Clinical and morphological characteristics of malformations in infants with congenital cytomegalovirus infection and congenital toxoplasmosis
Abstract
The results of following up infants with intrauterine infections and malformations were retrospectively analyzed. Infants with malformations were diagnosed as having congenital cytomegalovirus infection and congenital toxoplasmosis in 127 and 69 cases, respectively. The aim of the study was to characterize malformations in infants with congenital cytomegalovirus and congenital Toxoplasma infections. The infants with malformations in congenital cytomegalovirus infection were found to have higher mortality rates (61,4%) than those with congenital toxoplasmosis (34,8%). Postmortem analysis indicated that there was a predominance of embryopathies in infants with congenital cytomegalovirus infection and that of fetopathies in those with congenital toxoplasmosis. The dead infants with congenital cytomegalovirus infection had more commonly developed visceral defects, including heart diseases, pneumopathies, gastrointestinal and genitourinary abnormalities; fetopathies of the central nervous system and eye were prevalent in congenital toxoplasmosis. The surviving children with congenital toxoplasmosis were more frequently observed to have disabling CNS and ocular sequels as obstructive hydrocephalus, infantile cerebral palsy, complete or partial blindness, and cerebrasthenic disorders than those with congenital cytomegalovirus infection.
About the Authors
L. Yu. Barycheva
Stavropol State Medical University
Russian Federation
Russian Federation
M. V. Golubeva
Stavropol State Medical University
Russian Federation
Russian Federation
M. A. Kabulova
Stavropol State Medical University
Russian Federation
Russian Federation
I. V. Kostornaya
Stavropol State Medical University
Russian Federation
Russian Federation
References
1. Гудинова Ж.В. Научные основы социально-гигиенического мониторинга инвалидности детей: Автореф. дисс. … д-ра мед. наук. Омск 2005; 52. (Gudinova Zh.V. Scientific bases of social and hygienic monitoring of disability of children: Avtoref. dis. … dr. med. sci. Omsk 2005; 52.)
2. Лобзин Ю.В., Васильев В.В., Скрипченко Н.В. и др. Актуальные аспекты врожденных инфекций в России. Журн инфектол 2010; 2; 2: 14–24. (Lobzin Yu.V., Vasil’ev V.V., Skripchenko N.V. et. al. Actual aspects of congenital infections in Russia. Zhurnal infektologii 2010; 2; 2: 14–24.)
3. Zheng I.Y., Zhang T., Wang Y.F. et al. Intrauterine Infections and Birth Defects. Biomedical and environmental sciences 2004; 17: 476–491.
4. Ornoy A., Diav-Citrin O. Fetal effects of primary and secondary cytomegalovirus infection in pregnancy. Reprod Toxicol 2006; 21: 399–409.
5. Cheeran M.C.J., Lokensgard J.R., Schleiss M.R. Neuropathogenesis of Congenital Cytomegalovirus Infection: Disease Mechanisms and Prospects for Intervention. Clin Microbiol Rev 2009; 22: 99–126.
6. Pascual-Castroviejo I., Pascual-Pascual S.I., Velazquez-Fragua R. et al. Congenital cytomegalovirus infection and cortical/ subcortical malformations. Neurologia 2012; 27: 336–342.
7. Голубева М.В., Барычева Л.Ю., Огузова Э.Ю. Роль врожденной цитомегаловирусной инфекции в нарушении механизмов иммунной адаптации. Медицинский вестник северного Кавказа 2008; 3: 11: 15–19. (Golubeva M.V., Barycheva L.Yu., Oguzova E.Yu. Role of a congenital tsitomegalovirusny infection in violation of mechanisms of immune adaptation. Meditsinskiy vestnik Severnogo Kavkaza 2008; 3: 15–19.)
8. Орехов К.В., Барычева Л.Ю. Формирование системы иммунитета у детей с врожденными инфекциями. Ставрополь, 2006; 130. (Orehov K.V., Barycheva L.Yu. Formation of system of immunity at children with congenital infections. Stavropol, 2006; 130.)
9. Shen C., Zheng S., Wang W. et al. Relationship between prognosis of biliary atresia and infection of cytomegalovirus. World J Pediat 2008; 2: 123–126.
10. Peyron F., Garweg J.G., Wallon M. et al. Long-term impact of treated congenital toxoplasmosis on quality of life and visual performance. Pediat Infect Dis J 2011; 30: 7: 597–600.
11. McLeod R., Khan A.R., Noble G.A. et al. Why prevent, diagnose and treat congenital toxoplasmosis? Mem Inst Oswaldo Cruz 2009; 104: 2: 320–344.
12. Барычева Л.Ю. Клинические и иммунологические особенности врожденного токсоплазмоза. Рос вестн перинатол и педиат 2004; 49: 2: 55–59. (Barycheva L.Yu. Clinical and immunological features of congenital toxoplasmosis. Ros vestn perinatol i pediatr 2004; 49: 2: 55–59.)
13. Барычева Л.Ю., Голубева М.В., Кабулова М.А. Пороки развития у детей с врожденной цитомегаловирусной и токсоплазменной инфекциями. Современные проблемы науки и образования 2014; 1. http://www.scienceeducation. ru/115–12100. (Barycheva L.Yu., Golubeva M.V., Kabulova M.A. Malformations in children with congenital Cytomegalovirus infections and congenital toxoplasmosis. Sovremennye problemy nauki i obrazovaniya 2014; 1. http:// www.science-education.ru/115–12100)
Review
For citations:
Barycheva L.Yu., Golubeva M.V., Kabulova M.A., Kostornaya I.V. Clinical and morphological characteristics of malformations in infants with congenital cytomegalovirus infection and congenital toxoplasmosis. Rossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics). 2015;60(3):50-57. (In Russ.)
Views:
815
Email this article 