Buy (150 RUB)
Generate QR code
Open Access
Subscription or Fee Access
Overlap syndrome: association of gastroesophageal reflux disease with dyspepsia syndrome in schoolchildren
https://doi.org/10.21508/1027-4065-2022-67-4-54-59
Abstract
The combination of gastroesophageal reflux disease with dyspepsia syndrome in a particular patient is designated as overlap syndrome, the problem of which is widely discussed.
Purpose. To study the regional characteristics of the association of gastroesophageal reflux disease with dyspepsia syndrome in Siberian schoolchildren with gastrointestinal complaints.
Materials and methods. Schoolchildren of Siberia 7–17 years old were examined: in Tyva (1535 children), Buryatia (790 children), and Evenkia (1369 children). Information about gastroenterological complaints was collected. By the method of random selection, children with gastroenterological complaints underwent esophagogastroduodenoscopy in Tyva, 283 children, in Buryatia, 110 children, and in Evenkia, 205 children. The studies were approved by the ethics committee and the consent of the patients and their parents was obtained.
Results. In Siberian schoolchildren, the prevalence of GERD and DS overlap syndrome was 4.7%. In Tyva, the overlap of gastroesophageal reflux disease with dyspepsia syndrome in schoolchildren was found most often: 6.9%, which was significantly higher than in Buryatia (3.7%; p = 0.0016) and in Evenkia (2.8%; p = 0.0001). regional features have been established in the distribution of clinical variants of dyspepsia associated with gastroesophageal reflux disease in schoolchildren. So, in the children of Buryatia and Evenkia, the dominant association was gastroesophageal reflux disease with postprandial distress syndrome, in Tyva — with epigastric pain. Among endoscopically examined schoolchildren in the absence of erosive and ulcerative diseases, similar associative relationships between gastroesophageal reflux disease with dyspepsia syndrome and its clinical variants were determined.
Conclusion. Regional differences were established, both in the prevalence of overlap syndrome and the severity of the association of gastroesophageal reflux disease with variants of the clinical course of dyspepsia syndrome. It is not unlikely that overlapping disorders are united by a single leading pathomechanism in their formation.
About the Authors
T. V. Polivanova
Krasnoyarsk Science Center of the Siberian Branch of the Russian Academy of Sciences
Russian Federation
Russian Federation
Krasnoyarsk
V. A. Vshivkov
Krasnoyarsk Science Center of the Siberian Branch of the Russian Academy of Sciences
Russian Federation
Russian Federation
Krasnoyarsk
References
1. Mousa H., Hassan M. Gastroesophageal Reflux Disease Pediatr Clin North Am 2017; 64(3): 487-505. DOI: 10.1016/j.pcl.2017.01.003
2. Ristic N., Milovanovic I., Radusinovic M., Stevic M., Ristic M., Ristic M. et al. The comparative analyses of different diagnostic approaches in detection of gastroesophageal reflux disease in children. PLoS One 2017; 12(11): e0187081. DOI: 10.1371/journal.pone.0187081
3. Uhlenhopp D.J., Then E.O., Sunkara T., Gaduputi V. Epidemiology of esophageal cancer: update in global trends, etiology and risk factors. Clin J Gastroenterol 2020; 13(6): 1010-1021. DOI: 10.1007/s12328-020-01237-x
4. Vakil N., van Zanten S.V., Kahrilas P., Dent J., Jones R. The Montreal definition and classification of gastroesophageal reflux disease: a global evidence-based consensus. Am J Gastroenterol 2006; 101(8): 1900-1920. DOI: 10.1111/j.1572-0241.2006.00630.x
