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Familial Mediterranean fever in children
T. S. Kurina,
V. A. Mironova,
M. I. Dubrovskaya,
H. A. Sarkisyan,
N. V. Davidenko,
T. V. Zubova,
V. G. Shatalov https://doi.org/10.21508/1027-4065-2025-70-1-88-95
Abstract
Familial Mediterranean fever (periodic disease) is the most common disease from the group of hereditary periodic fevers, which is caused by a mutation in the MEFV gene and is inherited in an autosomal recessive manner. Familial Mediterranean fever is most common among representatives of certain ethnic groups — Armenians, Turks, Sephardic Jews — in these populations, the incidence of Familial Mediterranean fever reaches 1:500. The clinical picture is characterized by periodic attacks of fever combined with abdominalgia, relieved within 12–72 hours. Aseptic inflammation of the serous membranes causes peritonitis, synovitis, pleurisy. Surgery for periodic disease can lead to the development of adhesive disease, and as a consequence — intestinal obstruction. The article presents clinical cases of periodic disease in children who received and or not receive colchicine therapy, including those with colchicine resistance.
About the Authors
T. S. Kurina
Pirogov Russian National Research Medical University
Russian Federation
Russian Federation
Moscow
V. A. Mironova
Pirogov Russian National Research Medical University
Russian Federation
Russian Federation
Moscow
M. I. Dubrovskaya
Pirogov Russian National Research Medical University
Russian Federation
Russian Federation
Moscow
H. A. Sarkisyan
Pirogov Russian National Research Medical University; Speransky Children’s City Clinical Hospital No. 9
Russian Federation
Russian Federation
Moscow
N. V. Davidenko
Speransky Children’s City Clinical Hospital No. 9
Russian Federation
Russian Federation
Moscow
T. V. Zubova
Speransky Children’s City Clinical Hospital No. 9
Russian Federation
Russian Federation
Moscow
V. G. Shatalov
Speransky Children’s City Clinical Hospital No. 9
Russian Federation
Russian Federation
Moscow
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Review
For citations:
Kurina T.S., Mironova V.A., Dubrovskaya M.I., Sarkisyan H.A., Davidenko N.V., Zubova T.V., Shatalov V.G. Familial Mediterranean fever in children. Rossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics). 2025;70(1):88-95. (In Russ.) https://doi.org/10.21508/1027-4065-2025-70-1-88-95
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