Time course of changes in proinflammatory cytokines in infants born to women with complicated pregnancy in relation to the course of an early adaptation period
Abstract
Objective: to estimate the time course of changes in proinflammatory cytokines during early neonatal adaptation in infants born to women with complicated pregnancy. The authors examined 57 full-term infants born to women with complicated pregnancy, including 12 babies with the uncomplicated course of an early neonatal period, 24 neonates with the initial manifestations of maladjustment, and 21 infants with the complicated course of an early adaptation period that culminated in perinatal abnormality. A comparison group included 42 babies with the physiological course of an early adaptation period. The umbilical cord and peripheral blood levels of IL-ip, IL-6, and TNF-a were determined by an enzyme immunoassay on 1-3 and 5-7 days of life. The highest umbilical cord blood concentrations of IL-6 and TNF-a were noted in the uncomplicated course of an early neonatal period. At the same time, the level of IL-6 decreased within the first week of fife and that of TNF-a was unchanged. The concentration of IL-ip did not differ from that in the healthy babies. With the initial manifestations of maladjustment, the umbilical cord blood content of IL-ip was comparable with that in the healthy infants, the elevation in the concentrations of IL-6 and TNF-a was less pronounced than that in the neonates with an uncomplicated adaptation period. There was a statistically significantly increase in IL-ip, IL-6, and TNF-a levels in the dynamics of an early neonatal period. Obvious early maladjustment culminating in a disease was accompanied by elevated umbilical cord blood IL-ip and IL-6 levels with no changes in TNF-a. IL-6 hyperproduction persisted as long as 5—7 days of fife; the level of TNF-a significantly increased in the dynamics of an early neonatal period and that of IL-ip decreased at 5—7 days of fife.
About the Authors
G. V. Yakornova
Ural Research Institute of Maternity and Infancy Care, Yekaterinburg
Russian Federation
Russian Federation
I. I. Remizova
Ural Research Institute of Maternity and Infancy Care, Yekaterinburg
Russian Federation
Russian Federation
G. N. Chistyakova
Ural Research Institute of Maternity and Infancy Care, Yekaterinburg
Russian Federation
Russian Federation
L. S. Ustyantseva
Ural Research Institute of Maternity and Infancy Care, Yekaterinburg
Russian Federation
Russian Federation
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Review
For citations:
Yakornova G.V., Remizova I.I., Chistyakova G.N., Ustyantseva L.S. Time course of changes in proinflammatory cytokines in infants born to women with complicated pregnancy in relation to the course of an early adaptation period. Rossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics). 2015;60(4):50-56. (In Russ.)
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