Clinical and diagnostic features of pertussis in older children
https://doi.org/10.21508/1027-4065-2019-64-4-70-75
Abstract
В статье представлен анализ клинико-диагностических особенностей коклюша у детей старшего возраста. Удельный вес данной возрастной группы среди госпитализированных составлял 11,3±2,7–13,3±2,7% с преобладанием привитых против этой инфекции больных. У 93,6±3,6% пациентов заболевание протекало в среднетяжелой форме с типичным симптомокомплексом. Для верификации клинического диагноза был использован метод полимеразной цепной реакции (ПЦР) и серологический метод – иммуноферментный анализ (ИФА). Эффективность метода ПЦР составляла 87,8%. Особая диагностическая ценность метода ИФА определялась возможностью подтвердить диагноз коклюша у привитых детей и в поздние сроки болезни, что ранее представляло большие трудности. Основным серологическим критерием служило выявление ассоциации высокого уровня продукции иммуноглобулинов IgG и IgA.
About the Authors
O. P. Popova
Russian Medical Academy of Continuous Professional Education
Russian Federation
Moscow
Russian Federation
Moscow
L. N. Mazankova
Russian Medical Academy of Continuous Professional Education
Russian Federation
Moscow
Russian Federation
Moscow
T. A. Skirda
Gabrichevsky Research Institute for Epidemiology and Microbiology Infectious
Russian Federation
Moscow
Russian Federation
Moscow
S. V. Bunin
Infectious clinical hospital No.1
Russian Federation
Moscow
Russian Federation
Moscow
E. V. Vlasov
Infectious clinical hospital No.1
Russian Federation
Moscow
Russian Federation
Moscow
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Review
For citations:
Popova O.P., Mazankova L.N., Skirda T.A., Bunin S.V., Vlasov E.V. Clinical and diagnostic features of pertussis in older children. Rossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics). 2019;64(4):70-75. (In Russ.) https://doi.org/10.21508/1027-4065-2019-64-4-70-75
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