Fecal elastase activity in premature children
https://doi.org/10.21508/1027-4065-2019-64-5-44-48
Abstract
We studied the activity of fecal elastase in 54 premature newborns of a gestation period of 22–32 weeks. The samples of feces were collected at the age of 13–14 days. Premature children born at gestational age of 22–28 weeks had pancreatic insufficiency of light degree by 2 weeks of age, preterm infants with a gestational age of 28–32 weeks by 2 weeks of age had the values of pancreatic elastase equal to that of full-term children. The authors have established the relationship between the degree of pancreatic insufficiency and the gestational age of newborns. Fecal elastase activity was significantly lower in premature infants who received milk mixtures as compared to breast-fed infants or infants with mixed feeding. The study substantiated the necessity of early replacement therapy in such newborns to prevent exocrine pancreatic insufficiency.
About the Authors
S. S. Khasanova
Republican Perinatal Center of the Republic of Uzbekistan
Uzbekistan
Tashkent
Uzbekistan
Tashkent
A. T. Kamilova
Republican specialized scientific and practical medical center of pediatrics of the Republic of Uzbekistan
Uzbekistan
Tashkent
Uzbekistan
Tashkent
D. I. Akhmedova
Republican specialized scientific and practical medical center of pediatrics of the Republic of Uzbekistan
Uzbekistan
Tashkent
Uzbekistan
Tashkent
References
1. McClean P., Weaver L.T. Ontogeny of human pancreatic exocrine function. Arch Dis Child 1993; 68: 62–65.
2. Werlin S.L. Development of the exocrine pancreas. In: Pediatric gastrointestinal disease. A.W. Walker, P.R. Durie, J.R. Hamilton (eds). Philadelphia: Mosby, 1996; 143–161.
3. Kori M., Maayan-Metzger A., Shamir R., Sirota L., Dinari G. Faecalelastase 1 levels in premature and full term infants. Arch Dis Child Fetal Neonatal Ed 2003; 88: F106–F108.
4. Vanga R.R., Tansel A., Sidiq S., El-Serag H.B., Othman M.O. Diagnostic Performance of Measurement of Fecal Elastase-1 in Detection of Exocrine Pancreatic Insufficiency: Systematic Review and Meta-analysis. Clin Gastroenterol Hepatol 2018; 16(8): 1220–1228.e4. DOI: 10.1016/j.cgh.2018.01.027
5. Dharmasetiawani N., Firmansyah A. Elastase-1 concentration in feces of term and preterm infants aged 0–4 months. Med J Indones 2003; 12: 69–72.
6. Campeotto F., Kapel N., Kalach N., Raz H. Low levels of pancreatic elastase 1 in stools of preterm Infants. Arch Dis Child Fetal Neonatal Ed 2002; 86: F198–F199.
7. Рылова Н.В. Панкреатическая эластаза в диагностике функциональных и структурных изменений поджелудочной железы у детей. Практическая медицина 2018; 2(113): 66–69. [Rylova N.V. Pancreatic elastase in the diagnosis of functional and structural changes in the pancreas in children. Prakticheskaya meditsina (Practical Medicine) 2018; 2(113): 66–69 (in Russ.)]
8. Struyvenberg M.R., Martin C.R., Freedman S.D. Practical guide to exocrine pancreatic insufficiency – Breaking the myths. BMC Medicine 2017; 15(1): 29. DOI: 10.1186/s12916-017-0783-y
9. Tahtaci M., Koseoglu H., Alisik M., Yurekli O.T., Tahtaci G., Erel O., Ersoy O. Association of Low Fecal Elastase-1 and Non-Ulcer Dyspepsia. J Clin Med 2018; 7(6): 155. DOI: 10.3390/jcm7060155
10. Wali P.D., Loveridge-Lenza B., He Z., Horvath K. Comparison of fecal elastase-1 and pancreatic function testing in children. J Pediatr Gastroenterol Nutr 2012; 54(2): 277–280. DOI: 10.1097/MPG.0b013e31820b0227
11. Münch A., Garten L., Bührer C. Protracted maturation of pancreatic-specific elastase 1 excretion in preterm infants of extremely low gestational age. J Pediatr Gastroenterol Nutr 2013; 56(5): 532–536. DOI: 10.1097/MPG.0b013e-31827fb091
Review
For citations:
Khasanova S.S., Kamilova A.T., Akhmedova D.I. Fecal elastase activity in premature children. Rossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics). 2019;64(5):44-48. (In Russ.) https://doi.org/10.21508/1027-4065-2019-64-5-44-48
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