Diabetes and family hypercholesterolemia in a child: is it real?
L. F. Galimova,
D. I. Sadykova,
I. V. Leontyeva,
E. S. Slastnikova,
M. R. Shaidullina,
N. V. Krinickaya,
A. R. Shakirova,
O. G. Pecheritsa https://doi.org/10.21508/1027-4065-2019-64-4-88-91
Abstract
Diabetes mellitus type 1 is one of the most common chronic diseases among children. It is a pathology of carbohydrate, fat and protein metabolism caused by insulin deficiency in the target tissue. Changes in the lipid profile can be both secondary and primary. The article describes a clinical case of a combination of diabetes mellitus type 1 and family hypercholesterolemia in a child. It presents the clinical and laboratory results of the examination of the child and his parents. Familial hypercholesterolemia is confirmed by mutation of the low density lipoprotein receptor gene (LDLR) in the heterozygous state. In addition, the proband has a polymorphism of the SLCO1B1 gene, which should be considered when prescribing therapy. The demonstrated clinical case shows that familial hypercholesterolemia can be an independent disease, aggravating the course of diabetes mellitus and requiring correction of the therapy.
About the Authors
L. F. Galimova
Republican Children's Hospital
Russian Federation
Kazan
Russian Federation
Kazan
D. I. Sadykova
Kazan State Medical Academy
Russian Federation
Kazan
Russian Federation
Kazan
I. V. Leontyeva
Veltischev Research and Clinical Institute for Pediatrics of the Pirogov Russian National Research Medical University
Russian Federation
Moscow
Russian Federation
Moscow
E. S. Slastnikova
Republican Children's Hospital;
Kazan State Medical Academy
Russian Federation
Kazan
Russian Federation
Kazan
M. R. Shaidullina
Republican Children's Hospital
Russian Federation
Kazan
Russian Federation
Kazan
N. V. Krinickaya
Republican Children's Hospital
Russian Federation
Kazan
Russian Federation
Kazan
A. R. Shakirova
Republican Children's Hospital
Russian Federation
Kazan
Russian Federation
Kazan
O. G. Pecheritsa
Republican Children's Hospital
Russian Federation
Kazan
Russian Federation
Kazan
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For citations:
Galimova L.F., Sadykova D.I., Leontyeva I.V., Slastnikova E.S., Shaidullina M.R., Krinickaya N.V., Shakirova A.R., Pecheritsa O.G. Diabetes and family hypercholesterolemia in a child: is it real? Rossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics). 2019;64(4):88-91. (In Russ.) https://doi.org/10.21508/1027-4065-2019-64-4-88-91
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