Topic inhaled antibiotic therapy in children with prolonged adenoiditis
https://doi.org/10.21508/1027-4065-2019-64-3-87-90
Abstract
Currently the issue of antibiotic resistance is urgent due to the unreasonable prescription of systemic antibiotics in the treatment of the upper respiratory tract infections. Frequent use of systemic antibiotic therapy in childhood leads to disruption of the microbiota and the development of secondary immunodeficiency. Alternative topical antibiotic therapy together with mucolytics allows the antibiotic to penetrate directly to the inflammation site and destroy biofilms. The article outlines the use of thiamphenicol glycinate acetylcysteinate in children with prolonged adenoiditis. In Russia this antibiotic is presented by Fluimucil® IT; it is manufactured in the form of a lyophilisate for both injectable solutions and solutions for inhalations and irrigation of mucous membranes. Thiamphenicol glycinate acetylcysteinate helps to improve the course of the disease, in some cases, to avoid invasive procedures and reduce the use of systemic antibiotics.
Keywords
children,
adenoiditis,
prolonged rhinitis,
tubo-otitis,
thiamphenicol glycinate acetylcysteinate,
antibiotic therapy,
inhalation therapy
Supporting agencies: This work was financially supported by Zambon Pharma LLC.
References
1. Гаращенко Т.Н., Кириченко И.М. Синупрет в лечении острого синусита у детей на фоне вирусной инфекции. Медицинский совет 2017; 1: 108–114. [Garashchenko T.N., Kirichenko I.M. Sinupret in the treatment of acute sinusitis in children on the background of a viral infection. Meditsinsky sovet (Medical Council) 2017; 1: 108–114. (in Russ)]
2. Информационное письмо Президента МАКМАХ Романа Сергеевича Козлова о состоянии антимикробной резистентности основных респираторных патогенов в России согласно эпидемиологическим данным МАКМАХ от 24.12.2018. http://www.antibiotic.ru/minzdrav/news/ letter-antimicrobial-resistance-respiratory-pathogens-russia-20181214/ (ccылка активна: 16.04.2019) [Information letter of the President of MACMACh Roman S. Kozlov on the state of antimicrobial resistance of the main respiratory pathogens in Russia according to the epidemiological data of MACMACh (letter from 24 12 2018. (in Russ)]. http://www.antibiotic.ru/ minzdrav/news/letter-antimicrobial-resistance-respiratorypathogens-russia-20181214 (the link is active on 16.04.19).
3. Распоряжение Правительства РФ от 25.09.2017 N 2045-р «Об утверждении Стратегии предупреждения распространения антимикробной резистентности в Российской Федерации» https://www.legalacts.ru/doc/rasporjazhenie-pravitelstva-rf-ot-25092017-n-2045-r-ob-utverzhdenii/ (ccылка активна: 16.04.2019). [Order of the Government of the Russian Federation of September 25, 2017 N 2045-p “On approval of the Strategy for the prevention of the spread of antimicrobial resistance in the Russian Federation” (in Russ)] https://www. legalacts.ru/doc/rasporjazhenie-pravitelstva-rf-ot-25092017-n2045-r-ob-utverzhdenii/ (the link is active on 16.04.19)
4. Комплексный подход к лечению и профилактике острых респираторных инфекций у детей. Практическое руководство для врачей. Под ред. Н.А. Геппе, А.Б. Малахова. М., 2012; 47. [An integrated approach to the treatment and prevention of acute respiratory infections in children. A practical guide for doctors. N.A. Geppe, A.B. Malakhov (eds). Moscow, 2012; 47. (in Russ)]
5. Serra A., Schito G.C., Nicoletti G., Fadda G. A therapeutic approach in the treatmentof infections of the upper airways: thiamphenicol glycinate acetylcysteinate in sequentialtreatment (systemic-inhalatory route). Int J Immunopathol Pharmacol 2007; 20(3): 607–617. DOI: 10.1177/039463200702000319
6. Официальная инструкция по применению Флуимуцилантибиотик-ИТ. Регистрационный номер П №012977/01- 090609, 2018. https://www.rlsnet.ru/mnn_index_id_3230.htm (ccылка активна: 10.10.2018) [Official instructions for use of Fluimucil-antibiotic IT, registration numbe P №012977/01- 090609, 2018. (in Russ)] https://www.rlsnet.ru/mnn_index_ id_3230.htm (the link is active on 10.10.2018)
7. Радциг Е.Ю. Антибактериальные препараты при ЛОРпатологии у детей: показания и пути введения в организм. Педиатрия. Журнал им. Г.Н. Сперанского 2013; 92(1): 111–117. [Radzig E.Yu. Antibacterial drugs for ENT pathology in children: indications and routes of administration in the body. Pediatria 2013; 92(1): 111–117. (in Russ)]
8. Богомильский М.Р., Чистякова В.Р. Детская оториноларингология. М.: ГЭОТАР Медицина, 2001; 431. [Bogomilsky M.R., Chistyakova V.R. Children’s otorhinolaryngology. Moscow: GEOTAR Meditsina, 2001; 431. (in Russ)]
Review
For citations:
Kirichenko I.M. Topic inhaled antibiotic therapy in children with prolonged adenoiditis. Rossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics). 2019;64(3):87-90. (In Russ.) https://doi.org/10.21508/1027-4065-2019-64-3-87-90
Views:
897
Email this article 