Митохондриальная динамика и значение ее нарушений в развитии детских болезней. Часть II. Кардиологические и эндокринологические аспекты

Динамика митохондриальных преобразований в клетке вызывает в последние годы все больший интерес как представителей фундаментальной науки, так и исследователей в области прикладной медицины. Растет число наблюдений, доказывающих важное регуляторное влияние митохондриальной динамики на разнообразные физиологические и патологические процессы во многих, если не во всех органных и тканевых структурах. Представляются все более значимыми перспективы изучения особенностей и регуляторов этих процессов для понимания патогенеза заболеваний, разработки их новых биомаркеров, а также технологий лечения. Цель настоящей статьи — обзор полученных в отношении митохондриальной динамики фактов, которые, с точки зрения авторов, заслуживают внимания педиатров. Объем соответствующей информации оказался слишком широк, чтобы уместиться в рамках одной статьи, что заставило разделить ее на несколько последовательных публикаций. Во второй части приведены сведения о роли нарушений митохондриальной динамики в патогенезе сердечно-сосудистых и эндокринных заболеваний у детей.

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