khimioterapiya (Antibiotics and Chemotherapy) 2012; 57(5–6): 18–26. (in Russ)
47. Karpenko S.F., Galimzyanov Kh.M., Kasimova N.B., Rubalski O.V., Kraskov A.V., Goryeva O.N. Age aspects of the clinical and immunological manifestations of coxiellosis. Epidemiologiya i infektsionnye bolezni 2012; 6: 16–19. (in Russ)
48. Evgrafov V.D., Isakov V.A., Kovalenko A.L. The use of Cycloferon tablets in the treatment of meningitis. All-Russian scientific-practical conference «New drugs in the prevention of treatment and diagnosis of viral infections». SPb 2002; 149. (in Russ)
49. Kornilov N.N. The main aspects of etiological reasonable complex treatment of degenerative-dystrophic diseases of the knee joint. Vestnik SPbGMА im. I.I. Mechnikova 2003; 4(4): 98–102.9 (in Russ)
50. Sharapova L.E., Shuldyakov A.A., Lyapina E.P. Immunotropic agents in therapy of chronic degenerative diseases of the vulva. Аntibiotiki i khimioterapiya (Antibiotics and Chemotherapy) 2012; 57(3–4): 25–28. (in Russ)
51. Soboleva A.A., Bulkina N.V., Shuldyakov A.A., Pospelov A.N. A new approach in the treatment of inflammatory diseases of the oral cavity. Saratovskii nauchno-meditsinskii zhurnal (Saratov J Med Sci Res) 2013; 9(3): 467–469. (in Russ)
52. Soboleva L.A., Shuldyakov A.A., Bulkina N.V. The topical immunomodulation in the therapy of patient with gingivitis on the backgraund of chronic infectious diseases. Eksperimental’naya i klinicheskaya farmakologiya 2015; 78(7): 41–44. (in Russ)
53. Barkhatova T.S., Shul’dyakov A.A., Gavrilova I.B., Sretenskaya D.A. Using Cycloferon in the Complex Treatment of Herpetic Infection in Patients with Atopic Dermatitis. Eksperimental’naya i klinicheskaya farmakologiya 2014; 77(3): 37–39. (in Russ)
54. Khlamova OG, Shuldyakov A.A., Lepilin A.V. Optimization of herpetic stomatitis therapy in patients with chronic tonsillitis. Аntibiotiki i khimioterapiya (Antibiotics and Chemotherapy) 2011; 56(7–8): 34–36. (in Russ)
55. Shuldyakov A.A., Barkhatova T.S., Zubareva E.V., Satarova S.A., Perminova T.A Topical Immunomodulation in the Treatment of Herpetic Infections in HIV-Infected Patients. Eksperimental’naya i klinicheskaya farmakologiya 2012; 75(11): 35–37. (in Russ)
56. Shuldyakov A.A., Barchatova T.S., Satarova S.A., Perminova T.A. Herpetic infection in patients with psoriasis: the improvement of therapy. Klinicheskaya meditsina (Clinical medicine) 2012; 90(8): 61–63. (in Russ)
57. Cherenov I.V., Galimzyanov Kh.M., Sologub T.V. Estimation of the efficacy of antiviral agents in the treatment of crimean hemorrhagic fever. Klinicheskaya meditsina (Clinical medicine) 2012; 4: 59–62. (in Russ)
58. Sherysheva Yu.V., Galimzyanov Kh.M., Kovalenko A.L. Virus Infections and Interferon Inductors in the Complex Therapy. Аntibiotiki i khimioterapiya (Antibiotics and Chemotherapy) 2012; 1: 26–31. (in Russ)
Review
For citations:
Shuldyakov A.A., Lyapina E.P., Polyakov V.K., Barylnik Yu.B., Lisko O.B., Mishagin N.I. Derivatives of acridone acetic acid in pediatric practice. Rossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics). 2019;64(2):110-116. (In Russ.) https://doi.org/10.21508/1027-4065-2019-64-2-110-116
Views:
940
Email this article 