5. Fass R. Non-erosive reflux disease (NERD) and erosive esophagitis — a spectrum of disease or special entities? Z Gastroenterol 2007; 45(11): 1156-1163. DOI: 10.1055/s-2007-963628
6. Vaezi M.F., Pandolfino J.E., Vela M.F., Shaheen N.J. White Paper AGA: Optimal Strategies to Define and Diagnose Gastroesophageal Reflux Disease. Clin Gastroenterol Hepatol 2017; 15(8): 1162-1172. DOI: 10.1016/j.cgh.2017.03.021
7. Kahrilas P.J., Shaheen N.J., Vaezi M.F. American Gastroenterological Association Institute technical review on the management of gastroesophageal reflux disease. Gastroenterology 2008; 135(4): 1392-1413. DOI: 10.1053/j.gastro.2008.08.044
8. Katz P.O., Gerson L.B., Vela M.F. Guidelines for the diagnosis and management of gastroesophageal reflux disease. Am J Gastroenterol 2013; 108(3): 308-328. DOI: 10.1038/ajg.2012.444
9. Eusebi L.H., Ratnakumaran R., Bazzoli F., Ford A.C. Prevalence of Dyspepsia in Individuals with Gastroesophageal Reflux-Type Symptoms in the Community: A Systematic Review and Meta-analysis. Clin Gastroenterol Hepatol 2018; 16(1): 39-48. DOI: 10.1016/j.cgh.2017.07.041
10. Geeraerts A., Houtte B.V., Clevers E., Geysen H., Vanuytsel T., Tack J. et al. Gastroesophageal Reflux Disease-Functional Dyspepsia Overlap: Do Birds of a Feather Flock Together? Am J Gastroenterol 2020; 115(8): 1167-1182. DOI: 10.14309/ajg.0000000000000619
11. Osadchuk M.A., Osadchuk M.M. Cross functional dyspepsia, gastroesophageal reflux disease and irritable bowel syndrome: optimization of therapy. Russkii meditsinskii zhurnal. Meditsinskoe obozrenie. 2015; 23(28): 1690-1692. (in Russ.)
12. Drossman D.A. Functional Gastrointestinal Disorders: History, Pathophysiology, Clinical Features, and Rome IV. Gastroenterology 2016; 150: 1262-1279. DOI: 10.1053/j.gastro.2016.02.032
13. Polivanova T.V., Pulikov A.S., Vshivkov V.A., Muraviyova N.G. State of collagen fibers in stomach mucosa in schoolchildren with gastroduodenal diseases in Siberial populations. Mezhdunarodnyj zhurnal prikladnykh i fundamental’nykh issledovanii. 2014; 9-2: 82-85. (in Russ.)
14. Richter J.E., Rubenstein J.H. Presentation and Epidemiology of Gastroesophageal Reflux Disease. Gastroenterology 2018; 154(2): 267-276. DOI: 10.1053/j.gastro.2017.07.045
15. Sherman P.M., Hassall E., Fagundes-Neto U., Gold B.D., Kato S., Koletzko S. et al. A Global, Evidence-Based Consensus on the Definition of Gastroesophageal Reflux Disease in the Pediatric Population. Am J Gastroenterol 2009; 104(5): 1278-1295. DOI: 10.1038/ajg.2009.129
16. Belmer S.V., Volynets G.V., Gorelov A.V., Gurova M.M., Zvyagin A.A., Kornienko E.A. et al. Functional digestive disorders in children. Guidelines of the Society of Pediatric Gastroenterologists, Hepatologists and Nutritionists. Part 2. Rossiyskiy Vestnik Perinatologii i Pediatrii 2020; 65(5): 100-111. (in Russ.). DOI: 10.21508/1027-4065-2020-65-5-100-111
17. Pechkurov D.V., Gorelov A.V. Dyspepsia syndrome in children: differential diagnosis, differentiated approach to treatment. Russkii Meditsinskii Zhurnal 2012; 20(24): 1228-1232. (in Russ.)
Review
For citations:
Polivanova T.V., Vshivkov V.A. Overlap syndrome: association of gastroesophageal reflux disease with dyspepsia syndrome in schoolchildren. Rossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics). 2022;67(4):54-59. (In Russ.) https://doi.org/10.21508/1027-4065-2022-67-4-54-59
Views:
411
Email this article 